Hairloss Treatment Pipeline With Pictures

[DanielDüsentrieb]

Since the hairlosstalk pipeline was not updated in years I thought I start with an update. I concentrated on the treatments I am informed of. There are some treatments I haven’t gathered Information so far. So, feel free to add information on the treatments and also if you have additional information on a treatment I already covered. And please correct me if I made a mistake in this post.

Tsuji

Most superior cloning approach.

Clinical application in human at March 2019 (expected) quoted from an email @Noisette received from Tsuji stuff.

Market launch can happen after this trial.



Hairclone

Claire Higgins an advisor from Hairclone is also speaking on the world hair congress in Barcelona in 262 days.

https://www.barcelonahair2019.org/speakers

The steps from hair donation to cell cryopreservation are already developed so banking now puts these patients “first in line” for transplantation of their hair cells. Moreover, the HairClone concept will not stop the underlying thinning process so will need to be repeated every 2-3 years in order to maintain hair density as the patient’s own hair thins. The banking activities could start within a year and will create a patient pool and short-term revenue to the company which will help support the clinical and product development and bring it closer to clinical reality.

http://hairclone.me/follicle-banking/

Many users wanted something to get first in line when hair cloning is available. Here is the chance but if the company stops their research due to lack of funding you lost money and some follicles.

They are trying to gather some money here:

https://capitalcell.co.uk/campaign/hairclone/

Is someone here with financial background? Would you invest?

Their Progress:

There is over 40 years of basic research already to support this concept and the HairClone team have extensive experience in this area. Although more scientific and clinical research is still needed before this concept can be fully developed, we believe that this could be a reality in 2-3 years as many of the steps needed are already known such as:

· Method to remove the follicular units

· Method to cryopreserve hair follicles

· Method to cryobank cells for many years

· Method to micro-dissect out the required cells from the hair follicle

· Method to micro-inject follicle cells back into the scalp

· Monitoring systems to measure hair shaft thickness and hair density

The main questions that research needs to determine are:

· The best markers to use to measure hair follicle inductivity

· The optimum system to expand cells in culture in order to maintain inductivity

· The mechanisms by which re-implanted cells rejuvenate and regenerate hair follicles

http://hairclone.me/hair-cloning/

Tissuse

They are working on smart hair transplant what basically is hair cloning.

They have no official timeline as far as I know. I guess they are still in preclinical phase?


04. September 2018
Kyoto, Japan

The theme for the 2018 TERMIS World Congress is “Integration of Industry, Government, and Academia for Regenerative Medicine,” reflecting the importance of strong cooperation of Industry-Government-Academia to realize tissue engineering and regenerative medicine. (Riken is also presenting but, on another topic.)


https://www.tissuse.com/en/events/


I believe their only tissue engineering is related to hair this should be a good sign.


Further Infromation can be asked here:

E-Mail: info@tissuse.com



The Sanford Burnham Prebys Medical Discovery Institute

Seems like they are now focused on cancer treatment.

https://www.sbpdiscovery.org/team/alexey-terskikh-phd

HLC2020: Do you have a strategy to propel this technology to be @ market before or during 2020?

Dr. Terskikh: As I pointed out earlier – all depends on funding. In principle, we might be able to deliver a product by 2020 given sufficient funding.


This is from an interview from FEB 2017.

https://www.hairlosscure2020.com/category/alexey-terskikh/

Email terskikh@SBPdiscovery.org

Maybe here we can get some information on if they are still on track or if they abandoned the hair loss research. (They were or still are working on Hair cloning)




Follica
@Noisette has gathered the most interesting infos allready. Phase 3 trial should start soon.
https://www.hairlosstalk.com/intera...h-2017-annual-report-2018-04-16.113504/page-8


Rch-01

Shiseido data is expected this year. When the market launch starts nobody knows. But it the data are positive the market launch probably starts soon. (And according to Lee Buckler not just for Japanese)

Sidefact:

Manabu Ohyama who is working for Shiseido (at least there are some rumors he is working for Shiseido. I did not find something official) is speaking on the world hair congress in Barcelona in 262 days.

https://www.barcelonahair2019.org/speakers

https://www.hairlosstalk.com/news/new-research/replicel-rch01-follicles-revitalizing-hair-growth/

Histogen


A late-stage or Phase 3 trial for men has begun in Mexico, Naughton said. Anticipating success, the company is looking toward commercialization


http://www.folliclethought.com/histogen-begins-late-stage-trial-in-mexico/

http://www.histogeninc.com/technology/#development-pipeline

Two proof-of-concept clinical trials of an earlier prototype of CCM were completed outside the US, revealing promising efficacy results. In one trial, 84.6% of patients receiving just one treatment showed a significant increase in terminal hair count and hair thickness at 12 weeks. Improvement of hair growth parameters was still evident after one year.

In the second clinical trial, in which patients received two treatments 6 weeks apart, the increase in total hair count was 46.5% above that seen after a single treatment. Significant improvements were observed in total hair count, terminal hairs and hair thickness at 12 weeks. At one year, hair growth parameters remain substantially above baseline.

