New Studies Show Vit D Implicated In Hair Loss And Calcipotriol

[Medina]

Their resistance decreased below the point of their circulating androgens in certain amount of time. They may have already been gradually becoming more sensitive.

Sensitivity increases without the presense of androgens. Look at eunuchs when injected with testosterone, they reach whatever norwood level rapidly because androgen sensitivity increased even in the absense of androgens.

So the million dollar question is what happens to cause the sensitivity

Would it be worth researching ways to increase estrogen receptor ability in the scalp? I guess it would be useful since some of us are thinking of using estrogen to grow hair, and better receptors could mean less use?

 

[SpaceInvader]

The sensitivity is inherited. Genetic code that instructs to make follicles with high sensitivity.

 

[jphalo]

https://selfhacked.com/2016/01/13/n...itrol-and-vitamin-d-receptor-gene-expression/

It seems to match with everything that is said recently about inflammations and Tregs etc...

"Vitamin D mainly lowers the “adaptive” immune system.

• Inhibits B cell proliferation. (R)
• Inhibits immunoglobulin (Ig) secretion. (R)
• Inhibits T cell proliferation. (R)
• Shift from Th1 to Th2. (R, R2)
• Inhibits Th17. (R)
• Increases Tregs and IL-10. (R)
• Decreases inflammatory cytokines (IL-1, IL-6, IL-8, IL-12, TNFα, IL-17, IL-21). (R)
• Decreases TGF-beta (R)
• Decreases expression of MHCII and co-stimulatory molecules, which inhibits Dendritic Cell differentiation and maturation. (R)"

 

[bridgeburn]

https://selfhacked.com/2016/01/13/n...itrol-and-vitamin-d-receptor-gene-expression/

It seems to match with everything that is said recently about inflammations and Tregs etc...

"Vitamin D mainly lowers the “adaptive” immune system.

• Inhibits B cell proliferation. (R)
• Inhibits immunoglobulin (Ig) secretion. (R)
• Inhibits T cell proliferation. (R)
• Shift from Th1 to Th2. (R, R2)
• Inhibits Th17. (R)
• Increases Tregs and IL-10. (R)
• Decreases inflammatory cytokines (IL-1, IL-6, IL-8, IL-12, TNFα, IL-17, IL-21). (R)
• Decreases TGF-beta (R)
• Decreases expression of MHCII and co-stimulatory molecules, which inhibits Dendritic Cell differentiation and maturation. (R)"

it also decreases TGFb. testosterone increases tgfb which promotes catagen.

 

[jphalo]

And is that good ? I think we want to increase anagen and avoid telogen right ?

 

[bridgeburn]

And is that good ? I think we want to increase anagen and avoid telogen right ?

yes that is good, early catagen = less anagen. Tgfb isnt good for balding people.

 

[jphalo]

https://baldingblog.com/2015/08/31/can-calcipotriol-or-vitamin-d-analog-stimulate-hair-growth/

Is it easy to fake psoriasis in order to obtain Dovonex ? Because it seems to really work

 

[Medina]

https://baldingblog.com/2015/08/31/can-calcipotriol-or-vitamin-d-analog-stimulate-hair-growth/

Is it easy to fake psoriasis in order to obtain Dovonex ? Because it seems to really work

I have psoriasis. I use Dovobet (UK) on my elbows, it contains betamethasone and calcipotriol. Not sure it would do much for m.p.b

The study claims calcipotriol has no effect on hair whatsoever
https://www.ncbi.nlm.nih.gov/pubmed/8615060

 

[Jk1]

6 weeks is not enough time to see regrowth normaly 4 to 6 months is when we see regrowth. On scalp massage hairloss study 3 months was less than baseline and 6 months more. But good that calcioptrol doesnt cause shock loss ! I wounder how much better calciptrol is than topical cod liver oil ? Also we need some way to measure vit d levels at home or in the scalp. And vit d receptor expression as well would be great ! Then we can fine tune sun exposure...

 

[bridgeburn]

I have psoriasis. I use Dovobet (UK) on my elbows, it contains betamethasone and calcipotriol. Not sure it would do much for m.p.b

The study claims calcipotriol has no effect on hair whatsoever
https://www.ncbi.nlm.nih.gov/pubmed/8615060

that's sad to hear.. however In that study it says, "Topical treatment of scalp psoriasis (with corticosteroids, dithranol or tar)" so i'm wondering if calcipotriol wasn't the only ingrediant.. according to this which was posted here a couple of times Cortisol/Glucocorticoids decreases VDR production. -> https://selfhacked.com/2016/01/13/n...itrol-and-vitamin-d-receptor-gene-expression/

Wikipedia says that Glucocorticoids are a class of corticosteroids.

Also wondering do you use Dovobet in combination with antiandrogens or 5 Alpha inhibitors? cause maybe DHT which downregulates VDR counteracts its affect

 

[bridgeburn]

6 weeks is not enough time to see regrowth normaly 4 to 6 months is when we see regrowth. On scalp massage hairloss study 3 months was less than baseline and 6 months more. But good that calcioptrol doesnt cause shock loss ! I wounder how much better calciptrol is than topical cod liver oil ? Also we need some way to measure vit d levels at home or in the scalp. And vit d receptor expression as well would be great ! Then we can fine tune sun exposure...

There's a scalp massage study?

