In my opinion, Alfatradiol seems to be underrated. Maybe the 0.025% it's not very much or maybe is enough for others, but with higher doses, someone might achieve better results. Forget it to act like a DHT blocker when someone is already on Finasteride or Dutasteride because the latters will do the job, outpeforming Alfatradiol in the 5AR blockade. The interesting part of Alfatradiol is the increment in Aromatase Activity and the capability to block 17β-HSD. We know that Aromatase is so important for Hair Follicles and I believe that's the most interesting part of Alfatradiol. Furthermore, as much as it can block the 17β-HSD it's a plus as well, because is blocking the conversion of T to Androstenedione, thus promoting the conversion to the Estrogens, Estrone and Estradiol. Only problem is the ERα receptor binding affinity.
www.ncbi.nlm.nih.gov
It helped me a lot, just caused extreme depression too.
Okay then. Show, Almas two people under 20 benefiting from finasteride
Are you saying that orchiectomy, HRT and Bicalutamide did not help you, but Finasteride did? lol
The likelihood of curing stage 4 cancer is higher than curing early baldness with Finasteride. Finasteride should be considered only as an adjuvant, but by itself it does not work in young people.Okay then. Show, Almas two people under 20 benefiting from finasteride
I'd be careful with being in the upper E2 ranges for a long period of time, with the risk of blood clots and all. There's also the risk of receptor down regulation, meaning you have to keep increasing the dosage for the same effect. I stopped all estrogen for 3 weeks since it was doing little anyway, and restarted once I started feeling weak and old (menopausal symptoms I guess) and have since restarted injections at a quater dose.
I was about 35 when I went on it and I felt nothing and saw nothing growing in but that and min gave me pretty good maintenance. However, not everyone who balds early is facing the same hormonal devastation as others. I have encountered MtF's who began balding at 15 who apparently still lack any success at regrowth. While we have the Norwood scale, that doesn't exactly explain why some end up NW7 and others then bald only slowly going forward.
I do not know how this is explained, but now I will upset everyone who began to go bald before the age of 20: your final point is a bald head. Finasteride will not help you, just jump on Bicalutamide, have breast surgery and switch to HRT. You may notice that everyone who started to go bald at an early age cannot stop the progression with Finasteride or Duta. Also, in one of the Finasteride studies, there was information that the older the person, the higher the chances of success, and there are simply no people under 20 in the studies.
I actually posted an article above related to this. Someone I really admire had been maintaining pregnancy levels of E2 for over six years via injections and she has recently had a serious bout with DVT which certainly gives me pause. I am actually going to test today because my provider is concerned and thinks levels should be between 100 pg/ml and 200 pg/ml which is too low so I have proposed to her to shoot for 300 pg/ml but I haven't heard back yet.
Noah restored hair at 200 pg / ml if I remember correctly
I know that you are not MtF but I predict more and more young guys going on HRT and being fine with being non-binary since in itself, that term doesn't mean a whole lot but they will struggle less than you have and less than I have. In some ways, my dysphoria from HRT has been brutal since I have been on it and it was even more brutal beforehand. It is still the most humiliating thing for most guys in virtually all societies to express solidarity with females, either physically or psychologically. Many of us grow up playing sports and HRT is obviously not compatible with those activities unless one competes as a female and that is probably a mind-f*** for those trans females as well.
He was also your age. I am just feeling around in the dark like anyone else but if I succeed in this, starting essentially at 55 with high dose, I think that it is going to catch the attention of others, especially those who allege that the longer you have been bald, the more screwed your are in terms of restoration and that is probably true. I had 40 years of incessant T bombardment to deal with plus raging out of control dermatitis. I could never go back to that, not to mention the male compulsive mind set. I am compulsive plenty under HRT but it is much more akin to being interested and not being compelled. It's all a huge mind-f*** and it will continue to be for you, Almas, too as you live in an unsympathetic nation.
I can endure a lot, but not baldness. If necessary, I will use HRT. Yes, there is a lot to sacrifice. All I want is f*****g hair. Is there anything in this universe that can help me?
Well. You just started still. I am not saying that we are doctors but I think that we have a huge amount of accumulated knowledge on here and if bica doesn't entirely do the trick, then adding to the stack will be an option. I agree about baldness and perhaps I was socialized differently but I would much prefer to be a female with amazing hair assuming I am decent otherwise than to be six feet tall and weight 225 lbs or something with a big bald Col Kurtz pate. I am petite and that is a huge benefit for many MtF's.
You can hide the fact that you are using hormone therapy. Don't wear makeup, wear men's clothing, act like a man, etc. People will notice the oddities in the facial features, but they will not suspect anything
I have soft features and short stature - I am an ideal candidate for HRT. But not as perfect as Noah - he is prettier than me.
True and I am fine with that but my family still doesn't get it, nor my ex-wife. At least you only have the issue with your hair. For me, the compulsive aspect began right at the same time as beard growth and I got to the point after 40 years where I couldn't hack it anymore. For me, androgyny is what compelled and compels me but only after HRT could I get the compulsive desire for castration or whatever to get my hair back to relent. The androgyny fixation actually started before I noticed that I was going bald and I never understood how the two fit together and they still don't entirely. I am not nor have I ever been deemed "effeminate" not that there is anything wrong with that but I am trying to explain why some people are so surprised that I re-assigned at least legally as female at age 55.