Do you have 2k$ And Doctor licence to get it?We need to take actions on our own!!
Do you have 2k$ And Doctor licence to get it?We need to take actions on our own!!
We dont.We need to take actions on our own!!
If that sh*t is safe for injecting in the eye, for me is safe enough. If you expect some doctor to just test this for the sake of humankind, forget it. If you have enough time for waiting 5 years for some researchers to make a career out of it, fine by me.We dont.
The maximum we can do is to not let the hype on this drug fade, keep eyes on the news and try to spread the information until we know for sure if this drug works on humans.
If the hype increases, we have a great chance to see doctors using it off-label, or another countries like China or Russia starting to using it before anyone else and attesting if it works or not.
This study about mechanical stress and EN1 inhibition was a enormous discovery on itself.
Verteporfin inhibiting scars on rats wasnt an accident. They knew that this drug inhibited activation of Engrailed-1 (En1) in fibroblasts. They just discovered that EN1 inhibition disables scar formation on mice. They just followed the footprints and connected the dots.
If humans respond to the same stimulus of inhibition then we have something ahead, because, as far as i remember, induced scarless healing was never docummented in rats before.
Just spread this study and we are doing alot
No but I have 2K for buying it and another 5K to pay someone who has a license. Would this be enough?Do you have 2k$ And Doctor licence to get it?
If i was rich and had the possibility to put my hands on a doctor to test it on me, i would be a guinea pig in a heartbeat.If that sh*t is safe for injecting in the eye, for me is safe enough. If you expect some doctor to just test this for the sake of humankind, forget it. If you have enough time for waiting 5 years for some researchers to make a career out of it, fine by me.
I'm not sure if you already noticed, but this whole thing just lost mometum, as it isn't the main topic anywhere, although it had good acceptance and everyone talked about it, in a few weeks it's entering the oblivion zone for another 5 years.
What can we do? I don't know, but praying for the best won't help us at all.
AICAR | Inhibitor | ≥98.0% |
---|---|---|
AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy, YAP and mitophagy inhibitor. |
The scar will be in a area that has follicles to check if is possible to regenerate it or I'm understanding this purpose wrong?wound regeneration
Don't you ever forget that curis once cured hairloss. Also, look at the developments of oxy133 for other conditions.Taking a look lately about EN1 and YAP inhibition im about to order or test few drugs capable of doing it on myself for test
CONCLUSIONS: Together, these data support that verteporfin promotes wound regeneration specifically through its effects on fibroblast YAP signaling. Furthermore, they suggest that En-1 is a mechanoresponsive master regulator of fibroblast activation; accordingly, ablation of En-1 signaling, either indirectly (YAP inhibition) or directly (DT ablation), is sufficient to trigger true wound regeneration. Our findings have translational implications as they suggest that mammalian regenerative potential might be regained in postnatal life if the dominant, mechanically-driven propensity for fibrosis can be averted.
Inhibition of EN1 through YAP inhibition results in scarless wound healing
I came to this list of drugs that can inhibit YAP signaling:
YAP (Inhibitors Agonists Modulators Antagonists) | MedChemExpress
YAP inhibitors with high purity are used in various assays for stem cell and other research areas, cited by top publications, some have entered clinical trials.www.medchemexpress.com
In the middle of those drugs that can inhibit YAP, AICAR is a relatively cheap one compared to Verteporfin, and even used orally asa supplement.
AICAR Inhibitor ≥98.0% AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy, YAP and mitophagy inhibitor.
Wound 1: Inducing a wound that would obviously turn into a scar and inject YAP inhibitor on its borders
Wound 2: Inducing a wound that would obviously turn into a scar and use a YAP inhibitor in a hydrogel with occlusion of the wound
Pre existent scar treatment 1: Reopen an existent scar, excise it and use a YAP inhibitor like Wound 1 or Wound 2 method
Pre existent scar treatment 2: Needling/wounding and applying hydrogel with occlusion of the scarred wound area
The pictures are worth 1000 words.
"Here, we show that blocking mechanical signaling via FAK inhibition promotes regenerative healing, defined by formation of healed skin with (1) restored biomechanical properties, (2) hair follicle regrowth, and (3) normal collagen fiber architecture"
is fak1 inhibtion related to yap1 inhibtion and verteporfin
yeah but i'm too retarded to understand a word but seems like the pigs regrew some hairs isn't it something huge?The pictures are worth 1000 words.
Don't be to down on yourself. You did well.yeah but i'm too retarded to understand a word but seems like the pigs regrew some hairs isn't it something huge?
original articelDisrupting biological sensors of force promotes tissue regeneration in large organisms - Nature Communications
Humans and other large mammals heal wounds by forming fibrotic scar tissue with diminished function. Here, the authors show that disrupting mechanotransduction through the focal adhesion kinase pathway in large animals accelerates healing, prevents fibrosis, and enhances skin regeneration.www.nature.com
published on septmeber the 6th of 2021 that's pretty new
"Wound tissue treated with FAKI exhibited dramatic regrowth of hair follicles and subcutaneous glands (sweat and sebaceous)"yeah but i'm too retarded to understand a word but seems like the pigs regrew some hairs isn't it something huge?
Not sure if that would be ideal. I'd rather just get dht resistant donor hair transplanted in the areas with unlimited donor.so if these results also translate to humans you could create abrasions on the bald areas, inject the drug and the hair should also be re-grown, right?
Then how it can be doneThis doesn't have to be injected