Stemson is going to use minipigs in the next stage of their hair cloning research

badnewsbearer

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Like I understand from video presentation they already tested the technology on pigs and have high confidence that this will work on humans. Correct me if I am wrong.


they testes kn pigs but not high confixenxe yet, they said once they do have high confidenxe they will do a B funding and woek towards trials
 

coolio

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What specifically would you like me to clarify?

Skull expansion = hair loss? Come on.

It's a longstanding theory and it's never had scientific support. Just elaborate ideas built out of correlations.
 

Raccooner

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Skull expansion = hair loss? Come on.

It's a longstanding theory and it's never had scientific support. Just elaborate ideas built out of correlations.
I think the argument makes plenty of sense. Tight scalp due to the skull's expansion leads to constriction of the capillaries which are needed to supply blood to the follicles. If this is bogus then how is it that in trans women the skull shape remodels, shrinks in shape or size and miraculously the hairline often returns? The only other argument would be hormonal change. Getting the needed blood supply to the hair follicles is crucial to their thickness and long-term survival. If you still think what I am telling you is theoretical bull, then tell me please. What causes pattern hair loss to occur?
 
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losingbattle88

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I think the argument makes plenty of sense. Tight scalp due to the skull's expansion leads to constriction of the capillaries which are needed to supply blood to the follicles. If this is bogus then how is it that in trans women the skull shape remodels, shrinks in shape or size and miraculously the hairline often returns? The only other argument would be hormonal change. Getting the needed blood supply to the hair follicles is crucial to their thickness and long-term survival. If you still think what I am telling you is theoretical bull, then tell me please. What causes pattern hair loss to occur?
The cure is apparently needling. It forces the body to send a rush of blood to the area and folicles. Seen too many cases of hair regrowth from needling. Why you arent doing it boggles my mind.
 

Raccooner

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The cure is apparently needling. It forces the body to send a rush of blood to the area and folicles. Seen too many cases of hair regrowth from needling. Why you arent doing it boggles my mind.
I definitely want to do it. The problem is if doing it incorrectly could lead to scarring. Have you tried microneedling for hair regrowth and did you see any improvement? What size needle do you use and how long did it take to notice signs of improvement?
 

Raccooner

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I dont know about you guys but I want a mini pig now..
I want a pet kiwi bird.
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losingbattle88

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I definitely want to do it. The problem is if doing it incorrectly could lead to scarring. Have you tried microneedling for hair regrowth and did you see any improvement? What size needle do you use and how long did it take to notice signs of improvement?
Scarring can happen but if it does happen its minor. You just need to do it correctly. I prefer stamp as it goes in straight and up straight. Roller Arent safe to use it tears up the skin. I actually comitted to start it again for the long haul this time, I too was scared of scarring but im Still balding on dutasteride so im Giving it a chance. If you dont go so deep with the needle and only do it once a week or twice a week to let skin heal then scarring Will probably not happen at all. The deeper the wound the higher chance of scarring i believe.
 

Joxy

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they testes kn pigs but not high confixenxe yet, they said once they do have high confidenxe they will do a B funding and woek towards trials
I watched the video second time and I didn’t hear anywhere that they said the confidence is not high.

CEO told that they are still doing trials on pigs and when they will be pretty sure that everything works fine, then they will move to human clinical trials...

Plus, he told that they are planning soon to hire more people. Around 25 in total, so that is pretty good news.
 

Joxy

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I am pretty sure that by the first half of this year they will know how this technology translates to pigs and if everything is working perfectly fine, and if not how to improve it.

It is very positive news that they started the pig trials and planning to hire more people. Probably they have some inside info how technology works so far...
 

pegasus2

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I think the argument makes plenty of sense. Tight scalp due to the skull's expansion leads to constriction of the capillaries which are needed to supply blood to the follicles. If this is bogus then how is it that in trans women the skull shape remodels, shrinks in shape or size and miraculously the hairline often returns? The only other argument would be hormonal change. Getting the needed blood supply to the hair follicles is crucial to their thickness and long-term survival. If you still think what I am telling you is theoretical bull, then tell me please. What causes pattern hair loss to occur?

When the AR and PRLR are activated it inhibits Wnt signalling and a series of gene transcription changes occur that affect cell ashesion and migration, apoptosis and proliferation. Head shape doesn't matter in the process of Androgenetic Alopecia. The threshold at which these gene transcription changes occur becomes lower with age.