 

[resu]

http://shop.owndoc.com/product-info.php?infadolan-pid177.html

Why Infadolan is the best choice for dermarolling after care: Infadolan contains vit. A in non-acid form (0.1% Retinyl Acetate) that doesn't irritate the skin when the skin is "open". Infadolan is indicated for the treatment of first degree burns. Vitamin D2 (Ergocalciferol) has been shown to be a potent agonist of the vit. D receptor which stimulates glycosaminoglycan synthesis and transforming growth factor TGF-beta 1, thereby accelerating wound healing. Vit. D2 promotes dermal strength and re-epithelialization as well as enhancing granulation tissue formation. Infadolan contains natural Lanolin - an excellent occlusive. Occluding scars and stretchmarks after rolling postpones peeling and has a beneficial effect on healing. Infadolan is not a cream - it's an occluding ointment and you should only use a very thin layer. Lanolin helps the vit. D enter the skin. Lanolin allergy likely does not exist.

There you go.

 

[Jk1]

http://shop.owndoc.com/product-info.php?infadolan-pid177.html



There you go.

Infadolan plua dermaroller look like a great combo to add !

 

[Jk1]

Ye

There's a scalp massage study?

s here ! https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740347/

Ive been using it for 3 months now and love it ! But im exactly at 3 month point so i may have lost some terminal hair... gained some small ones i think... seems to have an exfoliation effect and also makes my hair look better by spreading scalp oils around !

 

[Jk1]

Scalp massage does no increase growth rate just density and thickness. I wounder if combining with some leds to get llt to help growth rate is a good combination to add to my massager!

 

[bridgeburn]

http://shop.owndoc.com/product-info.php?infadolan-pid177.html

Why Infadolan is the best choice for dermarolling after care: Infadolan contains vit. A in non-acid form (0.1% Retinyl Acetate) that doesn't irritate the skin when the skin is "open". Infadolan is indicated for the treatment of first degree burns. Vitamin D2 (Ergocalciferol) has been shown to be a potent agonist of the vit. D receptor which stimulates glycosaminoglycan synthesis and transforming growth factor TGF-beta 1, thereby accelerating wound healing. Vit. D2 promotes dermal strength and re-epithelialization as well as enhancing granulation tissue formation. Infadolan contains natural Lanolin - an excellent occlusive. Occluding scars and stretchmarks after rolling postpones peeling and has a beneficial effect on healing. Infadolan is not a cream - it's an occluding ointment and you should only use a very thin layer. Lanolin helps the vit. D enter the skin. Lanolin allergy likely does not exist.

There you go.

TGFb-1?!! earlier I mentioned that testosterone increases TGFb, however I checked my sources and maybe I was mistaken at the specifics of the number, Test seems to increase TGFb-2, "Caffeine counteracted testosterone-enhanced TGF-β2 protein expression in male HFs" https://www.ncbi.nlm.nih.gov/pubmed/24836650

This study says Minoxidil "inhibits of TGF beta induced apoptosis of hair matrix cells by opening the Kir 6.0 channel pore coupled with SUR on the mitochondrial inner membrane" https://www.ncbi.nlm.nih.gov/pubmed/11915519?dopt=AbstractPlus
But it didn't specify number??

Pretty much everything I've ever read online says that TGF beta puts hair in catagen phase... So now I'm confused if VDR, stimulates TGFb1 or what the differences between TGFb1 and TGFb2 is?? I don't know, somebody help me

 

[bridgeburn]

There was also that other thing which said VDR decreases TGF beta, but which number?? f***, maybe it doesn't even do that?

 

[jphalo]

I understand "transforming growth factor TGF-beta 1" as a decrease because it is transformed in something else but this sentence is confusing

 

[bridgeburn]

I understand "transforming growth factor TGF-beta 1" as a decrease because it is transformed in something else but this sentence is confusing

oohhhhh, yeah that must be it! VDR may use it to heal skin and leaves hair alone , VDR must definitely be beneficial

 

[resu]

TGFb-1?!! earlier I mentioned that testosterone increases TGFb, however I checked my sources and maybe I was mistaken at the specifics of the number, Test seems to increase TGFb-2, "Caffeine counteracted testosterone-enhanced TGF-β2 protein expression in male HFs" https://www.ncbi.nlm.nih.gov/pubmed/24836650

This study says Minoxidil "inhibits of TGF beta induced apoptosis of hair matrix cells by opening the Kir 6.0 channel pore coupled with SUR on the mitochondrial inner membrane" https://www.ncbi.nlm.nih.gov/pubmed/11915519?dopt=AbstractPlus
But it didn't specify number??

Pretty much everything I've ever read online says that TGF beta puts hair in catagen phase... So now I'm confused if VDR, stimulates TGFb1 or what the differences between TGFb1 and TGFb2 is?? I don't know, somebody help me

They expand their choice in their forum:

Infadolan is a medical grade, regenerative, protective ointment with vitamins A+D and Lanolin.

There are several reasons why we chose INFADOLAN. First of all some other A+D ointments contain Zinc oxide, which is a mild astringent. An astringent is a chemical substance that shrinks and constricts body tissues. Zinc oxide acts as a skin-drying agent and can act as a skin anti-inflammatory. Astringents cause mild coagulation of skin proteins and that causes the skin to dry up.



Zinc's "drying" properties are very beneficial in treating diaper rash, oily skin with acne or any other skin condition where drying the skin is desirable. Zinc oxide is also an excellent sun protection because it reflects the UV rays.



After dermarolling though, the "open" skin should be kept as moisturized as possible and that's why substances with astringent and dessicating (drying) properties are not suitable.

http://forums.owndoc.com/dermarolling-microneedling/questions-about-your-vit-a-d-ointment-infadolan/