squeegee
Banned
- Reaction score
- 132
Novan's Clinical Trial Demonstrates Effective Anti-acne Property of SB204 by Reducing Sebum
SpecialChem - Jun 4, 2013
DURHAM, N.C. -- Novan Therapeutics has announced results from a recent clinical trial demonstrating that nitric oxide releasing drug candidate SB204 reduces colonization of the acne causing bacteria Propionibacterium acnes (P. acnes) in the skin of healthy volunteers. This study in combination with Novan's earlier findings regarding sebum production, suggests the formulation may be capable of targeting multiple factors in acne.
The Phase 1, thirty-subject study was conducted by Dr. James Leyden (KGL, Inc.). This predictive human model has been used to demonstrate the activity of anti-acne therapies like traditional oral antibiotics and topical antibiotics such as clindamycin. In this study, twice daily administration of the topical product was safe and "the treatment was extremely well tolerated," added Dr. Leyden. Several subjects demonstrated a greater than 90 percent reduction of P. acnes when treated with SB204; no vehicle-treated subjects exhibited such a response. A statistically significant difference (p < 0.05) in P. acnescounts was observed between active and vehicle after two weeks.
Acne is the most common skin disease in the United States, affecting more than 50 million people. Antibiotics have been a mainstay for dermatologists due to the ability to reduce P. acnes colonization in the skin and the documented ability to treat inflammatory lesions in acne patients. However, monotherapy usage of these drugs has slowed due to the onset of antibiotic resistance. Nitric oxide is an antimicrobial with a low propensity for resistance and is part of the human body's natural immune response to bacteria. "These unique properties of nitric oxide, in conjunction with the potential to reduce sebum, provide the basis for our belief that SB204 has the possibility to transform acne care," says Dr. Nathan Stasko, Novan President.
"I have always said the 'Holy Grail' of acne treatments would be a topical that can influence sebum production or the physicochemical properties of sebum. If you can do that, the ability to kill P. acnes is icing on the cake," said Dr. Leyden.
SB204 is currently being examined in a Phase 2 study for the treatment of acne. Results of that study are expected early 2014.
wait for it....................................................................................................................................................................................................................http://www.ncbi.nlm.nih.gov/pubmed/23493539Alcohol dependence is a major disease burden of adults in modern society worldwide. There is no cure for alcohol dependence. In this study, we have examined the molecular targets of ethanol-induced toxicity in humans based on a systematic review of literature data and then discussed current and potential therapeutic targets for alcohol abuse and dependence. Using human samples with ethanol exposure, microarray analyses of gene expression have shown that numerous genes are up- and/or down-regulated by alcohol exposure. The ethanol-responsive genes mainly encode functional proteins such as proteins involved in nucleic acid binding, transcription factors, selected regulatory molecules, and receptors. These genes are also correlated with important biological pathways, such as angiogenesis, integrin signalling pathway, inflammation, wnt signaling pathway, platelet-derived growth factor signaling pathway, p53 pathway, epidermal growth factor receptor signaling pathway and apoptosis signaling pathway. Currently, only three medications were approved by the U.S. Food and Drug Administration (FDA) for the treatment of alcohol abuse and alcohol dependence, including the aldehyde dehydrogenase inhibitor disulfiram, the micro-opioid receptor antagonist naltrexone, and the N-methyl-D-aspartate (NMDA) receptor inhibitor acamprosate (oral and injectable extended-release formulations). In addition, a number of agents are being investigated as novel treatments for alcohol abuse and dependence. These include selective 5-hair transplant reuptake inhibitors (e.g. fluoxetine), 5-hair transplant(1) receptor agonists (e.g. buspirone), 5-hair transplant(2) receptor antagonists (e.g. ritanserin), 5-hair transplant(3) receptor antagonists (e.g. ondansetron), dopamine receptor antagonists (e.g. aripiprazole and quetiapine), dopamine receptor agonists (e.g. bromocriptine), GABA(B) receptor agonists (e.g. baclofen), and cannabinoid-1 (CB(1)) receptor antagonists. Some of these agents have shown promising efficacy in initial clinical studies. However, further randomized studies with larger samples are warranted to establish their efficacy and safety profiles in the treatment of alcohol dependence.
