New Dermaroller Study; Thoughts, comments?

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Jlyncher

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I noticed an increase in shedding early on, weeks 4-8 or something like that. I leveled out around 10 weeks, just a couple hairs in the shower.

What week are you on Karankaran? How much shedding?
 

opti

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any1 knows something to increase lipogenesis /adipogenesis?Since i think subcutanous fat may be very very helpfull in hair regrowth.

many bald ppl have less subcutanous fat which comes from fat cells which split up to fat acids ,which leads to inflammatory .Also hardened collagen laying above the fat cells disturbs the blod flow to the follices.-> hair loss

In hair transplant the injected hair are maybe more getting mroe deep into the hypodermis then the bald ones,which maybe stuck at the hardened collagen and dont get much blood to grow.


http://www.stemcellrevolution.com/currently-studying/hair-restoration/hair-restoration/

Horsley’s team observed that when hair dies, the layer of fat in the scalp that comprises most of the skin’s thickness shrinks. When hair growth begins, the fat layer expands in a process called adipogenesis. Researchers found that a type of stem cell involved in creation of new fat cells — adipose precursor cells — was required for hair regeneration in mice.

also fat cells are the ones to signal the hair to get terminal.



http://www.dailymail.co.uk/health/a...dy-years-using-fat-cells-sagging-bellies.html

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[h=1]Retinoic acid upregulates preadipocyte genes to block adipogenesis and suppress diet-induced obesity.[/h]

http://www.ncbi.nlm.nih.gov/pubmed/22396202

The data also indicate that RA(Retinoic acid) suppresses adipogenesis in vivo and that the activity significantly contributes to the ability of the hormone to counteract diet-induced obesity.
 
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HairShocka

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DesperateOne. Miconazole Nitrate is a medical ointment that has absolutely no smell to it.. Stop misinforming people dumbass. you ****ing smell. Also, I bet you never had a pussy of your life, my little chronic masturbator.

Gotcha. Do you use Miconazole Nitrate cream? Keto Shampoo? both? or none? while rolling.

I keep hearing Keto Shampoo is too harsh for the hair to use daily. I use it almost 4 times a week and rub spironolactone on days I don't use the Keto. I want to use something daily, so if if the vadgecream isn't too harsh and doesn't stink then I might try it out when I begin to roll.
 

Irishjim

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Week 5 and I'm shedding like never before. I've been on minoxidil and finasteride for a year now and have never shed like this... I hope it's worth it. I am seeing some new Venus hair so something is happening.
 

albert

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Week 5 and I'm shedding like never before. I've been on minoxidil and finasteride for a year now and have never shed like this... I hope it's worth it. I am seeing some new Venus hair so something is happening.

Welcome to the club!
 
K

karankaran

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Guys, hopefully in 6 months we see a lot of pics like the ones in Indian study, and then i will start my experiment...btw i hope that the regrowth is not just for the hairs that shed during rolling ,, but for the news ones.... btw i still have hair in my bald area like usually my hair is extremely dense other than the bald patch , so even in the bald area there is hair but since density is so less...my scalp is visible... have you guys felt having your existing hairs tangled during rolling?
 

Kirby

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Week 5 and I'm shedding like never before. I've been on minoxidil and finasteride for a year now and have never shed like this... I hope it's worth it. I am seeing some new Venus hair so something is happening.
Wow, I'm doomed in 3 weeks time then if that's a guide to what to expect, LOL. Interesting that 1. you're shedding earlier than the 7-9 week mark other users have reported, 2. 5ARi users are getting sheds from a minoxidil based treatment plan.
 

boldmun

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I don't post often but actively read this forum and I don't understand most of the science posted here, but I have been keeping up with this thread since the start. I have been onFinasteride for 2 years and minoxidil for 6 months and continue to lose my hair. This thread has been helpful in giving me hope. I am glad that a lot of other people are trying it and posting their results.

With this treatment, I am on my 7th week and I don't see anything happening yet. Maybe if I had a microscope, but overall my hair has not changed. The only thing is that after every "session" I have a bunch of red clots on my head and a ton of dandruff.

It reminds me of a time when I read this research on another forum about removing a scar years ago. I had tried everything on my scar including retin A, 1.5 mm dermaroller, and TCA peel. You name it I tried it. This research study involved putting Lugol's iodine on the scar a couple times a day, staining the skin. The skin is supposed to regenerate. I was so sure the science was strong that I kept up with for a year. I burned through layers and layers of skin. Now I am left with an even worse scar that is still discolored. No, there is no big foot hair growing out of the area. Perhaps I needed to continue for longer, but I didn't get results.