The two completed clinical trials have also revealed efficacy in traditionally difficult-to-treat hair loss populations. Subjects receiving treatment in the temporal recession, which is known to be more difficult to treat than other areas of hair loss, saw marked improvement in terminal hair count, with a mean increase of 22.6% at 12 weeks and 25.2% at the 24 week time point. In both trials, men over 40, normally less responsive to non-surgical treatments, responded well to treatment, including a mean increase of 39% in terminal hairs and 19.4% in total hair count in this age group in the current trial.

http://www.histogeninc.com/applications/hair-stimulating-complex/


pictures of histogen

San Diego Union Tribune – Histogen

Oct 2012

https://www.hairlosstalk.com/intera...owth-stats-and-all-that-fancy-nonsense.64213/

https://www.hairlosstalk.com/news/new-research/histogen-hair-stimulating-complex-china/

2016

https://www.hairlosstalk.com/interact/threads/histogen-news-may-5th-2016.98788/page-2

https://www.google.de/search?q=histogen+before+after&rlz=1C1AVNE_enDE709DE709&tbm=isch&source=iu&ictx=1&fir=-ZmeMkf0w3XiKM%3A%2CS3NrhISy9KxR6M%2C_&usg=AFrqEzeGf4nMhL9t-CkpiRbVUAJTGdcmNA&sa=X&ved=2ahUKEwjT46W8mdLcAhUE6KQKHVjxBtwQ9QEwAnoECAYQCA#imgrc=WSCvVg5FW1CiYM:


PolarityTE

https://www.polarityte.com/products

This picture gives hope they are working on a hair product. But there is nothing official.

They are very advanced in helping patients to regenerate burned and damaged fully functional skin.


Brotzu

Fidia gave no update since January 2017 when they claimed brotzu is ready for marketing by 2018

https://www.fidiapharma.com/en/news/prof-brotzu-s-hair-loss-remedy,3,115

This picture is of someone who used the self-made version of the brotzu lotion

This picture is of someone who used the self-made version of the brotzu lotion.

These are the official pictures from the brotzu lotion on the sitri conference.









Kerastem

Kerastem is undergoing a phase 2 clinical trial in the US

http://kerastem.com/product-pipeline/#pipeline-4

But you can already get the treatment in the UK. I guess this is due to less strict regulatory?

https://www.belvedereclinic.co.uk/stem-cell-hair-restoration/

(Has anyone tried this or knows someone who got the treatment?)

This is from a study regarding adipose stem cells injected into the scalp. (Not the exact same thing Kerastem is developing!!!)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379938/

Here some pictures from a kerastem study.

Can you guess which side was treated with placebo??

I would say these pictures aren’t great…But the last is giving some hope. And at least they did a good job with lightning and angel.

Full study here:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506773/



Samumed

Sponsor of the next world hair congress in Barcelona

https://www.samumed.com/pipeline/default.aspx

Increased follicle counts and hair bulb Ki-67 signals suggested treatment with SM04554 may have promoted follicular neogenesis and therefore may be a potential treatment for Androgenetic Alopecia. (results from phase 2 trial)

https://www.samumed.com/medium/imag...s-phase-2-biopsy-study-for-a-pot_63/view.aspx




Follicum

During the period from late 2016 to early 2017 the first clinical trial was carried out on healthy humans at the Charité Hospital of Berlin. The main objective of the trials was to confirm the safety of the drug, FOL-005, but also to measure effect. The trial showed, first of all, that the treatment was safe, but also a considerable increase in hair growth. 76% of the trial persons responded with increased growth. At this specific dose, the hair growth was + 8% compared to before treatment. The increase is statistically ensured (p=0,0038, not adjusted for multiplicity).

http://follicum.com/pipeline/

They have no official timeline of their future development


Here are the treatments I think could be interesting but I haven't covered so far.

Aclaris



Breezula cassiopa



Polichem



Setipiprant



Bimatoprost



Rivertown therapeutics



PTD-DBM

Here is a good summarie of the PTD-DBM peptide.

I've just read through this study, and for a layman, I'm impressed with the lucidity, logic and efficiency of this study.

My understanding is this first thing about this study is it's not just another "wnt pathway induces hair growth" study. Everybody and their mother at this point knows that disruption of the wnt pathway in dermal papilla cells (DPC)results in imparied hair growth, but they've identified a protein (CXXC5) that interacts with one of the specific elements (Dvl) of the wnt pathway to disrupt it. So they know precisely what is disrupting it and where precisely it is being disrupted.

Then they've shown that CXXC5 is expressed highly in DP cells taken from human scalps with Androgenetic Alopecia. Then they've show that by disrupting CXXC5's ability to interact with Dvl by using a peptide (PTD-BDM) that "get's there before it", kind of how Finasteride does with 5ar, that wnt signaling resumes and the cell resumes its normal functioning, so normal hair growth.

Then they've shown that combining PTD-BDM and a wnt pathway activator (like VPA) makes the effect even more powerful. This is good stuff.

Then they've shown that combining PTD-BDM and a wnt pathway activator and wounding can induce follicle neogenesis.

