Hey all,
Just wanted to share a new small molecule being developed by TechoDerma medicines. They are trialing their drug TDM-105795 / TMI-105795 to treat androgenic alopecia and is actually in phase 1 unlike many other companies which can't seem to get out of pre-clinical.
They've already dosed a few people. They don't really scream and shout about their drug, they're just silently getting on with it so not a lot of information to share.
I've had a glance through the detailed patent and here's what I understood:
TDM-105795 / TMI-105795 is classified as a thyroid receptor stimulant and they state that it “could change hair growth cycle and promote hair growth”. They don’t divulge on those details as to whether it’s prolonging anagen or reducing telogen phase etc.
The vehicle they used is ethanol and pg (70:30) ratio. The chemical structure is available from the patent too.
Their phase 1 dosing consists of the following: "Single dose administration of TDM-105795 Topical Solution, 0.0025% or 0.005% or 0.01%"
All in all, lets hope they have a successful phase 1 and hoping to see more information revealed about this small molecule.
TechnoDerma Medicines Pipeline: http://tkskin.com/en/index.php?a=lists&catid=24
Phase 1 dosing announcement: http://tkskin.com/en/index.php?a=shows&catid=16&id=15
Phase 1 clinical trial registry: https://clinicaltrials.gov/ct2/show/NCT04913519?term=TDM-105795&draw=2&rank=1
Vague Patent: https://patents.google.com/patent/JP6444487B2/en
Detailed Patent: https://patents.google.com/patent/EP3181556A1/en
Just wanted to share a new small molecule being developed by TechoDerma medicines. They are trialing their drug TDM-105795 / TMI-105795 to treat androgenic alopecia and is actually in phase 1 unlike many other companies which can't seem to get out of pre-clinical.
They've already dosed a few people. They don't really scream and shout about their drug, they're just silently getting on with it so not a lot of information to share.
I've had a glance through the detailed patent and here's what I understood:
TDM-105795 / TMI-105795 is classified as a thyroid receptor stimulant and they state that it “could change hair growth cycle and promote hair growth”. They don’t divulge on those details as to whether it’s prolonging anagen or reducing telogen phase etc.
The vehicle they used is ethanol and pg (70:30) ratio. The chemical structure is available from the patent too.
Their phase 1 dosing consists of the following: "Single dose administration of TDM-105795 Topical Solution, 0.0025% or 0.005% or 0.01%"
All in all, lets hope they have a successful phase 1 and hoping to see more information revealed about this small molecule.
TechnoDerma Medicines Pipeline: http://tkskin.com/en/index.php?a=lists&catid=24
Phase 1 dosing announcement: http://tkskin.com/en/index.php?a=shows&catid=16&id=15
Phase 1 clinical trial registry: https://clinicaltrials.gov/ct2/show/NCT04913519?term=TDM-105795&draw=2&rank=1
Vague Patent: https://patents.google.com/patent/JP6444487B2/en
Detailed Patent: https://patents.google.com/patent/EP3181556A1/en
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