Several research studies have investigated the adverse psychological effects of finasteride (
Altomare & Capella, 2002;
Ganzer, Jacobs, & Iqbal, 2014;
Irwig, 2012;
Melcangi et al., 2013;
Rahimi-Ardabili, Pourandarjani, Habibollahi, & Mualeki, 2006;
Traish, Hassani, Guay, Zitzmann, & Hansen, 2011). In 2002, researchers investigating depression as an adverse effect of finasteride, researchers reported that men (
n = 17) who had taken 1 mg per day of finasteride for Androgenetic Alopecia developed moderate to severe depression during treatment and stated that further studies were needed (
Altomare & Capella, 2002). In 2012, Irwig compared rates of depressive symptoms and suicidal thoughts in two groups, men who had taken finasteride and those who had not. Using the Beck Depression Inventory–II (BDI-II),
Irwig (2012) reported that rates of depressive symptoms (BDI-II score ≥ 14) were significantly higher among former finasteride users (75%; 46/61) as compared with the control group (10%; 3/29;
p < .001). The author concluded that patients taking this medication may experience depressive symptoms and suicidal thoughts, and clinicians should advise patients of potential of the risk of adverse side effects.