Cyclodextrin complexed RU58841/Dutasteride (Localized transfolliclar delivery)

[FollicleGuardian]

Proposed treatment:

Cyclodextrin bound RU58841/Dutasteride/Finasteride for localized effects

Cyclodextrins are molecules that binds to other chemicals to make a complex that is more soluble in water. It makes sense these makes the particle size bigger in the process. Cyclodextrins struggle to travel through intact skin. However cyclodextrins can penetrate down to the follicle.

The proposed theory is to use these with dutasteride, finasteride or RU58841, and make them selectively penetrate down to the follicle but not go systemic.

Futhermore we could also find derivatives that are lipophilic for even more localized action.

This article propose using cyclodextrins to do just this:

Drug Targeting to the Hair Follicles: A Cyclodextrin-Based Drug Delivery

www.ncbi.nlm.nih.gov

A study on mice with regular minoxidil vs minoxidil cyclodextrin showed less side effects with the latter:

https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1002/prp2.585

 

[Selb]

Boosting

 

[LouisSarkozy]

Proposed treatment:

Cyclodextrin bound RU58841/Dutasteride/Finasteride for localized effects

Cyclodextrins are molecules that binds to other chemicals to make a complex that is more soluble in water. It makes sense these makes the particle size bigger in the process. Cyclodextrins struggle to travel through intact skin. However cyclodextrins can penetrate down to the follicle.

The proposed theory is to use these with dutasteride, finasteride or RU58841, and make them selectively penetrate down to the follicle but not go systemic.

Futhermore we could also find derivatives that are lipophilic for even more localized action.

This article propose using cyclodextrins to do just this:

Drug Targeting to the Hair Follicles: A Cyclodextrin-Based Drug Delivery

www.ncbi.nlm.nih.gov

A study on mice with regular minoxidil vs minoxidil cyclodextrin showed less side effects with the latter:

https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1002/prp2.585

i'm retarded and have absolutly no idea about what you're talking about but does it min we could avoid minoxidil skin sides that way? and is cyclodextrins the same as gamma-cyclodextrine? cause i used a minoxidil containing it https://www.pierre-fabre-dermatologie.ch/fr/produits/alopexy/ and had the exact same skin sides than with other brand . thanks

 

[Zon Ama]

FollicleGuardian for president!

 

[Roeysdomi]

If it would have loclaized and not going systemic.
Wouldnt it be better to go for Trans drugs ?
like cypro or estrogen?

 

[czecha]

@ChemHead tbh

 

[FollicleGuardian]

If it would have loclaized and not going systemic.
Wouldnt it be better to go for Trans drugs ?
like cypro or estrogen?

Perhaps, but we should start with less severe drugs so to say. To know if it works.

 

[FollicleGuardian]

i'm retarded and have absolutly no idea about what you're talking about but does it min we could avoid minoxidil skin sides that way? and is cyclodextrins the same as gamma-cyclodextrine? cause i used a minoxidil containing it https://www.pierre-fabre-dermatologie.ch/fr/produits/alopexy/ and had the exact same skin sides than with other brand . thanks

It won’t help skin sides Only systemic sides

 

[TurboFixer]

It won’t help skin sides Only systemic sides

I've read some conflicting stuff about skin sides - has min be actually shown to age your skin? I saw some people say it is just the alcohol vehicle that can dry out /irritate the skin

 

[Charger]

who got da plug.

 

[czecha]

I've read some conflicting stuff about skin sides - has min be actually shown to age your skin? I saw some people say it is just the alcohol vehicle that can dry out /irritate the skin

Dude it ages tf out of ur skin and no it’s not the alc
Took years for me tho until skin looked like sh*t tbh

 

[FollicleGuardian]

Dude it ages tf out of ur skin and no it’s not the alc
Took years for me tho until skin looked like sh*t tbh

Use daily made batches of Vitamin C ascorbic acid (increases the enzyme minoxidil decreases, lysyl hydroxylase iirc), Retin A (not at the same time/application), low dose estriol cream. All for skin.

 

[FollicleGuardian]

who got da plug.

You can literally get cyclo on Ebay

 

[LouisSarkozy]

I've read some conflicting stuff about skin sides - has min be actually shown to age your skin? I saw some people say it is just the alcohol vehicle that can dry out /irritate the skin

Use daily made batches of Vitamin C ascorbic acid (increases the enzyme minoxidil decreases, lysyl hydroxylase iirc), Retin A (not at the same time/application), low dose estriol cream. All for skin.

which estril cream would you recommend and how often? wouldn't it lead to facial feminization overtime? thanks again

do you have any studies showing vitamin c increase lysil hydroxylase i'm sorry to ask tried to read some but i'm too low iq to find one.

 

[Moosey]

I've read some conflicting stuff about skin sides - has min be actually shown to age your skin? I saw some people say it is just the alcohol vehicle that can dry out /irritate the skin

It doesnt actually fast forward your biological clock for your skin. But yeah for some people (like me) it can make your skin look awful. I dont have high standards for my skin but god damn did i look horrible. The eyes looked sh*t too.
Legit one of the reasons i will never touch minoxidil again

 

[FollicleGuardian]

which estril cream would you recommend and how often? wouldn't it lead to facial feminization overtime? thanks again

do you have any studies showing vitamin c increase lysil hydroxylase i'm sorry to ask tried to read some but i'm too low iq to find one.

Biolabs pro or whatever they are called have good ones.


Lysyl hydroxylase and Vit C: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2589959/

 

[Lurker85]

I mix my RU58841 in liquid minoxidil. Should I try it with this instead? I can get 100 grams for $15 off Amazon for cyclo.

 

[MrKmass]

@

Proposed treatment:

Cyclodextrin bound RU58841/Dutasteride/Finasteride for localized effects

Cyclodextrins are molecules that binds to other chemicals to make a complex that is more soluble in water. It makes sense these makes the particle size bigger in the process. Cyclodextrins struggle to travel through intact skin. However cyclodextrins can penetrate down to the follicle.

The proposed theory is to use these with dutasteride, finasteride or RU58841, and make them selectively penetrate down to the follicle but not go systemic.

Futhermore we could also find derivatives that are lipophilic for even more localized action.

This article propose using cyclodextrins to do just this:

Drug Targeting to the Hair Follicles: A Cyclodextrin-Based Drug Delivery

www.ncbi.nlm.nih.gov

A study on mice with regular minoxidil vs minoxidil cyclodextrin showed less side effects with the latter:

https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1002/prp2.585

I'll make a finasteride solution to try and keep you posted.

What vehicle and how much Cyclodextrin for a 2oz bottle?

 

[bags]

going to call my guy and ask him to compound my dutasteride with

hydroxypropyl-β-cyclodextrin​

as that seems to be the compound of choice in all the stuides... but seeing he is a chemist ill ask his final opinon. one study did show they used Alpha which is why I was confused but almost all the other studies used Beta.....

 

[constrictedvoid]

going to call my guy and ask him to compound my dutasteride with

hydroxypropyl-β-cyclodextrin​

as that seems to be the compound of choice in all the stuides... but seeing he is a chemist ill ask his final opinon. one study did show they used Alpha which is why I was confused but almost all the other studies used Beta.....

Have you heard back?