- Reaction score
- 373
Interview with Stemson Therapeutics CEO Geoff Hamilton – Follicle Thought
www.folliclethought.com
it is extremely challengelingI like that they are thinking of starting trials in countries other than the US primarily japan or south korea, i also like this
"some cases it could be a complimentary drug which supports the development of our hair follicles and could actually have better efficacy than what’s on the market.
We make a lot of these cells so we have a unique platform to test drug candidates on these cells which no one else has. So, it’s something on our minds. There are all sorts of ways that we can manipulate these cells through drug molecules to either upregulate activity or downregulate, if you wanted to get rid of armpit hair, or back hair, for example. So, there is a list of opportunities in front of us, but we’re not actually working on those yet, we’re solely focused on the breakthrough of making new hair follicles. "
because this is really a solid opportunity they do indeed have.
they also commented on what I made a post on two days ago, the DHT sensitivity question of their newly produced cells. they said they have not looked into this at this point but i think its good that they have it in mind and are working with real samples of patients with AA, they definitely have this on the map and who knows, this research might advance the understanding of AA as a whole, i think it obviously will because to make a cell that is dht resistent you really have to understand what constitutes that and then actually make the cells enter this kind of epigenetic program which i dont understand how one would even accomplish that. like, can you force an expression pattern onto a cell manually? after all thats exactly what programming an IPC is all about, just with different genes, not those that are upregulated to give a cell pluripotency but those who make it resistant to dht... sounds EXTREMELY challenging
with all due respect foggy but you know too little about biology to talk in such tones. lol, like you actually think people at this lab do not know what you are tlaking about? do you even know what gives a cell there identity? how they are able to remain in lineage during proliferation? if what you say is true, stem cells could not exist, they proliferate and lose their identity, every cell would be pluripotent then. dermal papilla cells do in fact have stem cell properties that means that they can proliferate quite often and they can differentiate into other cells down a given line. when they proliferate(and die), their indentity is being passed on to the daughter cells. for example, you have reduced expression of the androgen receptor. how is this achieved? for example by methylation of the promotor of the AR gene(this is what can be found in the safe donor zone). when the cells devide mitotically, this pattern is being passed on to the daughter cell in this case for example by an enzyme called Methyltransferasen. this is a example of epeginetics, a modification to the genome without actually changing the genome. this way, cells can have an identity and the important part is that this identity is being passed on to the daughter. this is why for example a liver cell which can devide over the course of its life does not suddenly become a brain cell when it proliferates. now, this is the same with genes that dont affect the indentity. it is the same process."
First, I think this is a fascinating approach. Second, I think it will eventually fail.
If the approach works, they will generate new follicles successfully. The new follicles would be implanted without rejection, because, like microfollicular hair transplants, they originate from cells harvested from the patient. I suspect this will be a very expensive process (low-medium five figures).
Unfortunately, they will not overcome “DHT resistance” on a permanent basis. That’s because sensitivity to DHT, with consequent signaling to miniaturize the follicle, is a property of the androgen receptors in the dermal papilla cells. Androgenetic Alopecia sufferers are burdened with too many due to their genetics. The Stemson Therapeutics folks are very talented and are likely to generate dermal papilla cell linings of their follicles with a lower concentration of androgen receptors. The problem is that these, cells, like all others, will die. They will be replaced by cells having the original concentration of androgen receptors, and the pattern baldness will recur. The net result will be a need to repeat this process a number of times over the patient’s lifetime.
I don’t think Stemson will have that much trouble getting over the genetic modification “hurdle” with the FDA or other regulatory body. The bigger problem will be that body’s requirement for Stemson to advertise clearly that this is a temporary solution."
By the time this would be out , the AR degrader would be out so it might not be a problem"
First, I think this is a fascinating approach. Second, I think it will eventually fail.
If the approach works, they will generate new follicles successfully. The new follicles would be implanted without rejection, because, like microfollicular hair transplants, they originate from cells harvested from the patient. I suspect this will be a very expensive process (low-medium five figures).
