- Reaction score
- 2,028
I am not high on Serms at all. Mostly the Serm questions on Reddit go unanswered. A few non-binary folks have asserted success. Serms are mostly for people seeking a chimerical body form, meaning mixing of parts in terms of the perceptions of others. Usually these folks either seek only breast growth, or buttocks and hip growth. Some transgender individuals if not most on HRT exhibit some forms of both sexual looks. Janey might argue that seeking just hair as an XY is seeking a chimerical look but since some white XY's do have essentially perfect hair for life that can even grow to long lengths, this aspect is muted.Partly agree with you here. AA's are not needed in the sense that high enough E2 doses will do everything that AA's do (and more). However, pure AA's will halt Androgenetic Alopecia in all individuals. If you are still experiencing hair loss on a prostate cancer-dose of Apalutamide, Enzalutamide or Darolutamide your hairloss is not androgenic but due to another cause. Bicalutamide, as said, is more difficult to assess since it is non-pure and may not fully block the AR. I also think Apalutamide and Darolutamide are pretty clean since they target almost exclusively the AR and do not cause elevated liver enzymes (they are 'liver safe', unlike Bicalutamide). Of course, they carry all sides you would expect from blocking AR's, and they are extremely expensive as well (orally). If one does not care about money and is going down the HRT route, they might as well add Apa/Daro to they regimen. Enzalutamide has off-target GABA binding that causes seizures in some individuals, and can be considered inferior for this reason. It should be noted that anecdotally, AA's on their own are not known for causing regrowth but more so for maintenaince.
I am not sure why you think currently available SERMs are valueable additions to hairloss protocols except for gyno prevention (SERMs are not very healthy either and should be avoided as much as possible).
It's hard for me to be against people using HRT for whatever they want; the genie is out of the bottle but I am sort of eh about this usage of Serms as it appears to me when answering questions that such folks are sort of dabblers or wannabe's but they are still data points. I believe people should start out using the least amount of meds for HRT possible and that parenteral ingestion, i.e. non-oral, is safest. I think that the patches are the best ingestion method of high-dose estradiol overall.