Update On Prostaglandin Protocol. Officially An Alternative To Finasteride And Minoxidil. | HairLossTalk Forums

Update On Prostaglandin Protocol. Officially An Alternative To Finasteride And Minoxidil.

Discussion in 'New Research, Studies, and Technologies' started by westonci, May 5, 2018.

  1. westonci

    westonci Experienced Member

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    Started receding around my temples around age 15-16. The male pattern baldness gene is extremely aggressive in my family and i even have sisters and mothers who have hair loss. All the men are norwood 6 by age 32 in my family.

    Below is my highschool graduation pic (year 2006). Its hard to see but I had recession in my temples that I would cover my growing my hair long.

    https://i.imgur.com/HU5cx4M.jpg

    HU5cx4M.jpg

    Before (April 2016)

    Crown
    Vertex
    Right Temple

    Hairline

    After (May 2018)

    Crown
    Vertex
    Right Temple

    After (July 2018)

    Crown


    -----------------------------------------------------------------------------------------------------

    Pros

    • No sexual or anti-androgenic sides like finasteride i.e erection/libido issues, thinning the beard (allegedly), body comp changes
    • no skin sides like minoxidil i.e bloating/water retention, dark circles, wrinkles (allegedly)
    • Setipiprant @ 2g/day massively reduces acne. Havent had a pimple in forever
    • You can get it right now through private sources
    Cons

    • Expensive as fuck. Seti is $11/day @ 2g/day and PGE2 is about $1.40/day @ 1mg/EOD
    • You might notice its hard to stay asleep for the first week. It goes away though.

    ----------------------------------------------------------------------------------------------------

    My Current Regimen

    • 1g Setipiprant taken orally every 12hrs
    • 1mg Prostaglandin E2 in 3ml of distilled water applied topically to scalp after very lightly microneedling session (goal is not wounding or to draw blood and should not be painful!). I usually do this every 2-3 days.
    Edit: Im also taking 2400mg/day of n-acetylcysteine as a bonus treatment since its really cheap and easy to get and it supposedly stops the crosstalk between PGD2 and testosterone in the hair follicle.

    Also Im not sure if this helps at all but Im also on nofap.
    ----------------------------------------------------------------------------------------------------

    Thoughts

    This has been a looong ride with a lot of tinkering and trial and error. I can say that all of the growth is from pge2+microneedling. Seti is only for maintenance and a prerequisite for pge2 to work. For pge2 to work you must also microneedle before applying it.

    I made a huge mistake in assuming that seti would be enough and all that was needed to get regrowth. I can not stress how important both are (Seti+pge2) and it makes sense since Allergan the company thats doing trials for seti is also doing trials for bimatoprost a PGF2α agonist.

    Im making really good gains still. The areas where I had hair but were thinning (my vertex area) are extremely thick now. im 100% satisfied for those areas.

    As for my temples and crown where i had severe hairloss its filling in very nicely.

    EDIT: You dont have to wait 2 year for these results.

    Almost all of the regrowth have been in the last 3 months because of the PGE2+microneedling I added.

    Seti alone will only give you maintenance and why I got a lot of flack for posting updates with minimum results over the last 2 years since people were expecting solid regrowth (I did Seti alone for a while and then I did PGE2 in ethanol topically but in hindsight it turns out the PGE2 in ethanol didnt do much now that I recently started with PGE2+microneedling)

    Like i said it was all trial and error and it looks like Im finally on to something with the PGE2+microneedling

    ------------------------------------------------------------------------------------------------------------------

    Resources

    Setipiprant FAQ


    Microneedling + Prostaglandin E2 FAQ
     
    #1 westonci, May 5, 2018
    Last edited: Jul 10, 2018
    veneno, dermrafok, Capone and 11 others like this.
  2. Afro_Vacancy

    Afro_Vacancy Senior Member My Regimen

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    I thought that the bimatoprost trials were dead?

    Thank you for documenting things. Some of us supported you financially, and you rewarded that by doing your part, and documenting your progress.
     
  3. westonci

    westonci Experienced Member

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    #3 westonci, May 5, 2018
    Last edited: May 5, 2018
    DHTcel, RegenWaiting and Afro_Vacancy like this.
  4. Afro_Vacancy

    Afro_Vacancy Senior Member My Regimen

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    No.

    What do you think about Braincels? I'm not sure if it suits me. It would also be another time sink.
     
  5. barfacan

    barfacan Experienced Member

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    What form of PGe2, how often? i recall reading about wildly varying half-lives between the different forms.
     
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  6. westonci

    westonci Experienced Member

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    Yea the incel shitposting is addicting. I love triggering normies especially with the roast beef posts
     
  7. Afro_Vacancy

    Afro_Vacancy Senior Member My Regimen

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    Sorry, but, ... what is a roast beef post?
     
  8. westonci

    westonci Experienced Member

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    CAS: 363-24-6

    should look like this

    Daily or every 2 days right after a very light microneedling session (should not be painful or uncomfortable! Your goal is not wounding!)

    [​IMG]
     
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  9. aemxle

    aemxle New Member

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    Hei @westonci , thanks for your update. Very usefull. One question:
    What do you think about the topical use of setipiprant? I talk about an high concentration, using salted setipiprant, like 10 or 15 %. Thank you.
     
  10. Falsenine

    Falsenine Established Member My Regimen

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    @westonci There is visible regrowth, no doubt!
    Thank you for your contribution and your efforts despite the negative comments.
    btw, can we see a picture of the temples?
     
  11. Pigeon

    Pigeon Senior Member My Regimen

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    Hail the king!

    Maintenance is confirmed with this regiment, that's for sure.

    Let's hope the seti trials results will show the same.
     
  12. INT

    INT Senior Member

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    Decent results that price is way too ridiculous to be a proper alternative, even if it would be only half the price.
     
  13. Pigeon

    Pigeon Senior Member My Regimen

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    Tell that to all the people afflicted with post fina issues.
     
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  14. INT

    INT Senior Member

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    I am one of them, what about it?
     
  15. Pigeon

    Pigeon Senior Member My Regimen

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    If money is an issue then know that we'll have fevi in 2019 (if all goes well)

    But if you have the money and think this is too expensive for a sideless maintenance treatment then you're probably not that concerned with your hairloss.

    Expensive treatment > cheap treatment that fcks with your hormones.
     
  16. aexit

    aexit Member My Regimen

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    300 per month for 2 years? rly? O_O
     
  17. westonci

    westonci Experienced Member

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    You dont have to wait 2 year for these results.

    Almost all of the regrowth have been in the last 3 months because of the PGE2+microneedling I added.

    Seti alone will only give you maintenance and why I got a lot of flack for posting updates with minimum results over the last 2 years since people were expecting solid regrowth (I did Seti alone for a while and then I did PGE2 in ethanol topically but in hindsight it turns out the PGE2 in ethanol didnt do much now that I recently started with PGE2+microneedling)

    Like i said it was all trial and error and it looks like Im finally on to something with the PGE2+microneedling
     
    #17 westonci, May 5, 2018
    Last edited: May 5, 2018
  18. aexit

    aexit Member My Regimen

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    Where can I get PGE2 from?
     
  19. westonci

    westonci Experienced Member

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    #19 westonci, May 5, 2018
    Last edited: May 5, 2018
  20. whatevr

    whatevr Senior Member My Regimen

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    You're really childish and annoying in Seti threads. What's your problem? Jaded that it doesn't regrow a NW1?
     

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