Newly Discovered Factor in Androgenetic Alopecia. The Cure is Near?
- Thread starter yassin
- Start date
Re: A recently discovered new factor in AA, the cure is near 
prostaglandin d2 antagonist:
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A novel DP(2) receptor antagonist (AM-461): a patent evaluation of WO2011085033.
WO2011085033
http://www.bioportfolio.com/resources/p ... on-Of.html
http://www.ncbi.nlm.nih.gov/pubmed/22082220
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AM211
http://www.ncbi.nlm.nih.gov/pubmed/22110163
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MK-7246
http://www.ncbi.nlm.nih.gov/pubmed/20943773
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Ramatroban
http://www.ncbi.nlm.nih.gov/pubmed/15179446
I'm going to order this one very soon!
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http://en.wikipedia.org/wiki/Cromoglicic_acid
Guys, Please stop waisting your time on this one. I have not even 1 clear study that show its spupresses or block the PGD2, GPR44 receptor, You guys cant confuse prostanglandins with Histamine! If someone can prove I'm worng with a study, please do!
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We cant use cox2 blockers, because we will also reduce the pgE2 and pgF2... and we dont want that.
So Lets find a good PGD2, GPR44 antagonist!
Just found this intersting patent!:
http://www.google.com/patents/US2011002 ... &q&f=false
I'm Also very intersted in the CRTH2 antagonist OC000459
http://www.oxagen.co.uk/crth2-1.htm
http://www.chemspider.com/Chemical-Stru ... 37014.html
ITs one of the most selective and effective out there (from my findings)
I will arrange custom synthesises These weeks..
I think this is better then ramatroban!
prostaglandin d2 antagonist:
--------------------------------------------------------------------------------------------------------
A novel DP(2) receptor antagonist (AM-461): a patent evaluation of WO2011085033.
WO2011085033
http://www.bioportfolio.com/resources/p ... on-Of.html
http://www.ncbi.nlm.nih.gov/pubmed/22082220
--------------------------------------------------------------------------------------------------------
AM211
http://www.ncbi.nlm.nih.gov/pubmed/22110163
--------------------------------------------------------------------------------------------------------
MK-7246
http://www.ncbi.nlm.nih.gov/pubmed/20943773
--------------------------------------------------------------------------------------------------------
Ramatroban
http://www.ncbi.nlm.nih.gov/pubmed/15179446
I'm going to order this one very soon!
--------------------------------------------------------------------------------------------------------
http://en.wikipedia.org/wiki/Cromoglicic_acid
Guys, Please stop waisting your time on this one. I have not even 1 clear study that show its spupresses or block the PGD2, GPR44 receptor, You guys cant confuse prostanglandins with Histamine! If someone can prove I'm worng with a study, please do!
-------------------------------------------------------------------------------------------------------
We cant use cox2 blockers, because we will also reduce the pgE2 and pgF2... and we dont want that.
So Lets find a good PGD2, GPR44 antagonist!
Just found this intersting patent!:
http://www.google.com/patents/US2011002 ... &q&f=false
I'm Also very intersted in the CRTH2 antagonist OC000459
http://www.oxagen.co.uk/crth2-1.htm
http://www.chemspider.com/Chemical-Stru ... 37014.html
ITs one of the most selective and effective out there (from my findings)
I will arrange custom synthesises These weeks..
I think this is better then ramatroban!
tricospanish
New Member
- Reaction score
- 0
Re: A recently discovered new factor in AA, the cure is near
"prostaglandins are dysregulated in Androgenetic Alopecia, the most common type of hair loss in men. Specifically, PGD2 inhibits hair growth and thus represents a negative counterbalance to the positive effects on hair growth shown for PGE2 and PGF2?. Agents such as aspirin, which inhibit upstream prostaglandin synthesis enzymes (PTGS1 and PTGS2), have minimal effects on hair growth because of likely equally decreased production of PGE2 and PGD2."
"highly testosterone-responsive transcript, which further suggests its importance in Androgenetic Alopecia. PGD2 is thought to play a central role in male gonadal sex determination and is highly expressed in male genitalia. Similarly, Ptgds expression in the heart is regulated by estrogen. Estrogen leads to increases in 15-dPGJ2 levels in the uropygial gland."
