Permanent brain damage from finasteride?

Feelsbadman

Senior Member
Reaction score
514
Wondering if anyone else has experienced this. I have never ever been the same person since i took the first dosage. It's like part of my brain has been shut off. Even when i had major depression i was still always interested in learning and talking to people and learning about things and places etc. It's like i felt so good just learning and understanding things. I even was really witty and was always making jokes and loved making people laugh and smile. Now it's like somethign in my brain has shut off. I never feel like this. I feel like i have been numbed. I no longer have interest in laerning or anytihng. No matter what i do. it's very scary will i ever go back to nrmal?
 

TanDoc

Member
My Regimen
Reaction score
16
Wondering if anyone else has experienced this. I have never ever been the same person since i took the first dosage. It's like part of my brain has been shut off. Even when i had major depression i was still always interested in learning and talking to people and learning about things and places etc. It's like i felt so good just learning and understanding things. I even was really witty and was always making jokes and loved making people laugh and smile. Now it's like somethign in my brain has shut off. I never feel like this. I feel like i have been numbed. I no longer have interest in laerning or anytihng. No matter what i do. it's very scary will i ever go back to nrmal?

If you feel like your mood is being affected while you're taking it, that's possible. However, finasteride by itself is highly unlikely to give you "permanent brain damage" like the title suggests. I'd suggest seeing a counselor or therapist if you're feeling depressed and you're no longer taking the drug.
 
Last edited:

LongJohnTom

New Member
My Regimen
Reaction score
6
Finn is dangerous as hell. I remember getting off of it immediately after my dick stopped working on it. I rather have my sanity over a perfect sub-par hairline.
 

Here For the Lulz

Established Member
My Regimen
Reaction score
112
It‘s known that it can permanently change your brains composition due to its effects on your hormonal balance, but I wouldn’t call that brain damage.
 

jamesbooker1975

Senior Member
My Regimen
Reaction score
952
Wondering if anyone else has experienced this. I have never ever been the same person since i took the first dosage. It's like part of my brain has been shut off. Even when i had major depression i was still always interested in learning and talking to people and learning about things and places etc. It's like i felt so good just learning and understanding things. I even was really witty and was always making jokes and loved making people laugh and smile. Now it's like somethign in my brain has shut off. I never feel like this. I feel like i have been numbed. I no longer have interest in laerning or anytihng. No matter what i do. it's very scary will i ever go back to nrmal?
Yes, it probably can happen. You are suppressing 70 % of a natural hormone that is in your body in normal range . PLus you are inhibit a lot more than just DHT, cause 5-alpha reductase is used for many reactions in our body, like convert pregnolone into allopregnolone.
There is a reason why Glaxo never release Dutasteride for Androgenetic Alopecia. They where much more ethics than Merck. If you want to know how Merck worked but the same time they marcket Propecia, read about the Vioxx Scandal.
 

MrPortugal

Experienced Member
My Regimen
Reaction score
240
When I used finasteride I felt like a zombie my brain was like in suspend mode.

The best treatment I use right now and works very well is if you want try

Minoxidil 1x every day and wash my head every day with ketoconazole 2% for 5-10 minutes.
 

SnortingFinasteride

Member
My Regimen
Reaction score
22
Yes, it probably can happen. You are suppressing 70 % of a natural hormone that is in your body in normal range . PLus you are inhibit a lot more than just DHT, cause 5-alpha reductase is used for many reactions in our body, like convert pregnolone into allopregnolone.
There is a reason why Glaxo never release Dutasteride for Androgenetic Alopecia. They where much more ethics than Merck. If you want to know how Merck worked but the same time they marcket Propecia, read about the Vioxx Scandal.
Isn't it 5AR Type 1 that is mainly responsible for the conversion of neurosteroids ? In your example : "pregnolone into allopregnolone"..




Also, since Finasteride inhibits 5AR type 2 and 3, and has insignificant effects on 5AR Type 1, i don't see how it can cause moderate to severe cognitive impairement (compared to Dutasteride for example). Unless experts found out that 5AR type 3 also plays a role in cognitive function, which is still unknown at this point.





And btw, Glaxo didn't go through the hassle of FDA's approval of Dutasteride for hairloss because they knew they wouldn't profit from it like Finasteride did for Merck. Yet if you go to Japan or Korea, dutasteride is widely prescribed for BPH + for hairloss. There are no "ethics" going on for multi-million dollar pharmaceutical companies, it is all about the money.
 

jamesbooker1975

Senior Member
My Regimen
Reaction score
952
Isn't it 5AR Type 1 that is mainly responsible for the conversion of neurosteroids ? In your example : "pregnolone into allopregnolone"..




Also, since Finasteride inhibits 5AR type 2 and 3, and has insignificant effects on 5AR Type 1, i don't see how it can cause moderate to severe cognitive impairement (compared to Dutasteride for example). Unless experts found out that 5AR type 3 also plays a role in cognitive function, which is still unknown at this point.