However, with this I have nothing to lose since minoxidil doesn't burn the skin. I will keep trying for a year and update my results. Hopefully, this will work for those that are trying it.
 

squeegee

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Legitimate treatments will cause a change in the hair cycle which results in affected hairs being ejected to make room for new hairs. Thus you may see a temporary wave of increased loss. It's only an apparent increase in actual loss, however, as this falling hair had stopped its growth cycle many weeks earlier and was just waiting to drop out.
Increased fallout of this sort should normalize within a few weeks. If it continues over a prolonged period of time (a few months) it may be that the treatment is contraindicated. Note that some do not notice any increased shedding with various treatments. Increased shedding is most often a positive sign, but its absence is not a negative sign.
Note also that hair fallout is not perfectly uniform throughout the year, so sometimes increased or decreased shedding is simply coincidental with normal hair cycles. Also bear in mind that it is perfectly normal to lose over 100 hairs every day, even if you are not dealing with hair loss. The problem with pattern loss is primarily one of having insufficient regrowth. You can read more about shedding in our article:


Shedding is Normal

Believe it or not, shedding after starting a treatment is fairly common. In fact, more often than not, our users report increased loss a few weeks to a few months after starting Propecia or Rogaine (or both!). But what a shock it can be to those who don't expect it. They finally take that dive into the daily commitment of fighting their hair loss. They're finally ready to do something about it, and as hopeless as things may seem, they put all their trust in the clinical data. They have a few weeks of feeling a little better about things, hoping for the best, knowing they're doing all they can ... and then something goes wrong. They actually start to *lose* hair. At least that's how it looks. Instead of going forward, they're going backwards. The more level headed shedders decide to wait it out a few days, only to see it continue... and continue... and continue. The rest panic, or just throw in the towel entirely. They decide they are not "responders" to the treatment, that the treatment doesn't work, or quite simply that God has forsaken them. Fortunately, they're wrong on all three counts...

What exactly is Shedding?

sheddiag.gif

In all cases, treatments or no treatments, shedding is not actually "losing hair". This is one of the most common misconceptions in the world of hair loss. Shedding is in fact just the transition of follicles from growth phase to resting phase. They don't fall out and die, never to return. They in fact "go to sleep", to return several months later. Hair follicles work in cycles as part of their normal processes. Even the person not losing his or her hair goes through the same cycles. The hair will grow for awhile, and it will rest for awhile. In the case of someone *not* using any treatments, but experiencing Androgenetic Alopecia (Male or Female pattern baldness), shedding is typically the continued cyclical process, combined with miniaturization. What does this mean? It means each time those hairs go dormant and come back, they come back weaker, thinner, and less pigmented, ultimately resulting in the perception of less hair and more scalp skin showing. There are theories out there as to why hair seems to go "all at once" for those losing hair, but they are still just theories. The most common one is the theory that those with androgenetic alopecia see more of a synchronization of dormancy. Meaning - more hairs go dormant at the same time, ejecting the existing hair and shutting down temporarily. Either way, the moral of the story is the same: Shedding is not losing hair. Its dormancy. And it is up to you as to whether those hairs cycle back in thicker and stronger, or thinner and weaker. That's where using a DHT inhibiting, or growth stimulating treatment comes into play.

Shedding *because* of my Treatment?!?

Its possible, and as mentioned above, rather common. Surprised? Its actually the most common reason why people think hair loss treatments don't work! If you start a new treatment like Rogaine or Propecia, you probably will shed, but the amount of hair shed varies from person to person. It has long been suspected that there is an increase in shedding in the first 3 months or so. Recently, some studies using a digital phototrichogram (Trichoscan, Marburg, Germany) proved that there was indeed a quantifiable increase in shedding and a corresponding loss of hair density in the first 3 months of minoxidil use. However, by the 6 month stage the subjects were shown to have regrown the lost hair and had increased hair density compared to that recorded at the start of treatment. By 12 months after starting minoxidil use their hair density was much improved and the diameter of the hair fibers was thicker than at the start of treatment and as compared to controls who did not receive treatment. This small study proves what has long been suspected and frequently discussed on hair loss forums, that there is an initial shed phase when first starting minoxidil use.

How long will it last?

