Bayer Prolactin Receptor Antibody For Male And Female Pattern Hair Loss

[5minutesbeforemiracle]

Oh nice so a couple of years will be needed for the actual knowledge

No, you're thinking too long. Few years is needed for treatment, hopefully

 

[Letitgrow]

No, you're thinking too long. Few years is needed for treatment, hopefully

Yeah, we can only hope.

 

[Chads don't bald]

Our observations further suggest that PRL alone and in synergy with IFN-gamma, released through induction of IL-12, may generate tumoricidal macrophages and thus regulate the antitumor immune response of tumor hosts.

That's got me worried a bit. If PRL generates macrophages which are needed to fight tumors, are we putting ourselves at risk with no antitumor immune response? On the other hand, they say PRL, not PRLR, so IDK if it's that you just need PRL for this function, rather than PRL activation of the PRLR, in which case we'd be fine, since we're just blocking the receptor, rather than lowering PRL.

Well doesn't SMI lower PRL? While HMI blocks PRLR?

So SMI could possibly be tumorigenic?

 

[Gegen]

Well doesn't SMI lower PRL? While HMI blocks PRLR?

So SMI could possibly be tumorigenic?

SMI is a competitive inhibitor of PRLRs, HMI is an incompetitive one.
It means that HMI will be more potent than SMI as HMI can inhibit PRLRs even when prolactin is sticked on the receptor. SMI can't and has to be in competition with Prolactin to fix to the receptor.

 

[Dimitri001]

https://europepmc.org/article/pmc/1606541

Not sure if the above has been shared already, but seems to be further research showing lower PRL can be good for hair when elevated

Our data suggest that PRL acts as an autocrine hair growth modulator with catagen-promoting functions and that the hair growth-inhibitory effects of PRL demonstrated here may underlie the as yet ill-understood hair loss in patients with hyper-prolactinemia

In 2006 they found this. Makes you wonder about all the treatments you found research on that then was never followed through on.

The bit about hair loss in hyper-prolactinemia is interesting. Does everyone with hyper-prolactinemia have hair loss? I imagine not otherwise the causal link would have been spotted long ago, but it makes you wonder why not.

Presumably all people have PRL in their HFs, why do some bald from it others not? Is it that you have to have PRL+excess DHT or PRL+androgen sensitivity? Obviously androgens are definitely involved, so it has to be that both PRL and the androgen angle are necessary for hairloss.

By why do some with hyper-PRL bald and others not? (if that is indeed so) Presumably rate of balding is higher among hyper-PRL, since they mention it, in other words it's not just that it's the people who would have balded anyway, even in absence of hyper-PRL.

 

[Zon Ama]

Here you Can Read about the partnership of Hope Medicine and PAREXEL in developping HMI-115 with clinical trials planned in Europe:

新闻速递 | 这条过江通道将建双层跨江大桥

锦文路过江通道将建双层跨江大桥南京审计大学毕业生升学占比27...

c.m.163.com

I Hope they will Start the clinical study in Berlin as soon as possible

Contact me when they start in Berlin bro, i will also register

 

[Chads don't bald]

SMI is a competitive inhibitor of PRLRs, HMI is an incompetitive one.
It means that HMI will be more potent than SMI as HMI can inhibit PRLRs even when prolactin is sticked on the receptor. SMI can't and has to be in competition with Prolactin to fix to the receptor.

Good to know, so the PRL will still be there and functional in the body to generate macrophages etc.

 

[Dimitri001]

Sorry if this has been covered, but why were the Discord guys unable to procure HMI? I seem to remember hearing something about it being difficult to manufacture. Or is it because of the patent?

 

[Throwaway94]

Sorry if this has been covered, but why were the Discord guys unable to procure HMI? I seem to remember hearing something about it being difficult to manufacture. Or is it because of the patent?

Outrageously expensive, custom monoclonal antibody manufacture in reasonably large scale was quoted in the millions

 

[RolfLeeBuckler]

There is a brandnew newspaper (September 2021!) with Henri Nico Doods (CEO of Hope Medicine) on the cover:
《进出口经理人》2021年第9期 卷首语 (tradetree.cn)

Is anybody able to read the article?

 

[Shush]

There is a brandnew newspaper (September 2021!) with Henri Nico Doods (CEO of Hope Medicine) on the cover:
《进出口经理人》2021年第9期 卷首语 (tradetree.cn)

View attachment 169630

Is anybody able to read the article?

It says cure in 5 years : Finoxidil is coming.
Jokes apart, should we be hyped?

 

[scientist_0005]

This topic was covered a while back briefly as a piece of hope surrounding new entrants to the market however thought i would highlight some findings from the patent itself that gave me some fresh hope.

The drug in question is Bayer's PRL receptor anti-body drug that specifically targets the PRL receptor.

"PRLR-mediated signaling plays a role in a variety of processes such as mammary gland development, lactation, reproduction, mammary and prostate tumor growth, autoimmune diseases, general growth and metabolism, and immunomodulation"

It was speculated in the last post on this topic that the drug wouldn't be effective because these traits were assumed to be linked to prolactin itself. Dopamine agonists such as Cabergoline that suppress prolactin have no beneficial effect for Androgenetic Alopecia hinting this would be equally ineffective.

However, it appears the actual supression of serum prolactin itself is not a metric for effectiveness ...