"Given the androgens are aromatized into estrogens, these results may be relevant to hair growth and alopecia in men Thus, these or similar pathways might be conserved in the skin and suggest that sex hormone regulation of Ptgds may contribute to the pathogenesis of Androgenetic Alopecia"
"minoxidil alters potassium channel kinetics, it is also known to increase production of PGE2. Given the decreased amount of PGE2 present in bald scalp versus haired scalp, minoxidil may normalize PGE2 levels. Future studies should address whether minoxidil can concomitantly decrease PGD2 levels and thus normalize multiple prostaglandin species as a mechanism to improve Androgenetic Alopecia."
"supplemental PGE2 could be therapeutic. By correcting its deficiency and increasing its level in bald scalp, the inhibitory effects of PGD2 may be overcome. Analogs of PGF2?, which are already FDA-approved to promote eyelash growth, should also have similar effects on the scalp and are currently in clinical trials for this indication. Once issues of delivery, dosing, and safety are addressed, additional agonists and antagonists of prostaglandin pathways should become available.
"multiple mechanisms may be responsible for hair loss in Androgenetic Alopecia. Inhibiting PGD2 may prevent miniaturization and provide benefit to those in the process of balding; however, it is unclear whether men who are already bald will regrow hair."
Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia 2012
Luis A. Garza, Yaping Liu, Zaixin Yang, Brinda Alagesan, John A. Lawson, Scott M.Norberg, Dorothy E. Loy, Tailun Zhao, Hanz B. Blatt, David C. Stanton, Lee Carrasco,Gurpreet Ahluwalia, Susan M. Fischer, Garret A. FitzGerald, and George Cotsarelis
"prostaglandins are dysregulated in Androgenetic Alopecia, the most common type of hair loss in men. Specifically, PGD2 inhibits hair growth and thus represents a negative counterbalance to the positive effects on hair growth shown for PGE2 and PGF2?. Agents such as aspirin, which inhibit upstream prostaglandin synthesis enzymes (PTGS1 and PTGS2), have minimal effects on hair growth because of likely equally decreased production of PGE2 and PGD2."
"highly testosterone-responsive transcript, which further suggests its importance in Androgenetic Alopecia. PGD2 is thought to play a central role in male gonadal sex determination and is highly expressed in male genitalia. Similarly, Ptgds expression in the heart is regulated by estrogen. Estrogen leads to increases in 15-dPGJ2 levels in the uropygial gland."
"Given the androgens are aromatized into estrogens, these results may be relevant to hair growth and alopecia in men Thus, these or similar pathways might be conserved in the skin and suggest that sex hormone regulation of Ptgds may contribute to the pathogenesis of Androgenetic Alopecia"
"minoxidil alters potassium channel kinetics, it is also known to increase production of PGE2. Given the decreased amount of PGE2 present in bald scalp versus haired scalp, minoxidil may normalize PGE2 levels. Future studies should address whether minoxidil can concomitantly decrease PGD2 levels and thus normalize multiple prostaglandin species as a mechanism to improve Androgenetic Alopecia."
"supplemental PGE2 could be therapeutic. By correcting its deficiency and increasing its level in bald scalp, the inhibitory effects of PGD2 may be overcome. Analogs of PGF2?, which are already FDA-approved to promote eyelash growth, should also have similar effects on the scalp and are currently in clinical trials for this indication. Once issues of delivery, dosing, and safety are addressed, additional agonists and antagonists of prostaglandin pathways should become available.
"multiple mechanisms may be responsible for hair loss in Androgenetic Alopecia. Inhibiting PGD2 may prevent miniaturization and provide benefit to those in the process of balding; however, it is unclear whether men who are already bald will regrow hair."
Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia 2012
Luis A. Garza, Yaping Liu, Zaixin Yang, Brinda Alagesan, John A. Lawson, Scott M.Norberg, Dorothy E. Loy, Tailun Zhao, Hanz B. Blatt, David C. Stanton, Lee Carrasco,Gurpreet Ahluwalia, Susan M. Fischer, Garret A. FitzGerald, and George Cotsarelis
squeegee
Banned
- Reaction score
- 132
Re: A recently discovered new factor in AA, the cure is near
So do you really think dumbass that Prostaglandin is the only factor in male pattern baldness? tell me why most female from our society don't have male pattern baldness? haahhahahah Prostaglandin is totally an old f*****g news... Androgen is the main factor in male pattern baldness. you cannot go around it.. and you question is so irrelevant.. hahaha damn troll..Prostaglandin is pretty much the inflammation factor.. this is why progenitor cells cannot migrate...
