I just found a Chinese wechat blogger wrote to Professor Xiao Ruiping through email and got a courtesy reply to his questions. Here's the link:
Let me correct that part “and are currently being tested in the applicant's[volunteer's?] body”. The original Chinese means "the application for human experiment is underway".
Yes, but don't expect much. Zinc is beneficial, but many people have used it with little in the way of cosmetic results.
There is 0 profit in a hair loss treatment compared to larger ticket causes, despite what bald people will tell you.
That's amazing.
Yes that's what it means.
I will note a couple things about this before people freak out. As highlighted above, estrogen receptor alpha is the one that promotes prolactin production. Estrogen receptor alpha is also shown to initiate the catagen phase. Estrogen grows hair because the predominant estrogen receptor in human hair follicles is beta. ERb silences the actions of ERa, so estrogen does not promote prolactin production in human scalp hair follicles.Although it's been documented that Zinc won't have any cosmetic results, if we take into account that our GH levels already naturally decrease as we age and that this downregulation may be locally exponentiated during hairloss, it could be a reasonable approach to implement in order to control extra pituitary prolactin (ePRL the one produced locally by hair and skin) activity.
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Leaving some of the studies and information I read today in case someone considers it useful.
"Regulation of extra pituitary prolactin
The 2 key hormones, estrogen and TRH, that control pPRL secretion also regulate ePRL and PRL-R expression in human scalp skin and hair follicles in vitro. Estrogen increases the expression of ePRL and PRL-R proteins in the epidermis, eccrine sweat glands and hair follicle ORS, corresponding to increased ePRL and PRL-R mRNA expression in ORS keratinocytes (87). The effect of TRH is more complex. In cultured human hair follicles, TRH increases ePRL mRNA and protein expression similar to estrogen. However, PRL-R expression at the protein level is decreased whereas PRL-R mRNA at the gene level is increased (87)... Recently, both PRL and its receptor have been located in inner root sheath and outer root sheath (ORS) keratinocytes of anagen and catagen hair follicles of mice".
Minireview: Extrapituitary Prolactin: An Update on the Distribution, Regulation, and Functions
Prolactin (PRL) is an important hormone with many diverse functions. Although it is predominantly produced by lactrotrophs of the pituitary there are a number of other organs, cells, and tissues in which PRL is expressed and secreted. The impact of this ...www.ncbi.nlm.nih.gov
"Oestrogen treatment significantly upregulated PRL and PRLR immunoreactivity in selected skin and hair follicle compartments, at the gene and protein level (P < 0.05). TRH significantly increased PRL immunoreactivity and transcription in hair follicles (P < 0.05); however, while it also increased PRLR transcription in hair follicles, it downregulated PRLR immunoreactivity in the hair follicle ORS"
Thyrotropin-releasing hormone and oestrogen differentially regulate prolactin and prolactin receptor expression in female human skin and hair follicles in vitro - PubMed
Our pilot study shows that two key endocrine controls of pituitary PRL secretion, oestrogen and TRH, also regulate PRL and PRLR expression in human skin. This provides novel insights into the regulation of extrapituitary PRL and PRLR expression, and invites exploration of oestrogen and TRH as...pubmed.ncbi.nlm.nih.gov
"Estradiol activates the hPrl promoter in extra pituitary sites such as skin and human hair follicles. This study, we show that E2 acts through ERα to activate the hPrl promoter through a degenerate estrogen response element (ERE) sequence found at −1189 bp relative to the transcription start site."
Human Prolactin Gene Promoter Regulation by Estrogen: Convergence with Tumor Necrosis Factor-α Signaling
Estrogens have been implicated in the regulation of prolactin gene expression in man, although previous studies have not defined the molecular mechanism whereby estradiol activates the human prolactin gene promoter (hPrl). We found that estradiol induced ...