And btw, Glaxo didn't go through the hassle of FDA's approval of Dutasteride for hairloss because they knew they wouldn't profit from it like Finasteride did for Merck. Yet if you go to Japan or Korea, dutasteride is widely prescribed for BPH + for hairloss. There are no "ethics" going on for multi-million dollar pharmaceutical companies, it is all about the money.
Finasteride is a 5α-reductase inhibitor that blocks the biosynthesis of endogenous neurosteroids such as allopregnanolone and related 5α-reduced steroids
 

jamesbooker1975

Senior Member
My Regimen
Reaction score
952
Isn't it 5AR Type 1 that is mainly responsible for the conversion of neurosteroids ? In your example : "pregnolone into allopregnolone"..




Also, since Finasteride inhibits 5AR type 2 and 3, and has insignificant effects on 5AR Type 1, i don't see how it can cause moderate to severe cognitive impairement (compared to Dutasteride for example). Unless experts found out that 5AR type 3 also plays a role in cognitive function, which is still unknown at this point.





And btw, Glaxo didn't go through the hassle of FDA's approval of Dutasteride for hairloss because they knew they wouldn't profit from it like Finasteride did for Merck. Yet if you go to Japan or Korea, dutasteride is widely prescribed for BPH + for hairloss. There are no "ethics" going on for multi-million dollar pharmaceutical companies, it is all about the money.
"And btw, Glaxo didn't go through the hassle of FDA's approval of Dutasteride for hairloss because they knew they wouldn't profit from it like Finasteride did for Merck."
Hahahhhahahaahahahahaahahahahahhahaahhahahaahaha
Yes sure. A drug that can be take it only once a week and will give much, much better results than finasteride . haahahahhahahaahahahahahahahahahhahahahahahahahah
Yes dude, you are like a groupie of Propecia, not matter what they show you , you will ignore it.
4a5whQECMklEWswCcNC1981dKiCeW3ZwBYsUPYzx9yItg5g5k8.gif
 

SnortingFinasteride

Member
My Regimen
Reaction score
22

Attachments

  • dvdy23892-fig-0002-m.jpg
    dvdy23892-fig-0002-m.jpg
    81.7 KB · Views: 32

SnortingFinasteride

Member
My Regimen
Reaction score
22
"And btw, Glaxo didn't go through the hassle of FDA's approval of Dutasteride for hairloss because they knew they wouldn't profit from it like Finasteride did for Merck."
Hahahhhahahaahahahahaahahahahahhahaahhahahaahaha
Yes sure. A drug that can be take it only once a week and will give much, much better results than finasteride . haahahahhahahaahahahahahahahahahhahahahahahahahah
Yes dude, you are like a groupie of Propecia, not matter what they show you , you will ignore it.
View attachment 158603
Actually, the graph that you uploaded seems to correlate with the study that shows how 0.1 mg Dutasteride was as potent as 5 mg Finasteride. The study was done for a duration of only 6 months though.. Also, Dutasteride is not that potent than Finasteride, so, i don't know how you can say "a drug that can be taken only once a week will give much, much better results than finasteride" when clearly, that is not the case.. Maybe using your brain more often before typing would help you in future conversations.






Before spamming the "h" and "a" keys anymore than you already did, you should know that plethora of guys are already very scared from trying Finasteride, based on its sexual side effects. If you were to present a drug, theoretically stronger than Finasteride, and with logically more chances of sexual side effects + a very, very long half-life, would you think that it would generate more income than its "safer" sibling ?
 
Last edited:

jamesbooker1975

Senior Member
My Regimen
Reaction score
952
I was under the impression that neurosteroids is mainly synthesized with the help of 5AR Type 1, for which i am indeed correct.




I still don't get how Finasteride would affect that pathway, as it doesn't inhibit 5AR Type 1 (not to the extent of Dutasteride at least)..
First at all, Is not just DHT , This are all the reactions where 5-alpha reductase need it :
Second "I was under the impression that neurosteroids is mainly synthesized with the help of 5AR Type 1 " That is what Merck told us and was just pure propaganda. To understand how Merck works, search about the Vioxx Scandal.
 

Pigeon

Senior Member
My Regimen
Reaction score
4,094
Actually, the graph that you uploaded seems to correlate with the study that shows how 0.1 mg Dutasteride was as potent as 5 mg Finasteride. The study was done for a duration of only 6 months though.. Also, Dutasteride is not that potent than Finasteride, so, i don't know how you can say "a drug that can be taken only once a week will give much, much better results than finasteride" when clearly, that is not the case.. Maybe using your brain more often before typing would help you in future conversations.






