Yeah if you have the dough, time and inclination why not. But for many people trying a false or poor remedy might be likely to put them off the meds that really work. The other thing is the absolutism about, "oh, I wont try that one because" negates the scientific reality of titration of strength. There are many permutations as to how to use oral min. The standard for females is below 2.5mg daily but combined with 25mg of spironolactone, also daily. This is such a small amount of oral min that it's difficult to measure without the actual Loniten pills but drinking literally one drop a day of topical min can make a huge difference for some.
The people who refuse to use minoxidil because it's bad for their skin, just crack me up. Unless they have a perfect mug, who the crap cares about circles under the eyes when they are bald. Nobody is looking at anything except for that chrome dome. There are also many treatments for skin but as mentioned, very few that are likely to work outside the big 3.
Melatonin was a really big deal in the '90's and it was alleged to cure many/most things. In actuality, it mostly made people drowsy. But since forever, people trot out melatonin as supposedly having all of this value for health but it's difficult to find them when actually using them. I took melatonin for years but I don't think it affected hair one way or the other.