Impressive. Mr. Dog.Although it's been documented that Zinc won't have any cosmetic results, if we take into account that our GH levels already naturally decrease as we age and that this downregulation may be locally exponentiated during hairloss, it could be a reasonable approach to implement in order to control extra pituitary prolactin (ePRL the one produced locally by hair and skin) activity.
------ - - - -
Leaving some of the studies and information I read today in case someone considers it useful.
"Regulation of extra pituitary prolactin
The 2 key hormones, estrogen and TRH, that control pPRL secretion also regulate ePRL and PRL-R expression in human scalp skin and hair follicles in vitro. Estrogen increases the expression of ePRL and PRL-R proteins in the epidermis, eccrine sweat glands and hair follicle ORS, corresponding to increased ePRL and PRL-R mRNA expression in ORS keratinocytes (87). The effect of TRH is more complex. In cultured human hair follicles, TRH increases ePRL mRNA and protein expression similar to estrogen. However, PRL-R expression at the protein level is decreased whereas PRL-R mRNA at the gene level is increased (87)... Recently, both PRL and its receptor have been located in inner root sheath and outer root sheath (ORS) keratinocytes of anagen and catagen hair follicles of mice".
Minireview: Extrapituitary Prolactin: An Update on the Distribution, Regulation, and Functions
Prolactin (PRL) is an important hormone with many diverse functions. Although it is predominantly produced by lactrotrophs of the pituitary there are a number of other organs, cells, and tissues in which PRL is expressed and secreted. The impact of this ...
"Oestrogen treatment significantly upregulated PRL and PRLR immunoreactivity in selected skin and hair follicle compartments, at the gene and protein level (P < 0.05). TRH significantly increased PRL immunoreactivity and transcription in hair follicles (P < 0.05); however, while it also increased PRLR transcription in hair follicles, it downregulated PRLR immunoreactivity in the hair follicle ORS"
Thyrotropin-releasing hormone and oestrogen differentially regulate prolactin and prolactin receptor expression in female human skin and hair follicles in vitro - PubMed
Our pilot study shows that two key endocrine controls of pituitary PRL secretion, oestrogen and TRH, also regulate PRL and PRLR expression in human skin. This provides novel insights into the regulation of extrapituitary PRL and PRLR expression, and invites exploration of oestrogen and TRH as...
"Estradiol activates the hPrl promoter in extra pituitary sites such as skin and human hair follicles. This study, we show that E2 acts through ERα to activate the hPrl promoter through a degenerate estrogen response element (ERE) sequence found at −1189 bp relative to the transcription start site."
Human Prolactin Gene Promoter Regulation by Estrogen: Convergence with Tumor Necrosis Factor-α Signaling
Estrogens have been implicated in the regulation of prolactin gene expression in man, although previous studies have not defined the molecular mechanism whereby estradiol activates the human prolactin gene promoter (hPrl). We found that estradiol induced ...
maybe i'm totally out of context and no talking about the right type of oestrogen but if ERa are bad why does product like pantostin conaining 17a oestradiol are recommended for hairloss? https://pubmed.ncbi.nlm.nih.gov/7398983/ thanks
It binds to both main estrogen receptors, alpha and beta same as 17b estradiol. The a and b in estradiol have nothing to do with the receptor it binds to.
This is why I have concerns about topical SMI, I worry that PRLR must be blocked systemically to prevent macrophages from outside invading the HF."In vivo inhibition of macrophage function was sufficient to induce HFSC proliferation and hair cycle induction. Together these results clarify how JAK-STAT signaling actively inhibits hair growth"
A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth - PubMed
Hair growth can be induced from resting mouse hair follicles by topical application of JAK inhibitors, suggesting that JAK-STAT signaling is required for maintaining hair follicle stem cells (HFSCs) in a quiescent state. Here, we show that Oncostatin M (OSM), an IL-6 family cytokine, negatively...
"PRL synergized with the TH1 cytokine IFN-gamma, a known activator of macrophages..."
