Samumed Sm04554 Results Normalized To Baseline

[Seuxin]

Btw, don't forget an important thing...this study is ONLY with the SM04554... :

No Anti Androgen
No Needling/wounding
No growth factors

Adding this to a regimen is a unlcoked door to the hair follicle neogenesis.

 

[-G-]

Why waiting for the release ? You can already buy it 1gr and at 0.15% it will last you long time.

Where would you buy it from ?

 

[jamesbooker1975]

If you look into their Phase 3 study they aim at NH 3V - 4 which looks like to focus on the vertex area (which phase 2 called NH4 most optimal). Just like Minoxidil is most effective on those areas.

So could be interesting if its only a vertex topical, and doesn't work on temples, or they just are focusing on the best results with their optimum group which is NH4

Everything that works on Vertex works on temples, is just that it works better for regrowth on the vertex, like minodixil or any other drug. Even Fiansteride works better on Vertex. Temple hairs , once it is lost, is much harder to regrew it.

 

[jamesbooker1975]

Why waiting for the release ? You can already buy it 1gr and at 0.15% it will last you long time.

Because it is homemade in soma house in China ?

 

[MrJolly26]

So, they give us an email:

clinicaltrials@samumed.com

Like that! Besides, they seem legit. Let´s see if 0.15% is better than 0.25%

 

[Mightyduck]

Because it is homemade in soma house in China ?

Agreed plus making a homemade topical solution is never reliable so chances are it could do more harm than good

 

[pegasus2]

Everything that works on Vertex works on temples, is just that it works better for regrowth on the vertex, like minodixil or any other drug. Even Fiansteride works better on Vertex. Temple hairs , once it is lost, is much harder to regrew it.

Part of that is because temple hairs are the first to go, and the longer they are gone the more fibrosis has set in, the more the APM is degraded, and the less stem cell proliferation you have when starting treatment. Add to that the higher levels of DHT in the frontal area, and you have a very difficult situation to treat. Temple loss can be treated exactly the same, it's just starting off from a worse position.

 

[Sanchez1234]

I have sm04 at home for half a year now. Problem is vehicle. Can dissolve it without DSMO and cant find the vehicle Samumed uses.

 

[NotInmywatch]

Part of that is because temple hairs are the first to go, and the longer they are gone the more fibrosis has set in, the more the APM is degraded, and the less stem cell proliferation you have when starting treatment. Add to that the higher levels of DHT in the frontal area, and you have a very difficult situation to treat. Temple loss can be treated exactly the same, it's just starting off from a worse position.

yes I agree I've seen transgender women with partially recovered temples (nuclear option)

 

[FilthyFrancis]

if everything goes to plan this will be available in turkey in 2021 We're getting close my hairloss brothers!!

Fingers crossed for 2021. Phase 2/3 in Turkey should end by H2 2020. Just give them time to unfold results and fill in the papers with Turkish health authority, so I would say late 2021 (IF SUCCESSFUL).

I have sm04 at home for half a year now. Problem is vehicle. Can dissolve it without DSMO and cant find the vehicle Samumed uses.

Surely we'll get a better vision on the appropriate vehicle once the patent is released

EDIT: I am really hyped about the fact that the new phase 2/3 trial in Turkey will last for 54 weeks!

 

[MrJolly26]

This is our only hope unless Follice releases/produces new drugs apart from the device they are developing.

Hope this shirt works and we can get it as soon as possible.

 

[Sanchez1234]

I will start sm04 tomorrow at 1.5mg per ml

 

[LifeIsSucks]

I will start sm04 tomorrow at 1.5mg per ml

are you using DMSO as a vehicle?