The same molecular signalling changes that occur in the scalp concurrently take place in the prostate where there is no tension nor lack of blood flow. In the prostate it leads to bph and in the scalp it leads to Androgenetic Alopecia
 
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trialAcc

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When the AR and PRLR are activated it inhibits Wnt signalling and a series of gene transcription changes occur that affect cell ashesion and migration, apoptosis and proliferation. Head shape doesn't matter in the process of Androgenetic Alopecia. The threshold at which these gene transcription changes occur becomes lower with age.

The same molecular signalling changes that occur in the scalp concurrently take place in the prostate where there is no tension nor lack of blood flow. In the prostate it leads to bph and in the scalp it leads to Androgenetic Alopecia
I think the mapping of the skull probably plays a role in the area affected, but it's not the cause. I have no idea how/why, but it makes sense due to the cross over between tension/loss regions.
 

Raccooner

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When the AR and PRLR are activated it inhibits Wnt signalling and a series of gene transcription changes occur that affect cell ashesion and migration, apoptosis and proliferation. Head shape doesn't matter in the process of Androgenetic Alopecia. The threshold at which these gene transcription changes occur becomes lower with age.

The same molecular signalling changes that occur in the scalp concurrently take place in the prostate where there is no tension nor lack of blood flow. In the prostate it leads to bph and in the scalp it leads to Androgenetic Alopecia
So what is the point or biological advantage for this occurring in men? Why does this occur and why should it occur?
 

badnewsbearer

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we should not forget that even if stemson makes progress, this is something for our children(which I will never have anyway) and not for us. nobody cares that they get their hair back in their 40ties when they are in 20ties rn. stemson won't happen for another 10 years, the human trials alone can take an entire decade. hell, think about how long Cassiopeia has been running CB through trial. a whopping 12 years from initial human trials and there is no end in sight. what about regenerative medicine approaches? replicel has been trialing RCH-01 for more than a decade, no end in sight. if the end is in sight add another 2 years market entry period to it
 

badnewsbearer

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So what is the point or biological advantage for this occurring in men? Why does this occur and why should it occur?
MPHL is a degenerative gene defect. the only reason ti has not been wiped out completely is because most men go bald after they get children. if baldness occurred at 25 in the mean then the gene would be banished as it should be. I see baldness more like a disease and a defect than an evolutionary advantage, society does so as well
 

pegasus2

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I think the mapping of the skull probably plays a role in the area affected, but it's not the cause. I have no idea how/why, but it makes sense due to the cross over between tension/loss regions.

Why doesn't it happen to every man then? Why do women have a different pattern of hair loss despite having a different tension pattern? Why does the pattern in macaques not match their tension pattern? It doesn't even match on men, perhaps for some men. Different men have different balding patterns. If it plays any role it would be in Hox patterning in the womb, but this is irrelevant. Relieving scalp tension as an adult will do nothing to change that patterning, and when transplanting hairs from balding to non-balding areas the hairs last longer than the non-balding hairs did, they are permanent in most cases. This has been proven in humans and macaques. The scalp environment is not going to have any bearing on whether or not Stemson works unless it's scarred.
 

pegasus2

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we should not forget that even if stemson makes progress, this is something for our children(which I will never have anyway) and not for us. nobody cares that they get their hair back in their 40ties when they are in 20ties rn. stemson won't happen for another 10 years, the human trials alone can take an entire decade. hell, think about how long Cassiopeia has been running CB through trial. a whopping 12 years from initial human trials and there is no end in sight. what about regenerative medicine approaches? replicel has been trialing RCH-01 for more than a decade, no end in sight. if the end is in sight add another 2 years market entry period to it

You're comparing Stemson to Cassiopeia and Replicel. Enough said. If it takes them 12 years to get this in the clinic that's an abysmal failure
 

pegasus2

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So what is the point or biological advantage for this occurring in men? Why does this occur and why should it occur?
The human genome clearly isn't perfect. The Pax gene associated with Androgenetic Alopecia is also associated with reduced risk of scoliosis is women. The androgen receptor is obviously needed by men. Baldness is just the unfortunate byproduct of otherwise beneficial adaptations, and something that there was little selective pressure to eliminate from the genome.
 

trialAcc

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The human genome clearly isn't perfect. The Pax gene associated with Androgenetic Alopecia is also associated with reduced risk of scoliosis is women. The androgen receptor is obviously needed by men. Baldness is just the unfortunate byproduct of otherwise beneficial adaptations, and something that there was little selective pressure to eliminate from the genome.
male pattern baldness also occurs to late in life for it to be eliminated via selective pressure. It's only modern times where people delay reproduction into their mid-20s+, nevermind 40+ where male pattern baldness is most prevalent
 
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