Exploring The Hormonal Route. Hair=life.

[I'mme]

are they talking about mice?

(in vitro estrogen slows down human hair growth but keeps it in the growing phase longer, testosterone slows it down and puts in early telogen)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817427/

 

[bridgeburn]

Androgenetic Alopecia isn't caused by increased levels of T or DHT directly, but because of increase AR sensitivity or Androgen Receptor density (

It is caused by the local concetration in the follicles rather than the overall systematic amount.
that combined with sensitivity

"Balding scalp tissues also express higher DHT than non-balding hair-bearing scalp tissues from the same male [7] "

 

[Michael1986]

It is caused by the local concetration in the follicles rather than the overall systematic amount.
that combined with sensitivity

"Balding scalp tissues also express higher DHT than non-balding hair-bearing scalp tissues from the same male [7] "

Indeed. The male pattern baldness process is dependent upon the combined effect of androgen levels within the dermal papillae of the hair follicles and the sensitivity of these follicles to these androgens, the latter of which is determined by the number of androgen receptor sites in the dermal papillae (the more you have, the greater the sensitivity, and this is thought to increase with age).

 

[I'mme]

Indeed. The male pattern baldness process is dependent upon the combined effect of androgen levels within the dermal papillae of the hair follicles and the sensitivity of these follicles to these androgens, the latter of which is determined by the number of androgen receptor sites in the dermal papillae (the more you have, the greater the sensitivity, and this is thought to increase with age).

Exactly.. AR are dense in some people plus they are sensitive, causing them to bald frequently. @Ikarus for eg has very aggressive hair loss.

But as I said, lower T should also lower ARs - at least in theory.
Allso, no need to lower T if you can block or reduce ARs in the scalp.

 

[I'mme]

It is caused by the local concetration in the follicles rather than the overall systematic amount.
that combined with sensitivity

"Balding scalp tissues also express higher DHT than non-balding hair-bearing scalp tissues from the same male [7] "

I think local concentration increases when ARs in the scalp are higher in number as well as sensitive.

 

[Ikarus]

Look, im not feeding anything. The version he told me was different, but im not interest in this, because we are in a hair loss fórum, soo the only thing which matters for me here is informations about the disease we share, i dont give a f*** about likes and dislikes and you guys should do the same. DHTcel had a lot of information, thats why his presence is valueable for the discussion

No, he’s not needed. His information isn’t needed. He’s evidently mentally ill and has other issues to deal with before coming on a hair loss website. He PM’d me on discord that I will ‘regret’ not apologising to him, which is creepy as f***.

stop problematizing everything

He is a problem, that’s the issue. Neither do you need that much new information on how bicalutamide works, considering we have enough information on it at this point.

 

[I'mme]

Well that's what people are trying to find and do for a couple of decades already but it seems that nobody can find it because it goes on other parts were the AR's are expressed and you could take serious damage.. But yes, if they could finally and already find a f*****g one only for the scalp one, we would get rid of this sh*t once and forever, but i don't think it's any interest in it because the hair loss industry would take a huge hit with it's finding and i won't think it will happen anytime soon !

May be.

I think scientists are fully interested in finding "cure" for hair loss - it's just dermatologists and hair loss specialists who aren't.
Finding cure is tremendously difficult because it's T that needs to be blocked (reduced to a great extent) for hair loss to stop and regrowth to take place. But then T is what make a man a man.

 

[Father_of_Shiseido]

May be.

I think scientists are fully interested in finding "cure" for hair loss - it's just dermatologists and hair loss specialists who aren't.
Finding cure is tremendously difficult because it's T that needs to be blocked (reduced to a great extent) for hair loss to stop and regrowth to take place. But then T is what make a man a man.

It's not actually true. In male-pattern baldness, some of the specific proteins are missing due to androgen. If we can find that protein mbp can be cured without suppressing T. Hopefully, they have found that protein from the human mole. They are going to begin the human trial.

https://newhair.com/baldingblog/new-podcast-by-william-rassman/

 

[I'mme]

I think that if they would find a way to keep the AR's on the scalp to be numb to it's effect it would be the best for everybody, but i don't think it's that simple... Regarding T to be blocked it's not an option for the majority so it's out of discussion...

It is definitely not simple but we have some SARMS that are selective on muscles. Once person for example grew hair in Ostarine, another told that his hair improved.
Most men with male pattern baldness/Androgenetic Alopecia didn't report losing ground on LGD 4033.
These are the type of drugs that can localise the activity of ARs.
Like Raloxifene, which is anti-estrogenic in breast tissue and some other parts but estrogenic in estrogenicother parts.
Such SARMs should be created that would be androgenic/anabolic in muscle tissue but estrogenic/Anti-androgenic in scalp tissue. This should be pretty difficult though.

 

[I'mme]

Li

It's not actually true. In male-pattern baldness, some of the specific proteins are missing due to androgen. If we can find that protein mbp can be cured without suppressing T. Hopefully, they have found that protein from the human mole. They are going to begin the human trial.

Link? Details? Studies?

 

[Father_of_Shiseido]

Li

Link? Details? Studies?

https://newhair.com/baldingblog/new-podcast-by-william-rassman/

Soon they are going to publish a good journal on it.

 

[Father_of_Shiseido]

Yeah i saw that also, it's really interesting but he is doing trials only on his billionaire friends i saw a podcast with him on this subject, but indeed sounds really interesting but we will have to wait and see how it goes !

That's not true. He has many volunteers for this trial. He also said that the people are dying to be the part of this study.

 

[Father_of_Shiseido]

From what i heard on that podcast he said that he only takes his closed ones that are pressing him to get into the trials... Maybe he changed his mind, i'm just saying what i heard from his podcast

See his previous podcast. He gave very detailed information on that.

 

[Letsdoit]

He PM’d me on discord that I will ‘regret’ not apologising to him, which is creepy as f***.

He clearly suffers from mental health issues and people here are cheering him on and wants him to get set free...just go no contact with him and he will switch his attention.

 

[Itsnoahkennedy]

and the massive shed continues lol.

 

[I'mme]

and the massive shed continues lol.

That's duta shed. You can only cope by knowing that regrown hair would be better than the ones that you're shedding.

 

[Itsnoahkennedy]

That's duta shed. You can only cope by knowing that regrown hair would be better than the ones that you're shedding.

I'm looking forward to it, i have never in my life shed this hard from 5-ar inhibitors alone, but duta + HRT at the same time must really be working.

 

[Father_of_Shiseido]

That's duta shed. You can only cope by knowing that regrown hair would be better than the ones that you're shedding.

Excessive shedding is never a good signal. It indicates that your jeans are winning the battle. Each time have I shed excessively, it never returned back to the previous density.

 

[BRezende]

I got a massive shedding from finasteride in only 1 month, lost 1/5 of my hair.

 

[Yar]

I got a massive shedding from finasteride in only 1 month, lost 1/5 of my hair.

I think finasteride and dutasteride are bad for hair. It's just PR about the effectiveness of these drugs.