Before spamming the "h" and "a" keys anymore than you already did, you should know that plethora of guys are already very scared from trying Finasteride, based on its sexual side effects. If you were to present a drug, theoretically stronger than Finasteride, and with logically more chances of sexual side effects + a very, very long half-life, would you think that it would generate more income than its "safer" sibling ?
Dutasteride is more potent than fina, that's a fact.


Many new studies showing the effects of 5ar inhibitors on the cognitive system

The potential involvement of cholinergic system in finasteride induced cognitive dysfunction​

Abstract​


Objective: Neurosteroids are known to exert diverse functions in the brain. 5α-reductase (5α-R), a rate-limiting enzyme involved in the biosynthesis of neurosteroids is inhibited by finasteride. Clinical studies suggest that administration of finasteride causes the emergence of affective symptoms and cognitive dysfunction. Modeling this in rats would provide an opportunity to understand the mechanisms. Accordingly, in the present study, we evaluated the effects of repeated finasteride administration on spatial learning and memory in the partially baited radial arm maze task (RAM) and social cognitive behavior in the social interaction test. Further, to initiate the quest to understand the mechanisms underlying the effects of finasteride, in a separate group of animals, acetylcholinesterase (AChE) activity in the frontal cortex, hippocampus, septum and striatum was estimated.

Methods: 2 months old male Wistar rats were trained to learn a partially baited radial arm maze task (four trials per day till they reach a choice accuracy of 80 %). Following this, rats were administered with either vehicle (HPβCD) or finasteride (30 or 100 mg/Kg, s.c.) for 7 days and then subjected to retention test on the eighth day. To evaluate the social cognition, finasteride was administered for 7 days, followed by social interaction test on the eighth day. All the sessions were video-recorded and analyzed using Noldus Ethovision XT™ software. Following finasteride administration, on the eighth day, rats were euthanized, and AChE activity was estimated by modified Ellman's method.

Results: Finasteride (100 mg/Kg, s.c.) administration decreased the percent correct choice during the retention trial of the RAM task. This was paralleled by an increase in the number of total number of errors and reference memory errors. In the social interaction test, finasteride (100 mg/Kg, s.c.) administration decreased the time spent with the rat compared to the object, implying decreased sociability and diminished social preference evidenced by similar time spent with the novel and familiar rat. Reduced AChE activity was observed in the frontal cortex, hippocampus and septum.

Conclusion: Our study provides evidence that repeated administration of finasteride decreases social interaction and results in cognitive deficits, potentially through a cholinergic mechanism. Further studies are required to understand the exact link between the cognitive effects and the cholinergic system. A deeper probe of the current findings holds promise for the development of novel neurosteroid-based therapeutics to treat affective and cognitive disorders.



The Steroidogenesis Inhibitor Finasteride Reduces the Response to Both Stressful and Rewarding Stimuli​

Abstract

Finasteride (finasteride) is the prototypical inhibitor of steroid 5α-reductase (5αR), the enzyme that catalyzes the rate-limiting step of the conversion of progesterone and testosterone into their main neuroactive metabolites. finasteride is clinically approved for the treatment of benign prostatic hyperplasia and male baldness; while often well-tolerated, finasteride has also been shown to cause or exacerbate psychological problems in vulnerable subjects. Evidence on the psychological effects of finasteride, however, remains controversial, in view of inconsistent clinical reports. Here, we tested the effects of finasteride in a battery of tests aimed at capturing complementary aspects of mood regulation and stress reactivity in rats. finasteride reduced exploratory, incentive, prosocial, and risk-taking behavior; furthermore, it decreased stress coping, as revealed by increased immobility in the forced-swim test (FST). This last effect was also observed in female and orchiectomized male rats, suggesting that the mechanism of action of finasteride does not primarily reflect changes in gonadal steroids. The effects of finasteride on FST responses were associated with a dramatic decrease in corticotropin release hormone (CRH) mRNA and adrenocorticotropic hormone (ACTH) levels. These results suggest that finasteride impairs stress reactivity and reduces behavioral activation and impulsive behavior by altering the function of the hypothalamus-pituitary-adrenal (HPA) axis.


Treatment of male rats with finasteride, an inhibitor of 5alpha-reductase enzyme, induces long-lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation and gut microbiota composition​


