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@Wolf Pack @Roberto_72 : Could he post some pics in the near future ? Thanks
It's a post from @BaldyBalderBald,
As he can't yet post some pics, I post for him the following Text
" Hi everyone,
First post here, just finally sign-up after few years lurking here for new upcoming treatments to get rid of fina after 13 years regimen of 1mg/d.
Started balding at 15....yeah 15 f*****g years, tried minoxidil until 18, then switched over fina cause minoxidil fucked up my scalp bad, managed to maintain Norwood 1.5 13 years but this f*****g disease finally seems to catch up with me...aaaanyways...been doin' some research on follicular neogenesis and i got some food for thoughts for you.
Creating some new hair follicles seems fine, but in order to achieve an acceptable cosmetic and natural look, it needs multiple criterias
1. Density, obviously
2. Thickening
3. Direction
I don't know if density and thickening results will be good, Follica and Dr. Cots seems to be ellusive on this part.
Third one seems to be the problem here, in all patents or discussions i've read about de novo HFs...well direction is not controlled by any means and to me this is the major issue of this technique, especially for hairline, no one wants a frontal hairline or hair randomly grow in every god damn directions, and most major Norwood 0 hairlines have a very specific direction pattern, like Christian Bale one for example :
View attachment 64575
f****r got a solid one.
Anyway the only sources i've find talking about this quote that de novo HFs directions are quite random and organised in clusters...in mice whatever.
View attachment 64576
"Distribution and orientation of neogenic hairs in regenerated wounds. (A) Commonly, regenerated HFs form one large cluster (also see Fig. 3). One or a few small secondary cluster(s) can also be present. (B) Seldom, multiple small de novo HF clusters can form (eight clusters here). (C), (D) Orientation of de novo HFs can range from seemingly random (D, purple region; also see Fig. 3) to unidirectional. Commonly, the neogenesis zone can contain several sub-clusters of HFs with distinct orientation (C). Hairs have similar direction within a sub-cluster, but often opposite of that in the neighboring sub-cluster (white vs. black in C and D). Here, WNT pathway reporter BAT-gal (A−C) and BRE-gal reporters (D) were used to aid visualization of neogenic hairs as strongly lacZ-positive. Size bar 1 mm."
Full paper here : http://onlinelibrary.wiley.com/doi/10.1002/reg2.38/full
Dr. Bernstein mention it too in an article talking about follicular neogenesis and hair cloning, quoting
"Another problem of hair cloning is that the orientation of hair direction must be controlled. With mouse experiments, the hairs grow at all different directions. Scientists need to find a way to align the hair so that it grows in the right direction. Hair, of course, must also be of a quality that is cosmetically acceptable and matches the patient existing hair. And the hair should grow in follicular units. Individual hairs will not give the fullness or natural look of follicular units."
Source : https://www.bernsteinmedical.com/medical-treatment/hair-cloning/answers/
Some photos of neogenesis or not quite good like this one, and you can see the direction randomness :
View attachment 64577
Noticed "graft" being mentionned, result of cultured DPCs cells being transplanted, same result as new formed DPCs cells.
@hellouser , if you're reading this, this got to be the first and major question for Follica's team at the next Hair Congress, but I already assume Dr. Cots will elude this again.
As for the DHT sensitivity of de novo HFs, I remember reading that they won't be but i can't find the source anymore, i'll keep searching, all I found is about PGD2 and seems to indicate the opposite actually, but i'll definetly retrieve the source where i've read they won't be sensitive, being basically "out of system" follicles.
Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis through the Receptor, Gpr44
http://www.sciencedirect.com/science/article/pii/S0022202X15361753 "
Just to be sure, the question should be
'Does Follica's method of wound induced follicle neogenesis take into consideration the direction of the new follicle and hair fibre that grows or will it take on the pattern of the previous hair before the balding state?'
If this is sufficient, I'll add this to my list as the first question. Perhaps Dr. Washenik could shed some light if not Dr. Cotsarelis.