.......................and there you have it.What do the Atkins Diet and the traditional Japanese diet have in common? The Atkins Diet is low in carbohydrate and usually high in fat; the Japanese diet is high in carbohydrate and usually low in fat. Yet both work to promote weight loss. One commonality of both diets is that they both eliminate the monosaccharide fructose. Sucrose (table sugar) and its synthetic sister high fructose corn syrup consist of 2 molecules, glucose and fructose. Glucose is the molecule that when polymerized forms starch, which has a high glycemic index, generates an insulin response, and is not particularly sweet. Fructose is found in fruit, does not generate an insulin response, and is very sweet. Fructose consumption has increased worldwide, paralleling the obesity and chronic metabolic disease pandemic. Sugar (i.e., fructose-containing mixtures) has been vilified by nutritionists for ages as a source of "empty calories," no different from any other empty calorie. However, fructose is unlike glucose. In the hypercaloric glycogen-replete state, intermediary metabolites from fructose metabolism overwhelm hepatic mitochondrial capacity, which promotes de novo lipogenesis and leads to hepatic insulin resistance, which drives chronic metabolic disease. Fructose also promotes reactive oxygen species formation, which leads to cellular dysfunction and aging, and promotes changes in the brain's reward system, which drives excessive consumption. Thus, fructose can exert detrimental health effects beyond its calories and in ways that mimic those of ethanol, its metabolic cousin. Indeed, the only distinction is that because fructose is not metabolized in the central nervous system, it does not exert the acute neuronal depression experienced by those imbibing ethanol. These metabolic and hedonic analogies argue that fructose should be thought of as "alcohol without the buzz."
Is there anything that molecule can't do??? Good find squeeg'!!
There is reason that guy won a Nobel prize for his working in NO...In the meantime, I'll continue to wash down those two huge glasses of beet juice a day...it makes you feel pretty damn good and it gives your face a rosy glow -- must be helping somewhat with your scalp
Happy now? lol you own me a grasshoper on tap at the Druides :beer:
- - - Updated - - -
well, I'll be happy when we have something to apply -- then you might get that beer ;-)
- - - Updated - - -
..ummm, now we're blaming fructose??? Let's keep this thread on track...humans evolved on fruits just as much as they did on meat...
...cutting back your fruit intake won't help now, even if it is linked..
well.... that would explain why humans have always been bald/balding even before agriculture. What do macaque eat? Also, fruit + booze + western diet is a WHOLE lot of influence on all those pathways and microRNA mentioned in the prior link. Heck, what if during pregnancy, an expectant mother eats a whole bunch of fruit and pasta? What if her mother before her did that? I'm not say'n....I'm just say'n.:dunno:
" and at the same time it could be explain the specific model of hair loss, because it does not affect the sides of head because this area does not occur alterations in sebum flow, creation and elimination of fat.
...at that point, we're damn near there....if anyone can explain why the sides don't bald but the top does, then bingo...need more on this angle...
"I have always said the 'Holy Grail' of acne treatments would be a topical that can influence sebum production or the physicochemical properties of sebum. If you can do that, the ability to kill P. acnes is icing on the cake," said Dr. Leyden.
Dr. Jame J Leyden is a good investigator about acne during decades, from early 70`s. He clearly talks about the “physicochemical properties of sebum” Acne and common hairloss are linked in my idea.
I think that the modification of sebum flux acts as a trigger in common hair loss. Sebum is altered passing the time, it is important that sebaceous gland produce sebum but it is necessary that this sebum can be remove from the scalp and pilosebaceous unit. I have also the idea that sebum not only dischard towards the surface of the scalp, Sebum is not only directed outwards but can travel into the hair follicle. In this narrow zone, sebum meets the stem cells and melanocytes. If can be confirmed this assumption, then we can explain the miniaturization of hair loss before the terminal lost of it, and at the same time it could be explain the specific model of hair loss, because it does not affect the sides of head because this area does not occur alterations in sebum flow, creation and elimination of fat.
...at that point, we're damn near there....if anyone can explain why the sides don't bald but the top does, then bingo...need more on this angle...
from Armando's post:" I have also the idea that sebum not only dischard towards the surface of the scalp, Sebum is not only directed outwards but can travel into the hair follicle."
The sides do thin, the areas where the frames of my glasses touch the head are thin in a very obvious vertical line till the back of the ear. I think my hair loss is a mix of male pattern baldness with something else that I haven't found any info since the same happens on my legs, the areas where the socks end are hairless. The only common thing is sebum, I think the glasses touching the head and socks (etc..) compress the sebum into the pores or block it causing inflammation and killing the follicle. Sebum and bacteria/fungus shouldn't be overlooked, not the cause but can cause damage in the male pattern baldness region.
Karl Pilkington has thinning on the sides too, google him up.
what are your thoughts on the paper Dr. Kelce presented in squeegee's link? what are your thoughts on sb204 based on your theory?
- - - Updated - - -
http://www.emaxhealth.com/1020/52/33685/topical-cream-studied-erectile-dysfunction.html
I wonder what happened with that...
Nitric Oxide with Cialis?.. I have pure Nitrate in a topical form.. and that stuff is so powerful.. I cannot even tolerate it at small dose..it goes in the bloodstream within 2 minutes.. then look like Dracula for 3 days LOL..