My succes story: Big 2 + piroctone olamine (UPDATE 10/06/10) | Page 2 | HairLossTalk Forums

My succes story: Big 2 + piroctone olamine (UPDATE 10/06/10)

Discussion in 'Success Stories' started by eXVee, May 18, 2010.

  1. eXVee

    eXVee Established Member

    Joined:
    Aug 4, 2008
    Messages:
    163
    Likes Received:
    3
    Dislikes Received:
    0
    @ Obsidian

    I didn't say their hasn't been any talk at all, I said not much. If you compare the amount of threads about PO with those about ketoconazole you'll come to the same conclusion. :)
     
  2. Silber

    Joined:
    Mar 7, 2017
    Messages:
    21
    Likes Received:
    17
    Dislikes Received:
    3
    My Regimen:
    My Regimen
    My Regimen
    Bumping this one. Anyone using shampoo with Piroctone Olamine with success?

    Looks like an excellent combination with Nizoral. According to the study below it might be even more effective. I am considering starting with this one on non-Nizoral days.

    Int J Cosmet Sci. 2002 Oct;24(5):249-56. doi: 10.1046/j.1467-2494.2002.00145.x.
    Nudging hair shedding by antidandruff shampoos. A comparison of 1% ketoconazole, 1% piroctone olamine and 1% zinc pyrithione formulations.
    Piérard-Franchimont C1, Goffin V, Henry F, Uhoda I, Braham C, Piérard GE.

    Abstract
    Hair shedding and hair thinning have been reported to be affected by dandruff and seborrhoeic dermatitis. The present study was conducted in 150 men presenting with telogen effluvium related to androgenic alopecia associated with dandruff. They were randomly allocated to three groups receiving each one of the three shampoos in the market containing either 1% ketoconazole (KTZ), 1% piroctone olamine (PTO) or 1% zinc pyrithione (ZPT). Shampoos had to be used 2-3 times a week for 6 months. Hair shedding during shampoo was evaluated semiquantitatively. Hair density on the vertex was evaluated on photographs using a Dermaphot. Trichograms were used for determining the anagen hair percentage and the mean proximal hair shaft diameter using computerized image analysis. The sebum excretion rate (SER, mug cm(-2) h(-1)) was also measured using a Sebumeter. The three treatments cleared pruritus and dandruff rapidly. At end point, hair density was unchanged, although hair shedding was decreased (KTZ: -17.3%, PTO: -16.5%, ZPT: -10.1%) and the anagen hair percentage was increased (KTZ: 4.9%, PTO: 7.9%, ZPT: 6.8%). The effect on the mean hair shaft diameter was contrasted between the three groups of volunteers (KTZ: 5.4%, PTO: 7.7%, ZPT: -2.2%). In conclusion, telogen effluvium was controlled by KTZ, PTO and ZPT shampoos at 1% concentration. In addition, KTZ and PTO increased the mean hair shaft thickness while discretely decreasing the sebum output at the skin surface.
     

Share This Page