Potential Prostaglandin E2 Suppliers | HairLossTalk Forums

Potential Prostaglandin E2 Suppliers

Discussion in 'New Research, Studies, and Technologies' started by westonci, Mar 8, 2018.

  1. westonci

    westonci Established Member

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    Delete
     
    #1 westonci, Mar 8, 2018
    Last edited: May 7, 2018
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  2. BaldAsshole

    BaldAsshole Established Member My Regimen

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    Results with such treatment? It is just pure speculation?
     
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  3. Alex Contee

    Alex Contee Established Member My Regimen

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    Thanks for the info. I apologize if you mentioned this elsewhere but how did you land on 1mg/day? Also do you apply once or twice a day? Thanks again.
     
  4. ALightInTheDark

    ALightInTheDark Established Member My Regimen

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    Read Cotsarelis studies
     
  5. reyl

    reyl Established Member My Regimen

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    Are you taking it orally or topically?
     
  6. BaldAsshole

    BaldAsshole Established Member My Regimen

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    I think I had. Correct if I'm wrong, they showed that PGD2 was overexpressed in balding scalp, whereas PGE2 was underexpressed. This doesn't address my question, though. By this time, I believe that PGE2 administration has not been proven as an effective treatment in any group of patients; and, according to some, Brotzu for example (and I know that he is not the most trustworthy person at this point), PGE2 has been proven ineffective in experiments. The theory is interesting, but what about the empirical data?

    PGE2 has been linked to a number of diseases, including cancer

    Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4 receptor in endometrial cancer.
    https://www.ncbi.nlm.nih.gov/pubmed/27230680

    and its role as a treatment of male pattern baldness it is just based in speculation. Its plausible mechanisms of action are, as far as I know, not well understood, and the risks are far too great. At this point, I don't believe that it is wise to self-treat oneself with a pro-inflammatory prostaglandin, that could go systemic and break havoc in several parts of your body.
     
    #6 BaldAsshole, Mar 10, 2018
    Last edited: Mar 10, 2018
  7. reyl

    reyl Established Member My Regimen

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    PGD2 has to be reduced in addition to PGE2 being increased.
     
  8. HairCook

    HairCook Established Member My Regimen

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    Dont tell him, morons can shave or whatever at this point. :D
     
  9. HairCook

    HairCook Established Member My Regimen

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    The once dangerous here are untested chinese suppliers and uninformed human beings like you.
     
  10. BaldAsshole

    BaldAsshole Established Member My Regimen

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    I know the theory. Now, where is the empirical evidence? Do we have any subject that regrew his hair with this approach? Do we know whether it is safe to increase prostaglandins that have been linked to cancer? This prostaglandin theory has been around for a while, at least since 2013, when I first read about it in Longecity, where are the results in this 5 years?
     
    #10 BaldAsshole, Mar 10, 2018
    Last edited: Mar 10, 2018
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  11. BaldAsshole

    BaldAsshole Established Member My Regimen

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    Because I'm sceptic and I ask for evidence, I deserve to be called a moron, dangerous and uninformed, I see. Several times I stated that I may be wrong, that I only talk from my perspective, which could be limited. Anyway, I don't see how my request for evidence and my concern about safety could be undesirable. I have maintained my hair for the last decade with no sides, and some of the substances I take diminish in fact both PGD2 and PGE2, I have experienced no regrowth, I'm a NW1.5, with a little receding in the temples and a little thinning in the crown, every male in my family was bald at my age; some, long before. Now, tell me, why should I shave or why should I take something that has been linked extensively to cancer and disease. Because this follows almost the same reasoning that you people do. You say that PGE2 is low in the balding scalp, and therefore it should be increased. I say that PGE2 is high in tumors, and therefore increasing it MIGHT be a bad idea.
     
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  12. HairCook

    HairCook Established Member My Regimen

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    No, you demand to be spoonfed in an experimental treatment section. Obviously not the place for you.
     
  13. kiwipilu

    kiwipilu Experienced Member My Regimen

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    We already know that it should be safe and effective to tackle pgd2. (With topical ceti study). or other studies with people using anti histamines. But you are right for pge2, I don’t remember study showing it may be a safe approach or correct(if this makes sense?!);.

    True when you think about prostanglandins, it is quite funny tbh. It is known for more than 10years. The fact is every 2 years there is a new hype with new studies or new drug. Then You see some members buying the full package to give it a go. I 'm sure all drugs targeting pg’s have been tried at this point even natural plant extracts... from oc to seti and I would not be surprised some guys out there even tried (or are trying) fevipiprant… ^^
    Don't get me wrong I'm still hopeful but we just need a new effective drug to be released, a legit, safe, ready to use, f**** drug ; ) that said I have more hope in wounding+coumpound thoug
     
  14. furrydome

    furrydome Established Member My Regimen

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    Could you make a post about that, or even explain a little more? Seems like a pretty extreme step, would love to know your procedure.
     
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  15. Arrade

    Arrade Experienced Member My Regimen

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    What have you done to maintain? finasteride? At what dose
     
  16. Kornel

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    So, I think we should pick one supplier, do a GB and test pge2.

    But is anyone interested in a pge2 GB?
     
  17. sktboiboi

    sktboiboi Established Member My Regimen

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    i think u're the 1 that got it wrong here.

    He doesnt have to convince u or any1.

    He started this thread for those that have alrdy made up their mind
     
  18. alebaba

    alebaba Established Member

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    I'm using kane pge2, but honestly, I'm just taking a leap of faith. Even if you got it tested, its impossible to know if future buy will be legit as well.

    I like option 2 better. I'm down to do a group buy at 500$, we can do 5 ppl, 100$ each. Get it tested, if its garbage than w/e.
     
  19. Razor of Damocles

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    Think the 2nd option is better as well.
    If this goes through, group buying seti might be a viable option, and a way to bring the price down a bit.
     
  20. alebaba

    alebaba Established Member

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    I prefer eth becasue its faster than bitcoin but bitcoin would work as well.
     

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