My succes story: Big 2 + piroctone olamine (UPDATE 10/06/10)
- Thread starter eXVee
- Start date
Bumping this one. Anyone using shampoo with Piroctone Olamine with success?
Looks like an excellent combination with Nizoral. According to the study below it might be even more effective. I am considering starting with this one on non-Nizoral days.
Int J Cosmet Sci. 2002 Oct;24(5):249-56. doi: 10.1046/j.1467-2494.2002.00145.x.
Nudging hair shedding by antidandruff shampoos. A comparison of 1% ketoconazole, 1% piroctone olamine and 1% zinc pyrithione formulations.
Piérard-Franchimont C1, Goffin V, Henry F, Uhoda I, Braham C, Piérard GE.
Abstract
Hair shedding and hair thinning have been reported to be affected by dandruff and seborrhoeic dermatitis. The present study was conducted in 150 men presenting with telogen effluvium related to androgenic alopecia associated with dandruff. They were randomly allocated to three groups receiving each one of the three shampoos in the market containing either 1% ketoconazole (KTZ), 1% piroctone olamine (PTO) or 1% zinc pyrithione (ZPT). Shampoos had to be used 2-3 times a week for 6 months. Hair shedding during shampoo was evaluated semiquantitatively. Hair density on the vertex was evaluated on photographs using a Dermaphot. Trichograms were used for determining the anagen hair percentage and the mean proximal hair shaft diameter using computerized image analysis. The sebum excretion rate (SER, mug cm(-2) h(-1)) was also measured using a Sebumeter. The three treatments cleared pruritus and dandruff rapidly. At end point, hair density was unchanged, although hair shedding was decreased (KTZ: -17.3%, PTO: -16.5%, ZPT: -10.1%) and the anagen hair percentage was increased (KTZ: 4.9%, PTO: 7.9%, ZPT: 6.8%). The effect on the mean hair shaft diameter was contrasted between the three groups of volunteers (KTZ: 5.4%, PTO: 7.7%, ZPT: -2.2%). In conclusion, telogen effluvium was controlled by KTZ, PTO and ZPT shampoos at 1% concentration. In addition, KTZ and PTO increased the mean hair shaft thickness while discretely decreasing the sebum output at the skin surface.
Looks like an excellent combination with Nizoral. According to the study below it might be even more effective. I am considering starting with this one on non-Nizoral days.
Int J Cosmet Sci. 2002 Oct;24(5):249-56. doi: 10.1046/j.1467-2494.2002.00145.x.
Nudging hair shedding by antidandruff shampoos. A comparison of 1% ketoconazole, 1% piroctone olamine and 1% zinc pyrithione formulations.
Piérard-Franchimont C1, Goffin V, Henry F, Uhoda I, Braham C, Piérard GE.
Abstract
Hair shedding and hair thinning have been reported to be affected by dandruff and seborrhoeic dermatitis. The present study was conducted in 150 men presenting with telogen effluvium related to androgenic alopecia associated with dandruff. They were randomly allocated to three groups receiving each one of the three shampoos in the market containing either 1% ketoconazole (KTZ), 1% piroctone olamine (PTO) or 1% zinc pyrithione (ZPT). Shampoos had to be used 2-3 times a week for 6 months. Hair shedding during shampoo was evaluated semiquantitatively. Hair density on the vertex was evaluated on photographs using a Dermaphot. Trichograms were used for determining the anagen hair percentage and the mean proximal hair shaft diameter using computerized image analysis. The sebum excretion rate (SER, mug cm(-2) h(-1)) was also measured using a Sebumeter. The three treatments cleared pruritus and dandruff rapidly. At end point, hair density was unchanged, although hair shedding was decreased (KTZ: -17.3%, PTO: -16.5%, ZPT: -10.1%) and the anagen hair percentage was increased (KTZ: 4.9%, PTO: 7.9%, ZPT: 6.8%). The effect on the mean hair shaft diameter was contrasted between the three groups of volunteers (KTZ: 5.4%, PTO: 7.7%, ZPT: -2.2%). In conclusion, telogen effluvium was controlled by KTZ, PTO and ZPT shampoos at 1% concentration. In addition, KTZ and PTO increased the mean hair shaft thickness while discretely decreasing the sebum output at the skin surface.
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I have. PO is probably the 2nd best thing to Keto, and there's even a study showing they have synergy when used together(unlike Zinc P).
Unfortunately, it's very difficult to find shampoos with PO. I literally couldn't even find an American one anymore in 2017. So I bought one from India and another from Germany(this one smelled horrible and was literally pure liquid like water).
Anyway, I got sick of dealing with that, and just bough Piroctone Olamine powder, which I dumped in some 95% ethyl alcohol alongside ketoconazle powder both at 2%. I use it once every 4 days. I also have a version with RU58841 in the mix.
Apparently PO is considered effective to treat hair loss as low as 0.5% but has been tested at up to 8% with unpublished results.
I found this handy spec chart that details things like how to dissolve it in various alcohols, soaps, oils, etc. It also includes several studies I haven't seen published elsewhere.
https://www.in-cosmetics.com/__novadocuments/2882
Apparently it's even topically effective for killing malassezia yeast, which is interesting, because I was only aware of oral ketoconazle to treat that effectively.