Discussion in 'Success Stories' started by bridgeburn, Oct 27, 2017.
How about leaving cypro and just estrodiol, dutasteride and oral min?
I don't take cpa because it is a partial agonist of the ar, I don't take estradiol because I want to stay male, I don't take oral min because I don't want to look like a bloated water buffalo. Bica + dutas + topical minoxidil is all I take and a little raloxifene to reduce/prevent gyno
Bicalutamide, sold under the brand name Casodexamong others, is an antiandrogen medication that is primarily used to treat prostate cancer. It is typically used together with a gonadotropin-releasing hormone (GnRH) analogue or surgical removal of the testicles to treat advanced prostate cancer.Bicalutamide may also be used to treat excessive hair growth in women, as a component of feminizing hormone therapy for transgender women, to treat early puberty in boys, and to prevent overly long-lasting erections in men. It is taken by mouth.
so doesnt bica affect masculanity too? not to mention the erection side it could have...how has it been for you?
again, the only feminizing side effect of bicalutamide is gynecomastia and reduction in body hair. It doesn't effect bone mineral density nor muscle mass. Its a gonaditropen and not an antigonaditropen. It also has antiprogesteronic effects and does not act as a steroidal anti androgen.
as for libido,
"Another large study reported a rate of impotence of only 9.3% with bicalutamide relative to 6.5% for standard care (the controls), a rate of decreased libido of only 3.6% with bicalutamide relative to 1.2% for standard care, and a rate of 9.2% with bicalutamide for hot flashes relative to 5.4% for standard care. One other study reported decreased libido, impotence, and hot flashes in only 3.8%, 16.9%, and 3.1% of bicalutamide-treated patients, respectively, relative to 1.3%, 7.1%, and 3.6% for placebo. It has been proposed that due to the lower relative effect of NSAAs on sexual interest and activity, with two-thirds of advanced mPC patients treated with them retaining sexual interest, these drugs may result in improved quality of life and thus be preferable for those who wish to retain sexual interest and function relative to other antiandrogen therapies in prostate cancer."
hope this helps bro
Frankly, I do not understand what the problem is. no one has yet died from such regimes. The fact is that all these drugs are of different actions. each works in its own way. I do not even exceed the recommended rate. for example, flutamide can be taken 3 times a day at 250 mg. Cyproterone maximum permitted dose is generally 400 mg. in fact, I did not add recommendations that are allowed. in the future, I am going to reduce cyproterone to 25 mg of bicalutamide to 50 mg and flutamide to 250 mg. but testosterone must be at the feminine level for feminization. I still have it.
when you really want your hair you are ready to go for anything.
you do realize that using cyproterone/spironolactone in combination with an NSAA basically renders them (bica/flut) useless right?
"All medically used SAAs are weak partial agonists of the AR rather than silent antagonists, and for this reason, possess inherent androgenicity in addition to their predominantly antiandrogenic actions. In accordance, although CPA produces feminization of and ambiguous genitalia in male fetuses when administered to pregnant animals, it has been found to produce masculinization of the genitalia of female fetuses of pregnant animals. Additionally, all SAAs, including CPA and spironolactone, have been found to stimulate and significantly accelerate the growth of androgen-sensitive tumors in the absence of androgens, whereas NSAAs like flutamide have no effect and can in fact antagonize the stimulation caused by SAAs. Accordingly, unlike NSAAs, the addition of CPA to castration has never been found in any controlled study to prolong survival in prostate cancer to a greater extent than castration alone. In fact, a meta-analysis found that the addition of CPA to castration actually reduces the long-term effectiveness of ADT and causes an increase in mortality (mainly due to cardiovascular complications induced by CPA). Also, there are two case reports of spironolactone actually accelerating progression of metastatic prostate cancer in castrated men treated with it for heart failure, and for this reason, spironolactone has been regarded as contraindicated in patients with prostate cancer. Because of their intrinsic capacity to activate the AR, SAAs are incapable of maximally depriving the body of androgen signaling, and will always maintain at least some degree of AR activation."
hope this helped
Can this bloating be reduced by eating bananas (=taking more potassium)? People who take MK667 take bananas to reduce water retention.
probably, I took mk677 for 2 months for height (I grew half an inch) and I was definitely bloated. potassium offsets sodium so you are right
Hey bridge, I am still reading up facts on net before I take the plunge. So I came up with this:
Check the section about bone changes which says "There is evidence that the risk of problems such as bone fractures is slightly higher for men having long term treatment to block testosterone"
f***, I'm like 5'8 or 5'9 only. Way above average Indian height (5'1 for males, 5'5 as per some measures), but if I could grow 2-3 inches, I would love me more.
But to increase height you've to do exactly opposite of what you'd do to save hair. Man, my life is so fucked up at this point - I know how to achieve what I want, but I can't.
Anyway, thank you buddy. If I get 80% density with big3, I'm definitely gonna try mk667.(along with some others - definitely not letrozole though; hair=life )
im 5foot8 right now, but if you take cpa for example, that lowers LH which then lowers T and E. anything that lowers T/LH in men or T/E in women will make them taller. Letrozole wouldn't make you taller because it doubles on LH secretion and T levels. The studies of height and letrozole is with female mice.
What are you saying, DHTcel? The standard treatment includes HGH, MK667, letrozole, MSM among others. Three of which increases testosterone. So can we not say that to increase height we need to increase test and reduce (or demolish) estrogen? (BTW, not gonna do it ; love my hair more)
HGH and mk677 increase Growth hormone and have no effect on testosterone levels or estrogen levels.
Gosh... So can I take mk667 without adversely affecting my hair?
Estradiol has to be used at sufficient amounts to be used without an anti-androgen, in which significant feminisation would occur.
Bicalutamide reverses the effects of puberty, rather than cause feminisation. It gives a neotenic appearance; it makes you look youthful. It reduces sebum production significantly, leading to less skin imperfections. It also leads to smoother skin!
You were talking about taking Cyproterone + spironolactone + Bica + Flutamide + Fina + Duta............ all those drugs at high dose.
You can have testosterone at feminine levels with normal dose of CPA + Estradiol. Or if you want the best AA take Lupron and add some Bicalutamide... But I think its overkill.
Nevermind. It's your body, you can destroy it if you want, but I would not recommend it.
Really ? I don't think so, at least when it's not necessary. You dont need to take 5-7 antiandrogens at high dose to achieve that goal. You will just end at the hospital.
Try something like Cypro 12.5-25mg + 6-8mg Estrofem under supervision of an endocrinologist. If it's doens't work try something stronger, maybe ... or wait (that's what I'm doing, expecting my regimen will finally be working).