- What advancements have been made since that study?
We developed a novel hair regeneration using a bioengineered hair follicle germ transplantation. Our method have several advancements such as the control of eruption hair density and hair color, compared to previous studies.
- While success was shown in the rodent model, how do you predict such a bioengineered hair follicle germ will behave when injected into the scalp of a human?
I think that our treatment will succeed in human as well as rodent model. We will isolate the cells from the back of head of scalp patients and then transplant into scalp area. The bioengineered hair follicle will be erupt in the area and the hair is same to that in the back of head.
- Before we can be successful we will also need to be able to mass produce these bioengineered hair follicle germs, right? Based on current advancements it seems to be difficult to culture DPC, because they lose their signature in vitro. How do such problems apply to the current method described in the study?
As you pointed, the problem of our project is the expansion of stem cells in the bulge region and dermal papillae. In these problems, the expansion of epithelial bulge stem cells is critical issue. Thus, we are now trying to expand the stem cells.
- When can we expect that such a method will find their way to testing (clinical trials) in humans? How close are we?
We would like to realize human clinical study at 2020. We will overcome the several hurdles and realize human clinical study within 5 years.