If Hairloss Is All About Dht Level...
- Thread starter NiBBa
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Because sensitivity to DHT increases
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It is all about "speed " of miniaturisation. In most people DHT slowly miniaturize hair which is not apperant until they hit mid 30s. The balding process in all predisposed men starts when they hit puberty ,some become bald in early some later . but proceeds a starts when DHT surge after puberty.
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Do you know if childrens have DHT in scal hairs? The sebaceous gland is fully operative at 4/6 years, or less....
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Diffuse thinning definitely does start just right around puberty.
My male pattern baldness started when I was aprox 17-18yo, but I didn't pay much attention to this
https://imgur.com/a/PX1iy75
Now I'm 28yo with NW6 pattern
https://imgur.com/a/PX1iy75
Now I'm 28yo with NW6 pattern
Nobody knows. According to the faulty hair follicles theory, blocking DHT 100% should work to restore lost hair. It doesn't, though. And it might not even matter that we don't know why.
Geneticists like Angela Christiano are taking a different approach and trying to switch HF from resting phase to growth phase using growth factors and even gene transcription. She's identified OSM, a protein in HF that when blocked, turns the switch on for hair growth. The most cost effective cure could eventually come to us as a small molecule drug in a tube or bottle that we slather on our heads like Rogaine except with far better results.
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It absolutely is quantifiable, so if people are claiming DHT sensitivity increases with age there would be literature to back the claim. The theory of androgens is pretty solid they cause miniaturisation and we know that because blocking them halts the progression.
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But this isnt completely true. Blocking just 70% of DHT with finasteride sometimes reverses hairloss in men.
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Indeed, there are many more connecting factors that we don't understand and and need more research on. Some of these factors are weak or lost in people that lose hair as they age, that is, get past puberty. For example, as stated in this article:
"...Wnt-CM treatment restored and increased DP cell expression of genes downregulated by dihydrotestosterone treatment,.."
(https://www.ncbi.nlm.nih.gov/pubmed/24961246/)
Also, there has been research showing the effects of monoclonal antibodies on hair related gene expression. In this case, I feel future treatment involving stem cells for generation of DPc or supporting tissue as in Tsuji's approach, must address this issue to be successful.
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525575/)
Um well also removing DHT clearly works so results and empirical evidence are also a pretty big part of this. If it didnt have results would anyone really be using it? Like a lot in medicine though no one knows anything, and this is the current best stab at the problem so far that gets results. Not much else to say, but clearly its not just DHT.
Halts but doesn't cure baldness. Even castration won't cause full regrowth. The faulty hair follicles theory is lacking.
Scientists are now able to regrow a much more specialized type of hair cell in animals which normally does not regenerate. Progress in hair biology is a few years behind the eightball by comparison. https://www.medicalnewstoday.com/articles/323925.php
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Not necessarily true. It depends which areas follicle express these genes more.
And why does one twin bald at a faster rate than the other? It suggests epigenetic factors are in play as well.
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It's not faulty at all, the theory simply describes what is observed and without question androgens play a major role in the pathogenesis of androgenetic alopecia, sure we don't have a complete model but researchers aren't claiming they do.