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3 month update from me on Kane’s Seti. Not too many sides at all really unnoticeable for me however it’s done literally zero for my hair . Not sure if my batch was fake as well.
Setipiprant Does Work, But Only On Really Really High Doses.
- Thread starter westonci
- Start date
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The sleep-related issues have been widely reported by setipiprant users.
fully agree. the standard makes the nmr test easier and cheaper. but still unavoidable.
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Actually, i don't think it's a supplier related issue.
Prostaglandin D2's role in the sleep regulation system has been fairly known since 1988, it's a a physiological regulator of sleep in mammalians' brains.
Identified as a sleep-inducing substance, so feeling tired is not uncommon, i guess taking in before going to bed should do the trick, not in the morning.But nonetheless it will definetly be a common side effect of this treatment, impurity is not related.
Prostaglandin D2 and sleep/wake regulation. - NCBI
https://www.ncbi.nlm.nih.gov/pubmed/22024172
Prostaglandin D2 and sleep--a molecular genetic approach. - NCBI
https://www.ncbi.nlm.nih.gov/pubmed/10389108
Prostaglandin D2 in sleep-wake regulation: recent progress
https://www.ncbi.nlm.nih.gov/pubmed/11843094
Prostaglandins and adenosine in the regulation of sleep
https://www.ncbi.nlm.nih.gov/pubmed/17129762
Prostaglandin D2, a cerebral sleep-inducing substance in monkeys
www.pnas.org/content/85/11/4082.full.pdf
1988, shieeeeeeetttt that's old
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Forgot to mention that you have CRTH2 receptors in your brain aswell, so taking an antagonist like Seti or Fevi will have some effects
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Damn, We just need this but topical and hoping it will not go systemic. I don't understand how pharmaceutical choose the vehicle and the drugs. I mean, what the fuc... was thinking Merck ! " O sure, we can kill the main androgen in men but not problem at all, cause I saw some hermaphrodites withous DHT and they are alive ! " . Hope Allergan is not making the same mistake.
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I don't know for sure, only thing i know is that CRTH2 PGD2 receptors have been identified in brain.
And that PGD2 have a sleep regulation role in brain, wheter it's related i don't know, can be...
I really hope it's not, and opposed to Fina/Duta side effects, it's not that bad actually.
Like you said, what the f*** was Merck thinking
Hoping a topical PGD2 compound like the one Follica is working on should negate these potential sides
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DP2/CRTH2
Tiredness vs Sexuals Probs. Choose your field boys
Tiredness vs Sexuals Probs. Choose your field boys
Dont care all pale to being bald
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To everyone asking about sleep issues, no I've not had any sleep issues, but that's possibly because I take it right before I go out for the day. I would recommend that to anyone taking seti as well. 800mg/day btw
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Actually first Kythera trial seems to point the opposite.
Setipiprant's side-effects reported in trials were: dry mouth, nausea, somnolence, hepatic enzyme elevation, and anxiety.
Quote comes from slideshow from Kythera before Allergan bought it, seems it's not sleep disorder but somnolence, so like i mentioned before, taking it before going to bed seems fair, taking it in the morning could lead to somnolence through the day aka tiredness.
Try to retrieve these slides but no luck so far, i remember side effects rate were quite low anyway
Setipiprant's side-effects reported in trials were: dry mouth, nausea, somnolence, hepatic enzyme elevation, and anxiety.
Quote comes from slideshow from Kythera before Allergan bought it, seems it's not sleep disorder but somnolence, so like i mentioned before, taking it before going to bed seems fair, taking it in the morning could lead to somnolence through the day aka tiredness.
Try to retrieve these slides but no luck so far, i remember side effects rate were quite low anyway
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But the Hepatic Elevation and somnolence was lower than the placebo. Thanks to post the link, pretty interesting.
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IIRC, pgd2 was responsible for deep sleep. so the reason for tiredness is that u didnt get enough of deep sleep. thats why it is recommended not to take seti before bed.
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Yeah, you may be right.
That's a damn good question dude, i know antihistamines like cetirizine do in a little amount tho, but as for Seti, i really don't know