2020 said:
So do you really think dumbass that Prostaglandin is the only factor in male pattern baldness? tell me why most female from our society don't have male pattern baldness? haahhahahah Prostaglandin is totally an old f*****g news... Androgen is the main factor in male pattern baldness. you cannot go around it.. and you question is so irrelevant.. hahaha damn troll..Prostaglandin is pretty much the inflammation factor.. this is why progenitor cells cannot migrate...
Re: A recently discovered new factor in AA, the cure is near
the zone where stem cells migrate is very narrow, so inflammatory events can do it worst, more difficult to travel, even more if exist hardened sebum in the "road". This is my idea, the same in women and men.
the zone where stem cells migrate is very narrow, so inflammatory events can do it worst, more difficult to travel, even more if exist hardened sebum in the "road". This is my idea, the same in women and men.
Re: A recently discovered new factor in AA, the cure is near
You could use any type of vehicle that will suite you skin type.
liquid/creme. It doesn't matter much at all from my experience.
I'm making a deal for ramatroban at the moment.
waynakyo said:
You could use any type of vehicle that will suite you skin type.
liquid/creme. It doesn't matter much at all from my experience.
I'm making a deal for ramatroban at the moment.
fighting-baldness
Member
- Reaction score
- 1
Re: A recently discovered new factor in AA, the cure is near
I really see this as something significant indeed. Let's hope this will finally the (main) reason to baldness. This will provide the best cure so far ... at least I am confident to think that.
There are a lot of companies working on baldness and science is improving every day.... It's a matter of time before a cure is founded. Things like this are important discoveries!
I really see this as something significant indeed. Let's hope this will finally the (main) reason to baldness. This will provide the best cure so far ... at least I am confident to think that.
There are a lot of companies working on baldness and science is improving every day.... It's a matter of time before a cure is founded. Things like this are important discoveries!
Re: A recently discovered new factor in AA, the cure is near
I'm still very intersted in the CRTH2 antagonist OC000459
http://www.oxagen.co.uk/crth2-1.htm
http://www.chemspider.com/Chemical-Stru ... 37014.html
http://www.google.com/patents/US20100041699
851723-84-7 5-Fluoro-2-methyl-3-quinolin-2-ylmethylindo-1-yl)-acetic
ITs one of the most selective and effective out there (from my findings)
I will arrange custom synthesises These weeks..
I think this is better then ramatroban! Because it wil NOT bind on the Thromboxane receptor, which worries me alot
Guys, I have a price quote. a gram of this HIGHLY selective CRTH2 antagonist WIll cost about 50-100 USD per GRAM. If we use like 1% solution. 1 gram will last +-4-6 months. (Like CB-03-01)
The supplier just needs to know if we are able to reach the minimum of 10 Gram before the start the production. It needs to be custom made and the assay will be 99%.
I will make a signup list, If we could get at least 10 intersted people, The supplier will start the production. This is no group order because anyone could order anytime from the directly supplier, its just a signup list to check if its worth for custom production.
LIST:
Boldy
I'm still very intersted in the CRTH2 antagonist OC000459
http://www.oxagen.co.uk/crth2-1.htm
http://www.chemspider.com/Chemical-Stru ... 37014.html
http://www.google.com/patents/US20100041699
851723-84-7 5-Fluoro-2-methyl-3-quinolin-2-ylmethylindo-1-yl)-acetic
ITs one of the most selective and effective out there (from my findings)
I will arrange custom synthesises These weeks..
I think this is better then ramatroban! Because it wil NOT bind on the Thromboxane receptor, which worries me alot
Guys, I have a price quote. a gram of this HIGHLY selective CRTH2 antagonist WIll cost about 50-100 USD per GRAM. If we use like 1% solution. 1 gram will last +-4-6 months. (Like CB-03-01)
The supplier just needs to know if we are able to reach the minimum of 10 Gram before the start the production. It needs to be custom made and the assay will be 99%.
I will make a signup list, If we could get at least 10 intersted people, The supplier will start the production. This is no group order because anyone could order anytime from the directly supplier, its just a signup list to check if its worth for custom production.
LIST:
Boldy
Re: A recently discovered new factor in AA, the cure is near
And now they even dropped Setipiprant for the new :
CRTH2 antagonist OC000459
http://www.oxagen.co.uk/crth2-1.htm
mlouis said:
And now they even dropped Setipiprant for the new :
CRTH2 antagonist OC000459
http://www.oxagen.co.uk/crth2-1.htm
LooseItAll
Established Member
- Reaction score
- 11
Re: A recently discovered new factor in AA, the cure is near
Acutally from my understanding selective cox-2 inhibitors work by surpressing bad prostaglandins while leaving the good ones PGE and PGF. But hey can also cause some cardiovascular problems but I am not sure if that applies to them being used topically
I am considering topical Celebrex myself. About 3g/1ml of solvent two types a day about 3 ml. So that would give about 20 mg maybe less for safety per day.