Shedding is temporary. If the individual continues their treatment consistently, despite the seeming despair and loss of hope, shedding will end and the lost hair should be replaced.

hy does it happen?

nirv.jpg

Although we do not know exactly why the shedding occurs, the most likely explanation is due to how the hair follicle "organ" operates. Hair follicles are relatively inflexible in their anagen, "hair producing" state. In response to additional stimuli the growing hairs may be able to increase their growth rate or increase the diameter of the hair fiber produced a little, but it is not possible for a hair follicle to undergo big changes in size while producing hair fiber. What ends up happening, is that when that follicle gets hit with a growth stimulant like Minoxidil, it is given a very strong signal to change size (expand) and increase activity. The rule of the follicle is that it must then stop, and start over. The existing hair is ejected, the follicle goes into dormancy, and begins to restructure its processes to produce a thicker, stronger hair that can produce a bigger (thicker) hair fiber.

Shedding is a sign that the Treatment is Working

Howso??? When Rogaine is applied to stimulate hair follicles, the follicles must regress, shed the old fiber, rearrange themselves into a bigger hair follicle, and start making a new, improved fiber. This would inevitably lead to a temporary shed phase. You're seeing your hairs respond. Its unfortunate that the first sign of new hair growth is seeming hair LOSS, but that's the way it works, quite often.

There is a belief among some dermatologists that an initial shed phase when first starting to use a treatment for hair loss is inevitable regardless of the treatment used. Because of the hair follicle's inflexibility in changing the nature of hair growth mid stream, for any drug to promote hair growth it must involve hair follicles entering telogen to rearrange themselves into a larger follicle under the influence of the drug. However, certainly, the shed phase with minoxidil use can be very apparent in some people.

But "BOB" on xxxx.com told me that the shedding will NEVER STOP!

There are a few who claim that using treatments like Propecia and Minoxidil can cause a persistent shedding that lasts longer than the first three months. While there is no hard research evidence to support these claims, it is always possible that an individual may have an adverse reaction to a drug. We are each unique because of our different genetic make up and the different environments in which we live. This means that there are somewhat different responses to the same drug when used by different people. It is almost inevitable that a very few people will have a bad reaction to a drug. It may be that for a few minoxidil does more harm than good and follicle growth cycles are adversely affected. If this is the case, stopping use of the drug should allow the body to recover. However, it is most likely that many of the claims for persistent shedding actually come from those who are experiencing the expected shedding in the first 3 months, have not been consistent with their dosages, or have been continually adding or taking away from their treatment regimen.

But *I* think I have Telogen Effluvium!

womanshed.gif

Many hair loss sufferers with traditional male or female pattern baldness want to believe they have Telogen Effluvium (Telogen Effluvium), because it provides a glimmer of hope that the whole ordeal is just temporary. Unfortunately, Telogen Effluvium by definition is a condition that occurs in response to serious traumatic shock to the system as a whole. It is not a something that will happen without any abnormalities going on in your life. Things like sudden shock, chronic debilitating stress, extreme malnutrition, certain medications, and chronic serious illness are the most common causes. There is no way to know for sure how long shedding will last with telogen effluvium. Increased shedding occurs in response to a trigger factor. If exposure to the trigger is brief and there are no other contributing factors then the shedding may last for around 3 months and then recover so that 6 months later the hair is pretty much back to normal. However, if the trigger factor hangs around, like chronic stress or illness, then the shedding may persist. The hair follicles can get into a habit of short, truncated growth cycles, producing short hair that falls out after a few months. This results in a high shed rate - although the hair loss on the scalp need not progress much.

In Conclusion - Don't Count Hairs

In terms of understanding hair loss, the nature of shed hair and the rate of shedding is not very important, although it may be disturbing to see. Shedding is natural, everyone sheds hair daily whether affected by hair loss or not. You can shed up to 100 scalp hairs a day without having any scalp hair loss. A few people may shed more than this but still not develop baldness. To understand the development of hair loss the main factor to consider is the rate of hair growth and replacement, not so much the rate of shedding. Some people have a high rate of shedding but also a high rate of hair growth. The result is no net loss of hair on the scalp. Some people have a low rate of hair shedding and a low hair regrowth rate. The result is similarly no alopecia development. The problem comes when someone sheds hair at a faster rate than it is replaced. This is the scenario where baldness develops. You can have a normal or even a low shed rate and still develop baldness. If the hair is being shed faster than it regrows then alopecia will develop. So the amount hair shed each day/week/month is a poor diagnostic indicator of hair loss. To define alopecia you must look at what is left on the scalp. That is where it counts.

http://www.hairlosstalk.com/hair-loss-news/Article223.php

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Gotcha. Do you use Miconazole Nitrate cream? Keto Shampoo? both? or none? while rolling.

