something new ?
- Thread starter ragsta
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TravisB
Guest
Right now Aderans, Histogen and Replicel are our closest hopes for a cure/better treatment.
It's only about a month until Replicel release their initial results. God, I can't wait, let's hope we'll be positively surprised!
It's only about a month until Replicel release their initial results. God, I can't wait, let's hope we'll be positively surprised!
There are different paths for male pattern baldness. A lot of guys have plenty of hair still and just need a way to keep hair and prevent hair loss with no major risks to their health. Propecia is something, but another treatment like ascj-9 or this might help make this a reality. Keeping hair will always be a much easier and cheaper option, but the problem is this option barely exists right now.
Regrowing hair is a different ball game and yes hair multiplication might be the best hope there, but you never know. Something could pop out of nowhere and regrow huge amounts of hair that they did not expect.
I have seen this story today on google news and its on numerous sites so its a credible new discovery I think. They also said some treatments using this are already in progress like for asthma.
Regrowing hair is a different ball game and yes hair multiplication might be the best hope there, but you never know. Something could pop out of nowhere and regrow huge amounts of hair that they did not expect.
I have seen this story today on google news and its on numerous sites so its a credible new discovery I think. They also said some treatments using this are already in progress like for asthma.
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TravisB
Guest
There were some important discoveries in the last several years, maybe we'll finally be able to see the cure for baldness in our lifetime?
http://www.bbc.co.uk/news/health-17457098
It says there are drugs in clinical trials that target this pathway. Anyone know what they are? Who will be the first guinea pig?
It says there are drugs in clinical trials that target this pathway. Anyone know what they are? Who will be the first guinea pig?
casperz
Experienced Member
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Plenty of great info on Cotsarelis and what his team is trying to do, maybe we can experiment on our own. Its a good read.
http://www.faqs.org/patents/app/20110021599#b
http://www.faqs.org/patents/app/20110021599#b
Aspirin affects COX-1, we need COX-2 if I remember correctly.
According to the patent,
PGD2 synthase was detected as 17 pg/mg of tissue in haired scalp and 75.5 pg/mg in bald scalp, representing a 4.4 fold increase in bald tissue. PGD2A was also higher in bald scalp. PGE2 showed the opposite, levels were higher in hairy scalp than in bald scalp.
GPR49 (LGF5, HG38), another leucine rich repeat-containing protein, is found in hairy scalp. L-Leucine anyone?
According to the patent,
PGD2 synthase was detected as 17 pg/mg of tissue in haired scalp and 75.5 pg/mg in bald scalp, representing a 4.4 fold increase in bald tissue. PGD2A was also higher in bald scalp. PGE2 showed the opposite, levels were higher in hairy scalp than in bald scalp.
GPR49 (LGF5, HG38), another leucine rich repeat-containing protein, is found in hairy scalp. L-Leucine anyone?
Merk has a drug called Laropiprant, it inhibits PGD2, reducing the amount flushing that occurs when taking niacin. In one study, the flavanoid quercetin was also used to reduce PGD2 levels in niacin flush.
http://www.ncbi.nlm.nih.gov/pubmed/18831918
http://www.ncbi.nlm.nih.gov/pubmed/18831918
I suggest reading a few different stories about this and not just one. It really highlights how the media way over hypes stories when they have little real information.
I read a few articles where they flat out claimed this discovery was a cure for male pattern baldness. It clearly is nowhere near that this is the more realistic result that they found a new receptor and no one knows what the results will really be.
Whether blocking the GPR44 receptor would allow the regrowth of hair after balding -- or just prevent balding in the first place -- remains an open question. It also remains to be seen whether inhibiting the receptor would have any effect in humans.
I read a few articles where they flat out claimed this discovery was a cure for male pattern baldness. It clearly is nowhere near that this is the more realistic result that they found a new receptor and no one knows what the results will really be.
Whether blocking the GPR44 receptor would allow the regrowth of hair after balding -- or just prevent balding in the first place -- remains an open question. It also remains to be seen whether inhibiting the receptor would have any effect in humans.
Niacin produces pgd2, so would products like revivigen that contain niacin as a active ingredient cause hairloss? also would coffee and energy drinks wich are high in niacin cause hairloss? Been looking for this answer for some time now i just got revivogen and dont want to use it because of the niacin in it, i do get a slight burning sensation after application, i figure it is the niacin. any help would be appreciated.