Prolactin regulates antitumor immune response through induction of tumoricidal macrophages and release of IL-12 - PubMed
The involvement of PRL in regulating monocyte/macrophage functions is suggested by the presence of PRL-Rs in these cells. Here, we show that PRL, though it failed to activate mouse peritoneal resident macrophages (RMs), acted as a second signal and activated mouse peritoneal inflammatory...
IFN-γ Primes Macrophage Activation by Increasing Phosphatase and Tensin Homolog via Downregulation of miR-3473b
The classical activation of macrophages, one of major innate effector cells, requires IFN-γ pretreatment (priming) and subsequent TLR stimuli (triggering). The priming effect of IFN-γ can promote macrophages to secrete higher level of proinflammatory cytokines but lower level of the...www.jimmunol.org
"macrophages have been reported to produce PRL and express high levels of prolactin receptor (PRLR)"
Prolactin-induced production of cytokines in macrophages in vitro involves JAK/STAT and JNK MAPK pathways
Abstract. Macrophages play a crucial role in host immunosurveillance against pathogens and malignancies. The enhanced productions of pro-inflammatory cytokinesacademic.oup.com
"PRL synergized with the TH1 cytokine IFN-gamma, a known activator of macrophages"
Prolactin regulates antitumor immune response through induction of tumoricidal macrophages and release of IL-12 - PubMed
The involvement of PRL in regulating monocyte/macrophage functions is suggested by the presence of PRL-Rs in these cells. Here, we show that PRL, though it failed to activate mouse peritoneal resident macrophages (RMs), acted as a second signal and activated mouse peritoneal inflammatory...
I don't think it's a problem, just a small potential that it could be. If it was then adding cabergoline wouldn't help. Macrophages produce their own prolactin and have their own PRLRs
"In vivo inhibition of macrophage function was sufficient to induce HFSC proliferation and hair cycle induction. Together these results clarify how JAK-STAT signaling actively inhibits hair growth"
A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth - PubMed
Hair growth can be induced from resting mouse hair follicles by topical application of JAK inhibitors, suggesting that JAK-STAT signaling is required for maintaining hair follicle stem cells (HFSCs) in a quiescent state. Here, we show that Oncostatin M (OSM), an IL-6 family cytokine, negatively...
"PRL synergized with the TH1 cytokine IFN-gamma, a known activator of macrophages..."
Prolactin regulates antitumor immune response through induction of tumoricidal macrophages and release of IL-12 - PubMed
The involvement of PRL in regulating monocyte/macrophage functions is suggested by the presence of PRL-Rs in these cells. Here, we show that PRL, though it failed to activate mouse peritoneal resident macrophages (RMs), acted as a second signal and activated mouse peritoneal inflammatory...IFN-γ Primes Macrophage Activation by Increasing Phosphatase and Tensin Homolog via Downregulation of miR-3473b
The classical activation of macrophages, one of major innate effector cells, requires IFN-γ pretreatment (priming) and subsequent TLR stimuli (triggering). The priming effect of IFN-γ can promote macrophages to secrete higher level of proinflammatory cytokines but lower level of the...
"macrophages have been reported to produce PRL and express high levels of prolactin receptor (PRLR)"
Prolactin-induced production of cytokines in macrophages in vitro involves JAK/STAT and JNK MAPK pathways
Abstract. Macrophages play a crucial role in host immunosurveillance against pathogens and malignancies. The enhanced productions of pro-inflammatory cytokines
"PRL synergized with the TH1 cytokine IFN-gamma, a known activator of macrophages"
Prolactin regulates antitumor immune response through induction of tumoricidal macrophages and release of IL-12 - PubMed
The involvement of PRL in regulating monocyte/macrophage functions is suggested by the presence of PRL-Rs in these cells. Here, we show that PRL, though it failed to activate mouse peritoneal resident macrophages (RMs), acted as a second signal and activated mouse peritoneal inflammatory...
End of February/March.
Oh nice so a couple of years will be needed for the actual knowledge
