Considering the fact that a number of studies have proven that Minoxidil (Rogaine) causes a decrease in collagen production, even if it is taken topically, due to its ability to penetrate the skin barrier and go systemic, I started to look at alternatives. My attention was immediately attracted to Stemoxydine. Despite the cost and decreased efficiency, it seems to me that Stemoxydine does not cause any reduction in collagen production. I myself, have no experience with this topical treatment, and I was wondering if anyone on this forum has used this topical for a prolonged period of time? I have looked up multiple other threads that discuss Stemoxydine, but the thing is that there are simply no reviews from long-term Stemoxydine users. I would really appreciate it if someone, preferably a long-term user, could share some of their experiences with this topical.
Questions regarding Stemoxydine (effectiveness, side effects, etc)
- Thread starter Hairstani
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- stemoxydine
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- 207
nothing beats th goat min in term of regrowth and stemox smells awfully bad
Minoxidil decreases collagen I deposition and tissue-like contraction in clubfoot-derived cells: a way to improve conservative treatment of relapsed clubfoot? - PubMed
Minoxidil exerts an <i>in vitro</i> inhibitory effect on the cell proliferation, collagen accumulation, and extracellular matrix contraction processes that are associated with clubfoot fibrosis. This study provides important preliminary results demonstrating the potential relevance of MXD for...
pubmed.ncbi.nlm.nih.gov
Lysyl Hydroxylase Inhibition by Minoxidil Blocks Collagen Deposition and Prevents Pulmonary Fibrosis via TGF-β₁/Smad3 Signaling Pathway - PubMed
BACKGROUND Idiopathic pulmonary fibrosis (IPF) is a deadly disease characterized by excessive collagen in the extracellular matrix (ECM) of the lungs. Collagen is the primary protein component of the ECM. However, the exact mechanisms underlying the formation and deposition of collagen in the...
pubmed.ncbi.nlm.nih.gov
Effects of minoxidil on cultured human skin fibroblasts - PubMed
Two important findings related to the effect of minoxidil on human skin fibroblasts in culture are reviewed. Treatment of cells with minoxidil is associated with a specific loss of lysyl hydroxylase activity; this loss occurs gradually and is reversed by removing minoxidil from the culture...
pubmed.ncbi.nlm.nih.gov
Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: implications for collagen cross-linking and treatment of fibrosis - PubMed
Collagen deposits in fibrotic lesions often display elevated levels of hydroxyallysine (pyridinoline) cross-links. The relation between the occurrence of pyridinoline cross-links and the irreversibility of fibrosis suggests that these cross-links contribute to the aberrant accumulation of...
pubmed.ncbi.nlm.nih.gov
Inhibitory effects of bFGF, VEGF and minoxidil on collagen synthesis by cultured hair dermal papilla cells - PubMed
Dermal papilla cells of rat vibrissa follicles cultivated in monolayers and in three-dimensional collagen gels show a different morphology in these culture systems. Dermal papilla cells cultured in lattices tend to express morphological features resembling those seen in vivo. Quantification of...
pubmed.ncbi.nlm.nih.gov
- Reaction score
- 207
Damn didn't know vegf decreasd collagen... why is it used in face cream Then?Minoxidil decreases collagen I deposition and tissue-like contraction in clubfoot-derived cells: a way to improve conservative treatment of relapsed clubfoot? - PubMed
Minoxidil exerts an <i>in vitro</i> inhibitory effect on the cell proliferation, collagen accumulation, and extracellular matrix contraction processes that are associated with clubfoot fibrosis. This study provides important preliminary results demonstrating the potential relevance of MXD for...Lysyl Hydroxylase Inhibition by Minoxidil Blocks Collagen Deposition and Prevents Pulmonary Fibrosis via TGF-β₁/Smad3 Signaling Pathway - PubMed
BACKGROUND Idiopathic pulmonary fibrosis (IPF) is a deadly disease characterized by excessive collagen in the extracellular matrix (ECM) of the lungs. Collagen is the primary protein component of the ECM. However, the exact mechanisms underlying the formation and deposition of collagen in the...Effects of minoxidil on cultured human skin fibroblasts - PubMed
Two important findings related to the effect of minoxidil on human skin fibroblasts in culture are reviewed. Treatment of cells with minoxidil is associated with a specific loss of lysyl hydroxylase activity; this loss occurs gradually and is reversed by removing minoxidil from the culture...Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: implications for collagen cross-linking and treatment of fibrosis - PubMed
Collagen deposits in fibrotic lesions often display elevated levels of hydroxyallysine (pyridinoline) cross-links. The relation between the occurrence of pyridinoline cross-links and the irreversibility of fibrosis suggests that these cross-links contribute to the aberrant accumulation of...Inhibitory effects of bFGF, VEGF and minoxidil on collagen synthesis by cultured hair dermal papilla cells - PubMed
Dermal papilla cells of rat vibrissa follicles cultivated in monolayers and in three-dimensional collagen gels show a different morphology in these culture systems. Dermal papilla cells cultured in lattices tend to express morphological features resembling those seen in vivo. Quantification of...
