- Reaction score
- 732
Proposed treatment:
Cyclodextrin bound RU58841/Dutasteride/Finasteride for localized effects
Cyclodextrins are molecules that binds to other chemicals to make a complex that is more soluble in water. It makes sense these makes the particle size bigger in the process. Cyclodextrins struggle to travel through intact skin. However cyclodextrins can penetrate down to the follicle.
The proposed theory is to use these with dutasteride, finasteride or RU58841, and make them selectively penetrate down to the follicle but not go systemic.
Futhermore we could also find derivatives that are lipophilic for even more localized action.
This article propose using cyclodextrins to do just this:
A study on mice with regular minoxidil vs minoxidil cyclodextrin showed less side effects with the latter:
https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1002/prp2.585
Cyclodextrin bound RU58841/Dutasteride/Finasteride for localized effects
Cyclodextrins are molecules that binds to other chemicals to make a complex that is more soluble in water. It makes sense these makes the particle size bigger in the process. Cyclodextrins struggle to travel through intact skin. However cyclodextrins can penetrate down to the follicle.
The proposed theory is to use these with dutasteride, finasteride or RU58841, and make them selectively penetrate down to the follicle but not go systemic.
Futhermore we could also find derivatives that are lipophilic for even more localized action.
This article propose using cyclodextrins to do just this:
Drug Targeting to the Hair Follicles: A Cyclodextrin-Based Drug Delivery
www.ncbi.nlm.nih.gov
A study on mice with regular minoxidil vs minoxidil cyclodextrin showed less side effects with the latter:
https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1002/prp2.585