Abstract​

Persistent alteration of plasma neuroactive steroid levels associated with major depression has been recently reported in men after the suspension of the treatment for androgenetic alopecia with finasteride, an inhibitor of the enzyme 5alpha-reductase. Observations in male rats confirmed persistent alterations in neuroactive steroid levels also in the brain. In the present study, we have ascertained possible effects on depressive-like behavior, neurogenesis, gliosis, neuroinflammation and gut microbiota in male rats after subchronic treatment for 20 days with finasteride and after one month of its withdrawal. At the end of treatment there was an increase in the number of pH3 immunoreactive cells in the subgranular zone of the dentate gyrus together with an increase in the mRNA levels of TNF-α in the hippocampus. By one month after the end of finasteride treatment, rats showed depressive-like behavior coupled with a decrease in the number of pH3 immunoreactive cells in the subgranular zone of the dentate gyrus, a decrease in granule cell density in the granule cell layer and an increase in the number of GFAP immunoreactive astrocytes in the dentate gyrus. Finally, alteration of gut microbiota (i.e., an increase in Bacteroidetes phylum and in Prevotellaceae family at the end of the treatment and a decrease in Ruminococcaceae family, Oscillospira and Lachnospira genus at the end of the withdrawal period) was detected.
In conclusion, finasteride treatment in male rats has long term effects on depressive-like behavior, hippocampal neurogenesis and neuroinflammation and gut microbiota composition.


Patients treated for male pattern hair with finasteride show, after discontinuation of the drug, altered levels of neuroactive steroids in cerebrospinal fluid and plasma.

Abstract


Observations performed in a subset of patients treated for male pattern hair loss indicate that persistent sexual side effects as well as anxious/depressive symptomatology have been reported even after discontinuation of finasteride treatment. Due to the capability of finasteride to block the metabolism of progesterone (PROG) and/or testosterone (T) we have evaluated, by liquid chromatography-tandem mass spectrometry, the levels of several neuroactive steroids in paired plasma and cerebrospinal fluid (CSF) samples obtained from post-finasteride patients and in healthy controls. At the examination, post-finasteride patients reported muscular stiffness, cramps, tremors and chronic fatigue in the absence of clinical evidence of any muscular disorder or strength reduction. Although severity of the anxious/depressive symptoms was quite variable in their frequency, overall all the subjects had a fairly complex and constant neuropsychiatric pattern. Assessment of neuroactive steroid levels in CSF showed a decrease of PROG and its metabolites, dihydroprogesterone (DHP) and tetrahydroprogesterone (THP), associated with an increase of its precursor pregnenolone (PREG). Altered levels were also observed for T and its metabolites. Thus, a significant decrease of dihydrotestosterone (DHT) associated with an increase of T as well as of 3?-diol was detected. Changes in neuroactive steroid levels also occurred in plasma. An increase of PREG, T, 3?-diol, 3?-diol and 17?-estradiol was associated with decreased levels of DHP and THP. The present observations show that altered levels of neuroactive steroids, associated with depression symptoms, are present in androgenic alopecia patients even after discontinuation of the finasteride treatment. This article is part of a Special Issue entitled 'Sex steroids and brain disorders'.


https://www.ncbi.nlm.nih.gov/pubmed/24717976

5α-reductase inhibitors really mess with your brain and has an effect on many neurosteroids, here's a nice graph showing only a part of the pathways it influences:

eohmsbfwmaajfx6-format-jpg-name-small-jpg.jpg


By inhibiting 5α-reductase and thus preventing DHT production, finasteride reduces androgen signaling in tissues like the prostate gland and the scalp. In the prostate, this reduces prostate volume, which improves BPH and reduces risk of prostate cancer. Finasteride reduces prostate volume by 20 to 30% in men with benign prostatic hyperplasia.[67] Inhibition of 5α-reductase also reduces epididymal weight, and decreases motility and normal morphology of spermatozoa in the epididymis.[68]

Neurosteroids like 3α-androstanediol (derived from DHT) and allopregnanolone (derived from progesterone) activate the GABAA receptor in the brain; because finasteride prevents the formation of neurosteroids, it functions as a neurosteroidogenesis inhibitor and may contribute to a reduction of GABAA activity. Reduction of GABAA receptor activation by these neurosteroids has been implicated in depression, anxiety, and sexual dysfunction.[69][70][71]


I'm sorry, fina and co aren't as innocent as you think they are.
 
Last edited:

whatintheworld

Senior Member
Reaction score
1,053
@Pigeon That is good information. Still, if you are in this situation, consider:

a) the potential side effects posted there or
b) the potential side effects of having nothing but a horseshoe left, and maybe even weakened donor so that you can't get a transplant.

Just imagine yourself in the situation of (b). Would you really be ok with that? It's easy to say, oh well I'll skip finasteride, I can deal with a little recession no big deal. If all I had was a little recession I never would have touched finasteride with a 10 foot pole.

Which is worse? Consider also:

if for (a), the probability of getting these is around 2%. Perhaps less if you do everything else lifestyle wise to minimize them, such as eating as healthy as you can, minimize stress, get adequate sleep, exercise, etc.

for (b) the probability is 100% guaranteed, for men who actually have aggressive hair loss, to happen.

Without finasteride I would 100% be guaranteed to be in the (b) category. The side effects of this would be depression, self loathing, brain fog, anxiety.

For me it was a no brainer to avoid the 100% certain side effects of option (b), and to start finasteride.
 
Top