Topical Dutasteride Case Assessment Thread

jd_uk

Senior Member
Reaction score
302
Interesting read, most of it we already know but still:

https://www.reddit.com/r/tressless/comments/nhp467
"Therefore if we assume that topical finasteride does not absorb through the skin and therefore does not go systematic then we can also assume that it does little to inhibit circulating DHT so in theory it would do little to prevent the progression of androgenic alopecia."

Wtf. Is it just me who finds this paragraph pretty stupid? The whole point of topical finasteride is not to systemically inhibit circulating DHT but to inhibit it in the scalp/follicle.

I don't doubt that most of these formulations 'go systemic', but the selling point is that they're not supposed to (at least not to the extent of the oral pill).
 

trialAcc

Senior Member
My Regimen
Reaction score
1,331
"Therefore if we assume that topical finasteride does not absorb through the skin and therefore does not go systematic then we can also assume that it does little to inhibit circulating DHT so in theory it would do little to prevent the progression of androgenic alopecia."

Wtf. Is it just me who finds this paragraph pretty stupid? The whole point of topical finasteride is not to systemically inhibit circulating DHT but to inhibit it in the scalp/follicle.

I don't doubt that most of these formulations 'go systemic', but the selling point is that they're not supposed to (at least not to the extent of the oral pill).
Yeah but who's selling point is that? How many of those people actually tested their serum DHT before/after. I'm guessing not many.

They actually did trials on topical finasteride in Europe, and If I'm not mistaken they noted that 10-20% still goes systematic. Once you use it everyday this builds up in your tissue just the same as oral and accomplishes the same affect.
 

sparta03

Member
My Regimen
Reaction score
16
Ofc a large part of topical Fina still goes systemic there is no controverse in this statement. Still some guy who got bad sides on oral fina get better with topical. I don’t know if it’s just placebo or there is a real mechanism behind it
 

jd_uk

Senior Member
Reaction score
302
Interesting read, most of it we already know but still:

https://www.reddit.com/r/tressless/comments/nhp467
Another part of this post which is stupid:

"still present an attractive possibility for a combination therapy of topical Dutasteride combined with a low dose of an oral 5AR inhibitor to slightly reduce circulating DHT without significant risk of side effects."

Someone tell me what dose of oral 5ar inhibitor ehich can only slightly reduce circulating DHT. Finasteride has a flat dose response curve and builds up in the body. If there is an amount of oral finasteride which only lowers circulating DHT by around 20-25% (even after months of use), then I'd be interested in hearing it. But I'm not convinced such a dose exists. I've never seen anyone take measurements for this (which is frustrating in itself).
 

jd_uk

Senior Member
Reaction score
302
Yeah but who's selling point is that? How many of those people actually tested their serum DHT before/after. I'm guessing not many.

They actually did trials on topical finasteride in Europe, and If I'm not mistaken they noted that 10-20% still goes systematic. Once you use it everyday this builds up in your tissue just the same as oral and accomplishes the same affect.
It's the selling point of anyone who sells topical finasteride. And the people who use it believe that it 'doesn't go as systemic'. From my point of view if it lowers DHT to the same extent as the oral pill then it's a pointless method of delivery...in fact it's actually risky to those around us like partners and children who we come into contact with either directly or indirectly (when the finasteride rubs off on bed sheets, furniture etc). Again, people should have done a load of before/after tests for DHT to find a solution and dose which doesn't go systemic, but nobody ever did.
 

jd_uk

Senior Member
Reaction score
302
Ofc a large part of topical Fina still goes systemic there is no controverse in this statement. Still some guy who got bad sides on oral fina get better with topical. I don’t know if it’s just placebo or there is a real mechanism behind it
Placebo unless DHT levels are somehow less reduced with some formulations of topical finasteride. Again, this is the stupidity of the hair loss community because nobody ever pushes for studies based on hormone levels and instead just guesses based on 'sides'.
 

Mustang

Experienced Member
My Regimen
Reaction score
383
Why the f*** would you take 0.5mg orally every 14 days to keep circulating hormones low when only 5% of DHT actually circulates in your bloodstream. With the half-life of 5 weeks of Dutasteride that will cause inevitable side effects if you are prone to them.
 