They're actually dropping new science here. To my understanding what were looking at could be Androgenetic Alopecia's achilles heel.

17. August 2018 Kang-Yell Choi will present the following title at the Asia-PacificDermMeet

Title: Hair re-growth and Wound-Induced Hair Neogenesis by targeting CXXC5, a negative feedback regulator of the Wnt/Beta-Catenin

Kang-Yell Choi, Yonsei University, Republic of Korea

https://dermatology.dermatologymeeting.com/scientific-program

 

[nohairnolife]

All of these companies want to treat us right up our pipelines

Jacob25 got better results than half these bozos and he didn't need 20 years and 3 phases

 

[Vinc2097]

All of these companies want to treat us right up our pipelines

Jacob25 got better results than half these bozos and he didn't need 20 years and 3 phases

what's or who's jacob25

 

[Pephair]

Thank you for putting it all together for us!

 

[nohairnolife]

what's or who's jacob25

A dude in the Success Stories subforum who regrew like 2 Norwoods

 

[alibaba92]

A dude in the Success Stories subforum who regrew like 2 Norwoods

what did he use ?

 

[TommyJones]

great read.

not a single remotely decent or convincing photo, though. gets me every time. if we are to judge the value of their research (mostly histogen) by pics, they are more likely to end up in court than on the market.

 

[DAVAT]

Thanks for the update, some people seem convinced that PDD-DBM is one that may make major breakthroughs

 

[DAVAT]

what did he use ?

https://www.hairlosstalk.com/intera...rew-hair-back-look-at-my-change.115473/page-4

 

[DanielDüsentrieb]

Thanks for the update, some people seem convinced that PDD-DBM is one that may make major breakthroughs

That is most likely +10 years away for human application. I think our best shot in the current pipeline is replicel for maintenance and the 4 cloning projects for "regrow". With the automated Hair implantation the cost for the haircloning procedures could decrease.#

https://www.hairlosstalk.com/interact/threads/latest-artas-now-harvests-and-implants.116062/

At least for crown repair if you prefere a human skilled dr for your hairline.

 

[hanginginthewire]

It’s amazing to realize I once looked at such a list with a real sense of hope and excitement. With the exception of Tsuji, it’s just a collection of Hail Marys and ragamuffins. We are so screwed.

 

[nohairnolife]

I understand the truth is painful guys but no need to get buttmad

That is most likely +10 years away for human application.

It's a f*****g peptide. Lab Intern Johnny Baldy could put it together it's just some amino acids

 

[TommyJones]

I understand the truth is painful guys but no need to get buttmad



It's a f*****g peptide. Lab Intern Johnny Baldy could put it together it's just some amino acids

i agree. if its proven to work, you ll be able to get it in no time. the interest is too high.

all those decade long attempts are only so long because they dont f*****g do anything. and the announcements are made in advance, before even developing a product

 

[DanielDüsentrieb]

I understand the truth is painful guys but no need to get buttmad



It's a f*****g peptide. Lab Intern Johnny Baldy could put it together it's just some amino acids

Taking the next step, the team is now conducting laboratory animal tests to discern whether PTD-DBM possesses toxic characteristics, it said.
http://www.koreaherald.com/view.php?ud=20171121000807
If it is just amino acids and totlaly save why they need that step?

 

[nohairnolife]

Taking the next step, the team is now conducting laboratory animal tests to discern whether PTD-DBM possesses toxic characteristics, it said.
http://www.koreaherald.com/view.php?ud=20171121000807
If it is just amino acids and totlaly save why they need that step?

Because it can still be unsafe for people. Amino acids are simple that doesn't mean they're always benign

Choi himself said the tests are basically a formality though; for what's known about the compound's components, there shouldn't be any threat to people. Anyway, throw me in a vat of fuckin toxic waste if it works. I don't care about the toxicity when over half a decade of my life has gone in the trash because of this shitty disease

 

[DanielDüsentrieb]

Choi himself said the tests are basically a formality though

Can you link a source

 

[nohairnolife]

Can you link a source

It was in the original announcement where he said he didn't expect adverse side effects or whatever the f***

 

[DanielDüsentrieb]

Based on this finding, the researchers have developed a biochemical substance, PTD-DBM, that prevents CXXC5 from binding with the Dishevelled protein. When the substance was applied on the bare skin of laboratory mice for 28 days, they saw new hair follicle growth.

Professor Choi Kang-yeol said, “We have found a protein that controls the hair growth and developed a new substance that promotes hair regeneration by controlling the function of the protein. We expect that the newly developed substance will contribute to the development of a drug that not only treats hair loss but also regenerate damaged skin tissues.”

It was in the original announcement where he said he didn't expect adverse side effects or whatever the f***

I did not found yor quote. And i could not find anything about the toxicology study results. The news were from end nov 2017. And i couldn t find something about human trials and because it s going to be a drug it needs to go through approval states so i dont think you can expect this to become reality in under 5 years

 

[Cue Bald]

oh dear, looking at these pictures a quote from another learned member comes to mind

"May God Bless Our Scalps!" - as we are going to need it !

 

[dermrafok]

Can you link a source

Nothing. Pathetic.