Both. multiple reasons:
- It doesn't address the root cause of balding, which stems purely from the androgen receptor. Although there are some recent studies suggesting Minoxidil can bind and antagonize the AR lightly, it's not the main effect and it's not strong enough. Hence, it's a bandaid solution.
What are the real causes of baldness?
How can you say that if you don't know the pathophysiology of baldness and don't know the mechanism of action of minoxidil?
What is the mechanism of minoxidil that helps hair? Vasodilation? Increase in PGE2? Opening of potassium channels? Anti androgen? Nobody knows until today!
So tell me what is the pathophysiology of hair loss? DHT? so why DHT stimulates the follicles in the rest of the body, but in scalp in the frontal region of the head f*** everything. So how do you say you don't act on the root of the problem? What is the root of the problem?
Why do patients who undergo full transition treatment for females still fail to regrow? This thing have A lot more details than we think.
How can you make such a statement without fully understanding the pathophysiology involved?
I've seen complete recovery with minoxidil only, and with CPA only, and I've seen no results with minoxidil and with CPA too, I've seen people taking pounds of CPA and e2 and not having regrowth and then what is the mechanism of action?
Minoxidil mimics the effects of nitric oxide (NO), link
(i.e. it binds the same receptors, particularly Sgc). NO is a molecule that can best be described as pro-aging. More info on NO and why to avoid it at all costs here
. All deleterious effects on health of NO also apply to Minoxidil. Apart from this, Minoxidil has an additional array of side effects on its own:
You graduated in what? do you really know the mechanism of action of NO?
You make it sound like nitric oxide is bad!
-Minoxidil has fibriotic effects on heart tissue, as per this study.
(there are more available).
It keeps getting worse.
Minoxidil is toxic to dogs and other life forms as are thousands of other medications.
We are humans man, this DRUG IS USED FOR 50 YEARS DUDE!!!!!!!! 50 YEARS! I AM A DOCTOR AND I HAVE NEVER SEEN ANY REPORT OF IT IN THE HISTORY OF MEDICINE!
Look how you're basing your claim!
Minoxidil has deleterious effects on collagen, here
(interestingly, minoxidil is even suggested as treatment for skin conditions associated with increased
collagen. Hence, will make your skin look worse (at best).
We have thousands of types of collagen fibers
Type 1 collagen fiber
type 2 collagen fiber
collagen fiber type 3 and so on too many
Minoxidil inhibits some collagens not all, but without deleterious effects!!!!!!!!!!
am aware that such a list can possibly be made for AA's or 5ARI's as well. And it is true that none of the compounds we use are good for us. But, I believe that AA's and 5ARI's effectively counteract the balding cascade by interfering with the root cause of Androgenetic Alopecia, which is androgens. Thus, there is a strong case to be made in favor of using those, as opposed to Minoxidil. I would still use the least amount of different compounds and the lowest concentration/frequency to achieve beneficial effects.
I always say that here, everything is poison, everyone chooses their own, I have a medical degree and I came to this conclusion, I better use a vasodilator.
If you think that having AR blockade is safer than taking minoxidil then feel free, it's your choice but I could make a giant post here about REAL side effects of AR blockers from anemia to seizures, I won't keep saying that here I don't want to Be boring.
But to say that blocking RA is safer than using minoxidil a well-established drug used for decades to treat not only hypertension with thousands and thousands of medical reports on an adequate dose of course,
and say I prefer to take AR blocker because of the side effects my eyes even bleed.
And I tell you more, it may seem that this is the secret but it is not.
It seems to work right? block AR but no, I've tried souls already tried, and several other users, if you don't put a good dose of E2 forget it.
Everyone does what they want, takes what they want, and we're just expressing opinions here.
I'm a intern Doctor, in my opinion there's no comparison between a vasodilator and an AR block, it's absurd.
You say minoxidil is a dirty drug its a joke right?, so AR blockers is clean? hahahahahahaha it only has effects on the scalp. (joke)
Which hair care drug doesn't have this dirty effect tell me.
So You who are reading do what you want, but as I always say choose your medication and prepare for the side effects.
The only thing I can confirm in your post is that in HIGH DOSES! HIGH DOSES! I also presented the Elotrocardiogram dysfunction, but in a massive dosage! 40 mg, 30mg AND YOU CAN TAKE A ATENOLOL OR OTHER BETA BLOCKER! That's not completely "bad", it's an expected effect.
Spare me, minoxidil has been used for decades for hair loss, decades, and there's still this silly discussion.
I don't want to sound boring, but there are statements that come out here that only Jesus to have mercy
Do you know what is not used for hair loss? AR blockers. its totally off label, DIFFERENT FOR finasteride and dutasteride THAT ARE 5ar enzyme blockers.
AR BLOCKERS THEY ARE DESIGNED TO TREAT CANCER, THEY ARE NOT CREATED TO BE GENTLE WITH THEIR BODY PHYSIOLOGY!.
Get your head together.
Now if you say that an AR blocker can cause a much greater regrowth effect than minoxidil! Oh I agree maybe in some users. But the side effects will be quadrupled that's obvious!