Does stemoxydine even work? I used it for a little didn't notice any change except my usual loss. If I recall correctly there's very few studies on it and the one that showed the best results seemed kinda shitty and was done by the company or funded by the company that owned it.
- Reaction score
- 138
I wouldn’t waste any money, time or faith in stemox.. oh wait, I already did...
Pick and choose from the effective traditional treatments. Those with substantial research behind them.
Pick and choose from the effective traditional treatments. Those with substantial research behind them.
- Reaction score
- 65
I understand that you want SAFE and effective treatment but when you are looking on efficiency/sides ratio minoxidil has one of the best ratio. plus look at the studies that you linked:Minoxidil decreases collagen I deposition and tissue-like contraction in clubfoot-derived cells: a way to improve conservative treatment of relapsed clubfoot? - PubMed
Minoxidil exerts an <i>in vitro</i> inhibitory effect on the cell proliferation, collagen accumulation, and extracellular matrix contraction processes that are associated with clubfoot fibrosis. This study provides important preliminary results demonstrating the potential relevance of MXD for...Lysyl Hydroxylase Inhibition by Minoxidil Blocks Collagen Deposition and Prevents Pulmonary Fibrosis via TGF-β₁/Smad3 Signaling Pathway - PubMed
BACKGROUND Idiopathic pulmonary fibrosis (IPF) is a deadly disease characterized by excessive collagen in the extracellular matrix (ECM) of the lungs. Collagen is the primary protein component of the ECM. However, the exact mechanisms underlying the formation and deposition of collagen in the...Effects of minoxidil on cultured human skin fibroblasts - PubMed
Two important findings related to the effect of minoxidil on human skin fibroblasts in culture are reviewed. Treatment of cells with minoxidil is associated with a specific loss of lysyl hydroxylase activity; this loss occurs gradually and is reversed by removing minoxidil from the culture...Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: implications for collagen cross-linking and treatment of fibrosis - PubMed
Collagen deposits in fibrotic lesions often display elevated levels of hydroxyallysine (pyridinoline) cross-links. The relation between the occurrence of pyridinoline cross-links and the irreversibility of fibrosis suggests that these cross-links contribute to the aberrant accumulation of...Inhibitory effects of bFGF, VEGF and minoxidil on collagen synthesis by cultured hair dermal papilla cells - PubMed
Dermal papilla cells of rat vibrissa follicles cultivated in monolayers and in three-dimensional collagen gels show a different morphology in these culture systems. Dermal papilla cells cultured in lattices tend to express morphological features resembling those seen in vivo. Quantification of...
-"Exposure to ≥0.5 mM MXD resulted in a decrease in collagen type I accumulation after 8 and 21 days in culture. "
-" were administered a minoxidil solution (30 mg/kg) by oral gavage... The anti-fibrotic effects of minoxidil may be mediated through competitive inhibition of LHs activity, resulting in decreased pyridine cross-link formation and collagen production and deposition"
-"there was approximately a 30% inhibition of collagen production with 5 ng/ml bFGF, 0.1 ng/ml VEGF and 100 ng/ml minoxidil."
Basicly minoxidil inhibit collagen production at very large doses. These concentration are barely achive with oral minoxidil for hair loss although for sure oral has higher chance of it.
- Reaction score
- 207
will 5mg of oral min cause those sides?and do you know ant way to counteract minoxidil skin sides except from retin a? thank you so much
- Reaction score
- 152
It shouldnt, even people that supposedly got skin aging as a side effect, never proved it with actual photos. Imo minoxidil aging skin is urban legend
- Reaction score
- 207
i got a twin brother that has been on huge topical dose of minoxidil for 8 years while i haven't used it consistantly and trust me his skin looks 10 years older than me and full of wrinkles
Post pictures. You don't have to show the entire face, just crow feet, under-eye area, and forehead.
- Reaction score
- 207
why would i lie about that my life is already shity enough .... and trust me i love minoxidil i respond well to the drugs it's just that it destroy my face each time i get back on it
I am sorry, I am genuinely interested. I am not accusing you of anything.
- Reaction score
- 45
I too am interested in a twin study on minoxidil
It is not really a study. More like a case study. We don't know if both twins had the same amount of UV exposure and other factors.