Btg

Experienced Member
My Regimen
Reaction score
535
The problem is that the starting point of his thoughts, is that circulating dht is the sole reason for hair loss, which seems to go against literature. So the post makes little sense
 

hairloss_user

Experienced Member
My Regimen
Reaction score
773
I never thought I would ever touch finasteride or dutasteride, but topical dutasteride does sound promising. I am a little tempted to try it. Before I do I would definitely get a bloodtest. One question, how likely is it that I would develop gyno if trying this once a week at 0.1 strength? Honestly gyno side is my boggest concern. And how long should I wait to take the second blood test after the first application? What are normal dht levels?
 

losingbattle88

Established Member
My Regimen
Reaction score
121
Yep, I believe @sonictemples has success with this method
I think he meant oral duta every 14 days like the guy wrote in his post. and sonictemples only use topical 0.5mg once weekly not oral as far as im aware. and sonictemples even use a generic dutasteride pill that he mixes himself with alcohol, generic drugs works just the same as brand name drugs. im done ordering topical dutasteride from these money hungry companies overpriced bullshit, and my package is stuck in US for a long *** time now im from europe cant deal with this sh*t.
 
Last edited:

Liqurt

Member
My Regimen
Reaction score
8
I’m thinking of starting topical dutasteride

do I use minoxodil max or strut?

a new tressless topical dutasteride transformation was posted today and he said to stay away from minoxodilmax.. I wanted to order minoxodilmax cause it’s easier and without prescription

https://www.reddit.com/r/tressless/comments/nhwj4k
So strut or minoxodilmax..?
 
Last edited:

losingbattle88

Established Member
My Regimen
Reaction score
121
tbh scalp DHT dont seem to mean that much, finasteride orally only reduce scalp dht by 40% and serum by 70%. DESPITE only reducing scalp DHT by 40%, it STILL has stopped and even reversed balding for MANY people without even using minoxidill, I mean litteraly thickening and regrowth just by using oral finasteride. this proves that serum DHT has a rather big factor in hairloss.
 

losingbattle88

Established Member
My Regimen
Reaction score
121
I’m thinking of starting topical dutasteride

do I use minoxman or strut?

a new tressless topical dutasteride transformation was posted today and he said to stay away from minoxidil man.. I wanted to order minoxidil man cause it’s easier and without prescription

https://www.reddit.com/r/tressless/comments/nhwj4k
So strut or minoxman..?
not only easier but TWICE as cheap. and that guy was proably mustang xD lol. u can totally trust minoxidillmax, sure they use drugs from china and it may not be as "pure" but I think if their products made people bald or worsened their hair you would see hundreds of people complaining about their products all over the forums WHICH ISNT THE CASE AT ALL. they have been in business for years and I did personally use their sprio cream 5% and it reduced my shedding quite abit. I have read many positive comments of their products and I doubt all of them are written by their company staff. I personally wont buy from them but im gonna try out generic dutasteride pill and mix it myself like sonictemple does it will save me alot of money each month.
 

Liqurt

Member
My Regimen
Reaction score
8
not only easier but TWICE as cheap. and that guy was proably mustang xD lol. u can totally trust minoxidillmax, sure they use drugs from china and it may not be as "pure" but I think if their products made people bald or worsened their hair you would see hundreds of people complaining about their products all over the forums WHICH ISNT THE CASE AT ALL. they have been in business for years and I did personally use their sprio cream 5% and it reduced my shedding quite abit. I have read many positive comments of their products and I doubt all of them are written by their company staff. I personally wont buy from them but im gonna try out generic dutasteride pill and mix it myself like sonictemple does it will save me alot of money each month.
Do I get the pg free one or pg one from minoxidil max? Not sure which to get since I think there’s a pg free one and a pg one
 

Mustang

Experienced Member
My Regimen
Reaction score
383
Do I get the pg free one or pg one from minoxidil max? Not sure which to get since I think there’s a pg free one and a pg one

It's got DMI. Might as well take an oral pill of Dutasteride.

Twice as cheap? Paying Parati costs me 30 euros for 0.1% ... they are way cheaper than that crap

"U can totally trust a brand that uses Wuhan's dutasteride, the same that Kane used an tested 50% impute.

Sure man. Be my guest. Don't say we didn't warn you.
 

nico76

Member
My Regimen
Reaction score
8
Interesting read, most of it we already know but still:

https://www.reddit.com/r/tressless/comments/nhp467
Yep, I believe @sonictemples has success with this method

This page shows my concern about dutasteride. Fertility was reduced in subjects and was only partially rectified 24 weeks after stopping the drug:

The whole interest based around topical duta is the idea that it does not go systemic. If it doesn't go systemic (or only minimal amount) its not going to affect fertility.
 
Top