"The pituitary PRL secretion can be inhibited by use of bromocriptine and other dopamine receptor 2 agonists. These agents, however, do not suppress extrapituitary PRL synthesis that can compensate successfully for the inhibition of pituitary PRL synthesis leading to almost unimpaired PRLR-mediated signalling"

As for results when trialed on stumptail macaques it was found that over a 6 month period results of hair growth did not peak during the 6 month time period. A drastic increase of the terminal hair count in bald areas (109 % increase) was demonstrated as well as an increase in transition areas.

Not exactly new news however in light of RCH-01 being a let down this might be of some comfort for the future.

Patent : https://patents.google.com/patent/WO2019011719A1/en

RU58841 - Research and Study Results for Hair Growth | Hairguard

In this article you’re going to learn about RU58841. You’ll learn what it is, how effective it is at reversing hair loss, how to use it, how to make it, and associated side effects. You’ll see (from scientific studies) just how effectively this chemical can re-grow your hair. If you have tried...

www.hairguard.com

macaques responded to RU with 104% increase and to finasteride with 88% increase, both far superior to how humans respond to those drugs. if they monkeys had regrowth, that is nice and well and humans might get some but i advice people to tame their expectations and macaques tend to be better responders..

 

[scientist_0005]

RU58841 - Research and Study Results for Hair Growth | Hairguard

In this article you’re going to learn about RU58841. You’ll learn what it is, how effective it is at reversing hair loss, how to use it, how to make it, and associated side effects. You’ll see (from scientific studies) just how effectively this chemical can re-grow your hair. If you have tried...

www.hairguard.com

macaques responded to RU with 104% increase and to finasteride with 88% increase, both far superior to how humans respond to those drugs. if they monkeys had regrowth, that is nice and well and humans might get some but i advice people to tame their expectations and macaques tend to be better responders..

"After 5 months, in addition to an average of two- to three-fold increase in the number of scalp follicles, the macaques also had more follicles in the anagen"
2-3 fold increase. this makes HMI appear not that great it seems macaques are just extremely good responders or its brcsuse they have different types of hair. however if RU worked better for them than HMI, this is not a very promising endevor especially bc of the price and if these results translate like RU results it sill be a weak finasteride at best

 

[pegasus2]

"After 5 months, in addition to an average of two- to three-fold increase in the number of scalp follicles, the macaques also had more follicles in the anagen"
2-3 fold increase. this makes HMI appear not that great it seems macaques are just extremely good responders or its brcsuse they have different types of hair. however if RU worked better for them than HMI, this is not a very promising endevor especially bc of the price and if these results translate like RU results it sill be a weak finasteride at best

HMI worked a lot better than RU in macaques. I've already explained that in this thread so I won't repeat myself

 

[scientist_0005]

HMI worked a lot better than RU in macaques. I've already explained that in this thread so I won't repeat myself

what page?

 

[pegasus2]

what page?

Hell if I know. I don't have time to go through every page and find it. Try the search function

 

[scientist_0005]

“O MNX, O+T dutasteride, 40mg estriol, erlotinib, microneedling monthly, RU58841, SAG, WAY-316606, PGE2, Eplerenone, Epitalon, Rapamycin, CHIR99021, bisindolylmaleimide, SW033291, Dinoprost, TB-500, BPC-157, Thymalin, Many supplements”

HAHAHAHAHAHAHAAA man you are a desperate old balding f*** !

just imagine having such a miserable life and being penetrated every single day by your deepest insecurities that you make an account on a hair loss forum only to insult people, then you make your profile private because people should not see what a sad incel you are. carry on

 

[pegasus2]

“O MNX, O+T dutasteride, 40mg estriol, erlotinib, microneedling monthly, RU58841, SAG, WAY-316606, PGE2, Eplerenone, Epitalon, Rapamycin, CHIR99021, bisindolylmaleimide, SW033291, Dinoprost, TB-500, BPC-157, Thymalin, Many supplements”

HAHAHAHAHAHAHAAA man you are a desperate old balding f*** !

Hey friend

 

[Dimitri001]

“O MNX, O+T dutasteride, 40mg estriol, erlotinib, microneedling monthly, RU58841, SAG, WAY-316606, PGE2, Eplerenone, Epitalon, Rapamycin, CHIR99021, bisindolylmaleimide, SW033291, Dinoprost, TB-500, BPC-157, Thymalin, Many supplements”

HAHAHAHAHAHAHAAA man you are a desperate old balding f*** !

Just report all these kind of trolling posts of which we've had a deluge recently. Hopefully that will lead to a ban.

 

[Ollie]

RU58841 - Research and Study Results for Hair Growth | Hairguard

In this article you’re going to learn about RU58841. You’ll learn what it is, how effective it is at reversing hair loss, how to use it, how to make it, and associated side effects. You’ll see (from scientific studies) just how effectively this chemical can re-grow your hair. If you have tried...

www.hairguard.com

macaques responded to RU with 104% increase and to finasteride with 88% increase, both far superior to how humans respond to those drugs. if they monkeys had regrowth, that is nice and well and humans might get some but i advice people to tame their expectations and macaques tend to be better responders..

% changes are pointless measurements here. If you have 1 hair then get a 105% increase you have just over 2 hairs. There are finasteride responders who double their hair whilst almost already fullheads dont.
The true thing to note in the HMI trials is that the monkeys received an increase of hair of between 50-220 hairs per cm^2 .