 

[Sanchez1234]

Pls make before / after Photos

I wont.
I am currently on DUTA 1.5mg with OH Flut and its not stopping my loss.
I know for sure if something works so will update accordingly but for research sake other people should try it

 

[FilthyFrancis]

I will start sm04 tomorrow at 1.5mg per ml

Just quoting one guy who actually posted an interesting comment on SM04554:
"As we have known for a long time the WNT-pathway is a main driver of cancer (a recent study can e.g. be found at https://www.ncbi.nlm.nih.gov/pubmed/28647886 ).
According to a recent Fierce Biotech article “Samumed’s drugs target CLK and DYRK, kinase enzymes that are upstream of the Wnt pathway” ( https://www.fiercebiotech.com/biotech/conversation-osman-kibar-ceo-samumed ). So they want to minimize the obvious WNT pathway-cancer risk.
But CLK is also involved in cancer development, so CLK-inhibitors are a promissing anti-cancer strategy (a recent study can be found at https://www.ncbi.nlm.nih.gov/pubmed/29769258 ). The same is true for DYRK : https://www.ncbi.nlm.nih.gov/pubmed/28554575"

-> Be cautious with experimental SM04554

 

[pegasus2]

Just quoting one guy who actually posted an interesting comment on SM04554:
"As we have known for a long time the WNT-pathway is a main driver of cancer (a recent study can e.g. be found at https://www.ncbi.nlm.nih.gov/pubmed/28647886 ).
According to a recent Fierce Biotech article “Samumed’s drugs target CLK and DYRK, kinase enzymes that are upstream of the Wnt pathway” ( https://www.fiercebiotech.com/biotech/conversation-osman-kibar-ceo-samumed ). So they want to minimize the obvious WNT pathway-cancer risk.
But CLK is also involved in cancer development, so CLK-inhibitors are a promissing anti-cancer strategy (a recent study can be found at https://www.ncbi.nlm.nih.gov/pubmed/29769258 ). The same is true for DYRK : https://www.ncbi.nlm.nih.gov/pubmed/28554575"

-> Be cautious with experimental SM04554

No problems in the trials, but 6 months is a short time for cancer to show up. I would definitely avoid this for now if you've ever had cancer or are at high risk.

Also, WAY-316606 avoids manipulating the Wnt pathway directly, instead inhibiting SFRP1 to allow normal WNT activation. It may be a safer option.

 

[Xander94]

Just quoting one guy who actually posted an interesting comment on SM04554:
"As we have known for a long time the WNT-pathway is a main driver of cancer (a recent study can e.g. be found at https://www.ncbi.nlm.nih.gov/pubmed/28647886 ).
According to a recent Fierce Biotech article “Samumed’s drugs target CLK and DYRK, kinase enzymes that are upstream of the Wnt pathway” ( https://www.fiercebiotech.com/biotech/conversation-osman-kibar-ceo-samumed ). So they want to minimize the obvious WNT pathway-cancer risk.
But CLK is also involved in cancer development, so CLK-inhibitors are a promissing anti-cancer strategy (a recent study can be found at https://www.ncbi.nlm.nih.gov/pubmed/29769258 ). The same is true for DYRK : https://www.ncbi.nlm.nih.gov/pubmed/28554575"

-> Be cautious with experimental SM04554

Wnt is lacking in scalp applying SM to scalp will restore it to regular levels in the scalp

so from inhibited WNT to regular WNT no cancer problem.

 

[FilthyFrancis]

Wnt is lacking in scalp applying SM to scalp will restore it to regular levels in the scalp

so from inhibited WNT to regular WNT no cancer problem.

I understand what you claim, and I believe in SM04554 treatment as much as you do.

One should just keep this information in mind when trying to go down the experimental route with this molecule. Personally, I would not risk it but in any case, be extra cautious with dosage and do not go beyond the .15% threshold.

 

[Xander94]

I understand what you claim, and I believe in SM04554 treatment as much as you do.

One should just keep this information in mind when trying to go down the experimental route with this molecule. Personally, I would not risk it but in any case, be extra cautious with dosage and do not go beyond the .15% threshold.

you wouldnt risk it cause its a shady untested chemicle from some chinaman.

 

[FilthyFrancis]

Interesting article on Samumed's founding and their CEO's past.

https://www.fiercebiotech.com/biotech/conversation-osman-kibar-ceo-samumed