Boldy said:
Acutally from my understanding selective cox-2 inhibitors work by surpressing bad prostaglandins while leaving the good ones PGE and PGF. But hey can also cause some cardiovascular problems but I am not sure if that applies to them being used topically
I am considering topical Celebrex myself. About 3g/1ml of solvent two types a day about 3 ml. So that would give about 20 mg maybe less for safety per day.
Re: A recently discovered new factor in AA, the cure is near
NO,
supressing cox2, will also reduce PGE2! and other good prostaglandins like maybe PGF2a
If you do a cox2 inhibiator, you should ad topically PG2Fa, or PGE2. Like Bimatoprost.
LooseItAll said:
NO,
supressing cox2, will also reduce PGE2! and other good prostaglandins like maybe PGF2a
If you do a cox2 inhibiator, you should ad topically PG2Fa, or PGE2. Like Bimatoprost.
LooseItAll
Established Member
- Reaction score
- 11
Re: A recently discovered new factor in AA, the cure is near
Aye you are correct. COX-1 produces the base levels of prostaglandins. Obviousy that is ov no harm(I don't even know if COX-1 is present in the scalp.
Now COX-2 overexpression is induced by DHT, so that would explain why women are not that prone to androgenic alopecia. COX-2 is present in the inflammation sites, so we can safely assume that increased DHT levels in balding scalp lead to increase of COX-2 and that leads to increased levels of PGD2 and PGE2 but the deal is that obviously the excess PGE2 producton does not do us any favor otherwise we woudn't be balding. COX-2 also produces some other type of PGE2 called PGE2-G.
I think it is worth giving a shot till we don't have an easily available GPR44 inhibitor. But I agree an additional synthetic PGF2a could really help. Also minoxidil as long as it increases PGE2 levels through COX-1 not 2.
Boldy said:
Aye you are correct. COX-1 produces the base levels of prostaglandins. Obviousy that is ov no harm(I don't even know if COX-1 is present in the scalp.
Now COX-2 overexpression is induced by DHT, so that would explain why women are not that prone to androgenic alopecia. COX-2 is present in the inflammation sites, so we can safely assume that increased DHT levels in balding scalp lead to increase of COX-2 and that leads to increased levels of PGD2 and PGE2 but the deal is that obviously the excess PGE2 producton does not do us any favor otherwise we woudn't be balding. COX-2 also produces some other type of PGE2 called PGE2-G.
I think it is worth giving a shot till we don't have an easily available GPR44 inhibitor. But I agree an additional synthetic PGF2a could really help. Also minoxidil as long as it increases PGE2 levels through COX-1 not 2.
young trunks
New Member
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- 0
Re: A recently discovered new factor in AA, the cure is near
Hi all.. I am suffering extreme thinning at extreme rate.. What pgd2 is everybody recommending topically. I want to handle this and stop worrying so bad. People are making fun of me in my family......
But the eye drops are best recommended to block pgd2?
Hi all.. I am suffering extreme thinning at extreme rate.. What pgd2 is everybody recommending topically. I want to handle this and stop worrying so bad. People are making fun of me in my family......
But the eye drops are best recommended to block pgd2?
young trunks
New Member
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- 0
Re: A recently discovered new factor in AA, the cure is near
Topically? Does it effect dht internally?
squeegee said:
Topically? Does it effect dht internally?
Re: A recently discovered new factor in AA, the cure is near
further analysis of the mechanism of action of ramatroban has now been performed. PGD2-stimulated human eosinophil migration was shown to be mediated exclusively through activation of CRTH2, and surprisingly, these effects were completely inhibited by ramatroban!!!!!! I guess ramatroban + PGF2alpha (bimatropost) SHOULD mean FULL REGROWTH! (its what I hope!)I truely believe in it
http://jpet.aspetjournals.org/content/305/1/347.long
further analysis of the mechanism of action of ramatroban has now been performed. PGD2-stimulated human eosinophil migration was shown to be mediated exclusively through activation of CRTH2, and surprisingly, these effects were completely inhibited by ramatroban!!!!!!
I guess ramatroban + PGF2alpha (bimatropost) SHOULD mean FULL REGROWTH! (its what I hope!)I truely believe in ithttp://jpet.aspetjournals.org/content/305/1/347.long