Follica and ari were the only smart teams, and they've struggled badly. No legitimate Pharma company has invested here apart from Kythera...I'm sure That Guy knows better though.
KO1 did you already migrate to Canada? Just remember that you are under command of Russia! Keep reading dat CNN. Ok, ok I'll stop teasing
. On-topic now.
I chuckled because of your message. So Follica and Aderans were the only smart team right? How do you even know who is "smarter"?
Besides just because someone is a bit "smarter" than the other doesn't really mean anything. Why would that mean anything?
See first of all it's about the method. Currently it is highly unlikely that a drug would be able to resurrect native hair follicles. The best route to take seems to be simply creating new hair follicles from scratch, since observations actually do supports this due to the flexibility and regenerative potential of the hair follicle.
Secondly you need to trust the person. You call male pattern baldness research a "clownshow". But the funny thing is that Ken Washenik and Cotsarelis are pretty much an example of a clownshow. They have been highly erroneous on many occasions (at least to the media). These are (leading) men who are or were behind Follica/ARI.
After all we need to rely on others, and to rely on someone trust is a huge factor. One would be somewhat of a fool to trust on someone who hasn't only been erroneous but simply talks nonsense, likely because of self-benefit.
Evidence is always crucial, but with someone like Washenik/Cotsarelis, I simply don't even look anymore what they have to say.
About Tsuji.
Yes they still have some problems with these cells. Perhaps it is a huge problem and it won't bring any fruits. Nonetheless, the team behind Tsuji does display confidence and they plan towards putting this stuff into
human clinical trials pretty quickly.
And with the team behind Tsuji, I do have faith and so should anyone imo. We can't do much more anyway. So I agree with
@That Guy. In fact Tsuji was literally spot on before the announcement that they (Riken) had huge plans on merging with two companies to try and bring their method to the market. And he followed up on his words. That's a rare thing in this field. It's pure finesse.
Everybody should also not forget that back in 2013 Christiano et al. managed to induce a hair shaft with cultured DP cells with partial restored signature expression, which was only 22%;
The observation of hair follicles within grafts, as described above, suggests that the 22% restoration of papilla signature is suf- ficient for follicle neogenesis.
Off course the hair shaft was shitty, not cosmetically viable and it was on fetal foreskin. Not even proper HF structure. But a hair shaft did grow! This was only with 22% signature expression.
Now you have Tsuji swooping in with, who has come way further with the DP cell culturing problem and is using also epithelial stem cells.
Also remember guys, they plan to engage in human clinical trials. My guess is that even with non-perfect cells they will simply engage in those trials. At least their words seem to indicate this.
See it's possible that even in that scenario beautiful hair follicles will grow. For instance these cells might restore some of their signature expression in vivo.
Yes guys, Tsuji your real hope here to crush Androgenetic Alopecia once and for all.
Like our very knowledgeable forum member
@InBeforeTheCure said, this will finally be the first contender for the beast that Androgenetic Alopecia is, and don't underestimate RIKEN, Kyocera and Organ Technologies, they might still be the underdog, but at least they are a true contender.