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Relevant article from 2020
The mechanism whereby prolactin directly regulates hair growth is connected with its inhibitory influence on hair shaft elongation and the premature induction of the catagen phase (causes miniaturization). Moreover, luteotropin (Prolactin) also plays a significant role in the proliferation and apoptosis of keratinocytes in HFs by decreasing the number of Ki-67-positive cells and increasing the quantity of TUNEL + cells [18]. Prolactin is recognized as an androgen metabolism modulator. The luteotropic hormone seems to increase the level of free testosterone and dehydroepiandrosterone sulfate, decreasing at the same time the level of serum testosterone-estradiol-binding globulin [24,25]. PRL also appears to inhibit the activity of 5-alpha
this is interesting beacause it mentions a prolactin receptor on the outer root sheath region of the hair follicle. There can be a lot of pharmaceutical approaches for blocking its activity. But this is hard because the external root sheath is inside a glossy membrane. It will be hard for the molecule to interact with that receptor. It also says prolactin inhibits 5ar activity.I know in men and women prolactin causes increased expression of estrogen receptors this can be a good reason why miniaturization is much slower in women:
“The ability of the rat corpus luteum to respond to estrogen requires prolactin (PRL), which can stimulate the expression of the estrogen receptor (ER).”
The mechanism whereby prolactin directly regulates hair growth is connected with its inhibitory influence on hair shaft elongation and the premature induction of the catagen phase (causes miniaturization). Moreover, luteotropin (Prolactin) also plays a significant role in the proliferation and apoptosis of keratinocytes in HFs by decreasing the number of Ki-67-positive cells and increasing the quantity of TUNEL + cells [18]. Prolactin is recognized as an androgen metabolism modulator. The luteotropic hormone seems to increase the level of free testosterone and dehydroepiandrosterone sulfate, decreasing at the same time the level of serum testosterone-estradiol-binding globulin [24,25]. PRL also appears to inhibit the activity of 5-alpha
this is interesting beacause it mentions a prolactin receptor on the outer root sheath region of the hair follicle. There can be a lot of pharmaceutical approaches for blocking its activity. But this is hard because the external root sheath is inside a glossy membrane. It will be hard for the molecule to interact with that receptor. It also says prolactin inhibits 5ar activity.I know in men and women prolactin causes increased expression of estrogen receptors this can be a good reason why miniaturization is much slower in women:
“The ability of the rat corpus luteum to respond to estrogen requires prolactin (PRL), which can stimulate the expression of the estrogen receptor (ER).”
Prolactin regulation of estrogen receptor expression - PubMed
The ability of the rat corpus luteum to respond to estrogen requires prolactin (PRL), which can stimulate the expression of the estrogen receptor (ER). This review will focus on the signaling mechanisms by which this occurs. Transcription of the genes encoding both ERalpha (Esr1) and ERbeta...
pubmed.ncbi.nlm.nih.gov
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