We thought that parenteral was far safer and it is but she pushed almost 7 years straight of pregnancy levels and who knows if injections contributed to it but I use the patch which I deem the safest and best E2 med.
I agree about EE and CEE's but we don't have to use them forever, just during initial transition and only if we feel that they are better for hair or among MtF's breast growth, which is a constant preoccupation. @bridgeburn started on ethinyl estradiol if I recall correctly but then switched to 2mg bio-identical tabs and he was at 6 mg SL plus a significant dosing of an AA so those are probably levels higher than 300 pg/ml.
"Overall exposure to HRT in the past 90 days was associated with a 43% increased VTE risk"
Most recent study I could find. Looks like it's not how long you are on it for, and after you have been off for 90 days risk decreases significantly. It's just recent use that really increases risk.
Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases
Objective To assess the association between risk of venous thromboembolism and use of different types of hormone replacement therapy. Design Two nested case-control studies. Setting UK general practices contributing to the QResearch or Clinical Practice Research Datalink (CPRD) databases, and...
I believe there was also some chatter going around about the COVID vaccine blood clots affecting primarily females on birth control also.