I keep hearing Keto Shampoo is too harsh for the hair to use daily. I use it almost 4 times a week and rub spironolactone on days I don't use the Keto. I want to use something daily, so if if the vadgecream isn't too harsh and doesn't stink then I might try it out when I begin to roll.

Get the 4% one. 2% is useless. Keto is harsh on the hair. Mico is not and have nitrate in it which boost hair growth speed.
 

DesperateOne

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Wow, I'm doomed in 3 weeks time then if that's a guide to what to expect, LOL. Interesting that 1. you're shedding earlier than the 7-9 week mark other users have reported, 2. 5ARi users are getting sheds from a minoxidil based treatment plan.

lol yeah, get ready for it, it will come hard for you. It can be very demoralising, but shedding is typically a good thing.
 

cthulhu2.0

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things have definitely been improving for me recently, I am not sure if its just the dermarolling or the vitamin B12/alcohol/water mixture that I have been applying several hours after minoxidil for the past week. It may be hard to see from the pics but I feel I have been gaining a lot of ground with the two. btw 10 weeks in.

Old pics:pic1 13-53-45.jpgpic2.jpg

new pics:
333.jpg444.jpg
 

squeegee

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things have definitely been improving for me recently, I am not sure if its just the dermarolling or the vitamin B12/alcohol/water mixture that I have been applying several hours after minoxidil for the past week. It may be hard to see from the pics but I feel I have been gaining a lot of ground with the two. btw 10 weeks in.

Old pics:View attachment 21898View attachment 21899

new pics:
View attachment 21900View attachment 21901

good frigging stuff! Keep on rollin..........:punk:
 

Jlyncher

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Jlyncher how has rolling treated you?

Hey Donc, I'm happy with my results so far. Very happy in fact. I've kept it simple; 192 ct, 1.5mm, rinsed with rubbing alcohol before and after use, rolling once weekly after a hot shower and a shot of premium liquor:beer:. No issues at all in that regard.

First several weeks I saw little, if any blood. Now, my head is covered with blood spots by the end of the session. I think this is a combination of increased blood supply, and becoming more aggressive(fully inserting) with the dermaroller. Typically it takes me 15-20 minutes to cover my whole head from every direction with 5 rolls per row.

It hurts...but it's not excruciating. About halfway through my head goes mostly numb anyway.

It works. To what degree I don't know, but I intend to find out. I'm seeing a definite increase in terminals around the hairline, and I assume all over. Also, I have some miniaturized, but pigmented hairs popping up well below my hairline, where there has been nothing but scalp for many years. Maybe nothing will come from them but I'm very optimistic at this point, as I've been on finasteride and min for years and never saw any hair in that area. I just did my 13'th roll, I'll be doing 3 more months minimum.




things have definitely been improving for me recently, I am not sure if its just the dermarolling or the vitamin B12/alcohol/water mixture that I have been applying several hours after minoxidil for the past week. It may be hard to see from the pics but I feel I have been gaining a lot of ground with the two. btw 10 weeks in.

Old pics:View attachment 21898View attachment 21899

new pics:
View attachment 21900View attachment 21901

Nice!
 

Jaded

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I just switched from a 540 to a 192 dermaroller. It hurts more but it didn't remove half my hair in the process. I was going to roll every two weeks, but now i'm going to do weakly with a small session instead of being thorough . Seing how much hair i lost with the 540 dermaroller i don't think it makes sense keep injuring weekly the same spot, if something good is happening there, let it be.

If anybody have scientific data that meat grind your scalp is the way to go please share it.
 

albert

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Hello. I took recent photos of my right temple. I saw some hairs that turned terminal, or that is what I think. They look way much shorter than the rest of my hair, and they look pigmented. On my left temple there is also few like that that, but it's more impressive on this other side. Also, I'm including a pic of my forehead, where I had previous vellus hairs starting to pigment, and now they look okay. What do you think?

Edit: Just shaved the areas where the pics were taken for the first time, so I can easily track future growth of new hairs (if any).

Right temple (the three pics are the same place, just different angles)

ybST7ks.jpg





dwSBojk.jpg


dJxiNbz.jpg


Forehead

SCZu89x.jpg
 

closetmetrosexual

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things have definitely been improving for me recently, I am not sure if its just the dermarolling or the vitamin B12/alcohol/water mixture that I have been applying several hours after minoxidil for the past week.

Where did you get your B12? What kind is it?
 
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