This image shows the expression of several hair growth genes in mesenchymal cells of RUNX2- mice. GLI1, FGFR2, TCF7, and Wnt10b are virtually eliminated when RUNX2 is downregulated.
Here is a review on prolactin's regulation of stem/progenitor cells, with a little bit about prolactin in the hair follicle.
Runx2 regulates cranial suture closure by inducing hedgehog, Fgf, Wnt and Pthlh signaling pathway gene expressions in suture mesenchymal cells - PubMed
Cleidocranial dysplasia (CCD, #119600), which is characterized by hypoplastic clavicles, open fontanelles, supernumerary teeth and a short stature, is caused by heterozygous mutations in RUNX2. However, it currently remains unclear why suture closure is severely impaired in CCD patients. The...
pubmed.ncbi.nlm.nih.gov
Here is a review on prolactin's regulation of stem/progenitor cells, with a little bit about prolactin in the hair follicle.
Minireview: Prolactin Regulation of Adult Stem Cells
Adult stem/progenitor cells are found in many tissues, where their primary role is to maintain homeostasis. Recent studies have evaluated the regulation of adult stem/progenitor cells by prolactin in various target tissues or cell types, including the ...
www.ncbi.nlm.nih.gov