Lol this has been discussed before this guy was taking a JAK orally and not topically. Christiano said that topical would be the only way cause a higher amount of JAK would need to hit the hair follicle in Androgenetic Alopecia
Hair follicles
are highly specialized organelles that are in a perpetual state of
growth and regeneration. In addition to Tregs, a major epithelial
stem cell (SC) population localizes to HFs (HFSCs) (Blanpain and
Fuchs, 2009). These cells play an indispensable role in HF regeneration
and repair of the epidermal barrier after injury (Ito et al.,
2005). Interestingly, several studies link Tregs with HF biology.
Genome-wide association studies in alopecia areata (AA), a disorder
of HF regeneration, have revealed single nucleotide polymorphisms
in genes involved in the differentiation and function
of Tregs, including interleukin (IL)-2, the high-affinity IL-2 receptor
alpha (CD25), CTLA-4, Eos (IKZF4), and Foxp3 (Petukhova
et al., 2010). In addition, pharmacologic augmentation of Tregs
in humans with low-dose IL-2 was highly efficacious in treating
AA (Castela et al., 2014). Despite these associations, a functional
link between Tregs and HFs has yet to be established.
Jaks won't be usefull for us
I kinda got the feeling lately that we got to a point in understanding the human body (and hairloss mechanism) where development has slowed down. It seems like the body is a vastly complex ecosystem where everything is connected with everything.
In my understanding the way science is conducted is focusing on some small thing (like a gene or a receptor or something) and messing with it possibly with every other stuff unchanged (ceteris paribus) and looking at the outcome.
It's like if a software engineer would look at a huge *** software code and changed/deleted a small part of it and recorded the outcome. Maybe it would cause nothing visible, maybe something, maybe it would only have an effect if some other variable changed as well. But it would be a painfully slow process to try to understand the whole code with this method.
Maybe what I'm trying to say is scientists need to adapt a more holistic view, or take lessons in system design or software engineering or something. Anyway it's just my layman opinion.
Cope
Just considering their method of action alone, it's ridiculous to put any sort of stock in JAK doing anything for Androgenetic Alopecia no matter how it's delivered.
I'm just tired to read every half a year a new study where scientist "find" the cause of hairloss by identifying 1 protein or 1 gene or 1 something . Which translates to nothing in real life. Hairloss is obviously a multifactoral disease and looking at 1 piece at a time of the whole puzzle might lead to missing the big picture.
Hey there again long time no see I have a question what is your preferred definition when you mention "effective solution"?Robert Hoffman of Anticancer Inc said something similar. He thinks the solution to male pattern baldness might not have to be perfect so long as jt works. I think understandinG the genetics of male pattern baldness will lead to an imperfect but effective solution. And because HF are now viewed as the easiest to access miniature organs, the cheapest fix will eventually be a cheap, OTC topical cream or ointment.
Hey there again long time no see I have a question what is your preferred definition when you mention "effective solution"?
So I'll spray or rub in/apply a topical substance "solution" and it will supposedly even if im slick nw7 give me back my hair thick enough where the male pattern baldness pattern is unrecognizable correct?Something that will grow hair in cosmetically significant amounts.
In addition to this oral formulation of the JAK 1/3 inhibitor, Aclaris also plans to develop a topical formulation, known as ATI-50002, for the treatment of AA, vitiligo, and androgenetic alopecia (Androgenetic Alopecia). Specifically, Aclaris plans to: ...
I wish there were shortcuts in science, but there aren't.
Jaks won't be usefull for us
There are. Just test on humans instead of mice.
It's more complicated than whipping up a batch of cream and testing on humans without medical sanction. Things are different when one has "skin in the game" so to speak.