Unfortunately, they will not overcome “DHT resistance” on a permanent basis. That’s because sensitivity to DHT, with consequent signaling to miniaturize the follicle, is a property of the androgen receptors in the dermal papilla cells. Androgenetic Alopecia sufferers are burdened with too many due to their genetics. The Stemson Therapeutics folks are very talented and are likely to generate dermal papilla cell linings of their follicles with a lower concentration of androgen receptors. The problem is that these, cells, like all others, will die. They will be replaced by cells having the original concentration of androgen receptors, and the pattern baldness will recur. The net result will be a need to repeat this process a number of times over the patient’s lifetime.
I don’t think Stemson will have that much trouble getting over the genetic modification “hurdle” with the FDA or other regulatory body. The bigger problem will be that body’s requirement for Stemson to advertise clearly that this is a temporary solution."
1. They will get investors when they meet their milestone."There are several problems with this therapy
I don’t mean the effectiveness of the drug
The first is funding because they need money for research
As we all know who thinks to give money in research wants the money invested very quickly and not in 10 years.
It’s the economy.
Another problem when they publish therapy for alopecia
because it is a very demanding process
It will be many years before clinics are trained for this type of treatment"
Nah, he said many things you ignored.Another thing that we need to keep in mind is that "clinical trials" really mean different things for Stemson vs. the other hair loss companies.
When Histogen/Follica/Shiseido/etc. start a clinical trial, what they are *really* doing is trying to find out if their stuff works or not.
With Stemson is different. When they start their clinical trials they will already know their product works, because by then they will be already growing human hairs in animals with human skin.
So Stemson starting clinical trials will basically mean: we know it works, we just want to prove it is safe on humans and nothing goes unexpectedly (and maybe test some different protocols for optimization reasons).
That is why I'm not that disappointed that Stemson still doesn't have a clear date to start the clinical trials. Because I know that once they announce that it will probably mean they are confident they have the cure ready.
Not ignoring, that is why they haven't announced clinical trials yet. Because once they solve the problems you mentioned, they will start the trials. That is the point of what I wrote: that clinical trials will mean that they have solved most if not all the problems they are currently working on.Nah, he said many things you ignored.
1. They still need to learn how to control the hair quality.
2. The hair is still not dht restitent
3. They probbly know how to do it “by hands” but they trying to find a way to scale this thing up.
4. The hair probbly dosent survive many cycle which is the part he mention is chalenge not to lose the cells the produce the hair, which is way you saw the hair on mice but who know how many cycle the hair survived…
If it is dht resistant doesn't mean too much to me. The ability to clone the hair is more important.You guys are freaking out too much about the dht thing. Even if their hairs end up not being dht resistant (and that is a big if), I wouldn't mind doing maintenance refills every 5-10 years or so on my NW0 scalp I will get thanks to them.
They more far away then ppl think.If it is dht resistant doesn't mean too much to me. The ability to clone the hair is more important.
We already have dutasteride/finasteride and probably others products as resources in the near future to handle with hair loss. What we need is something to "regrowth" perfectly I think.
What he said in last interview? Anything realted to the guarantee something or reduced the time expectation to they go to the next step in their timeline? Or it was just about an improvement in their model to test the cloned hair?
He didn't mention any timelines. I think they are having good progress but he is playing safe with his words now. They just raised their series A so they have no reason to hype things up now (except maybe for hiring purposes). Geoff mentioned in the interview that he is focusing mostly on internal company stuff now.If it is dht resistant doesn't mean too much to me. The ability to clone the hair is more important.
We already have dutasteride/finasteride and probably others products as resources in the near future to handle with hair loss. What we need is something to "regrowth" perfectly I think.
What he said in last interview? Anything realted to the guarantee something or reduced the time expectation to they go to the next step in their timeline? Or it was just about an improvement in their model to test the cloned hair?