"The affinity of bicalutamide for the AR is approximately 30 to 100 times lower than that of DHT (IC50 ≈ 3.8 nM), the main endogenous ligand of the receptor in the prostate gland.[37][13][1][38] However, sufficiently high relative concentrations of bicalutamide (1,000- to 10,000-fold excess) are able to completely prevent activation of the AR by androgens like DHT and testosterone and subsequent upregulation of the transcription of androgen-responsive genes and associated effects.[39][20][40][41] At steady-state, relative to the normal adult male range for testosterone levels (300–1,000 ng/dL),[42] circulating concentrations of bicalutamide at 50 mg/day are roughly 600 to 2,500 times higher and at 150 mg/day around 1,500 to 8,000 times higher than circulating testosterone levels, while bicalutamide concentrations, relative to the mean testosterone levels present in men who have been surgically castrated (15 ng/dL),[43] are approximately 42,000 times higher than testosterone levels at 50 mg/day."
so 1000 fold extra concentrations are needed to block AR signaling completely.
at 50mg the concentrations are 2500 relative to 300ng/dl of androgens when DHT is unblocked.
300*(2500/1000)=750ng/dl of androgens are blocked by 50mg of Bicalutamide. so 750ng/50mg=Bicalutamide has
potential to block up to 15ng of Androgens by itself at 1mg dosage.
at 50mg the concentrations are 600 relative to 1000ng/dl of androgens when DHT is unblocked.
1000*(600/1000)=600ng/dl of androgens are blocked by 50mg of Bicalutamide. so 600/50mg=Bicalutamide has
potential to block up to 12ng of Androgens by itself at 1mg dosage.
at 150mg the concentrations are 8000 relative to 300ng/dl of androgens when DHT is unblocked.
300*(8000/1000)=2400ng/dl of androgens are blocked by 150mg of bicalutamide so 2400ng/150mg=Bicalutamide has
potential to block up to 16ng of Androgens by itself at 1mg dosage
at 150mg the concentrations are 1500 relative to 1000ng/dl of androgens when DHT is unblocked.
1000*(1500/1000)=1500ng/dl of androgens are blocked by 150mg of bicalutamide so 1500ng/150mg=Bicalutamide has
potential to block up to 10ng of Androgens by itself at 1mg dosage
at 50mg the concentrations are 42000 relative to 15ng/dl of androgens when DHT is unblocked.
15*(42000/1000)=630ng/dl of androgens are blocked by 50mg of bicalutamide so 630ng/50mg=Bicalutamide has
potential to block up to 12.6ng of Androgens by itself at 1mg dosage
Based off of my scientific data,
Bicalutamide when DHT is untouched, can block between 10-16ng/dl of Androgens. I would assume the number to be closer to 16ng/dl if DHT is being blocked and 10ng/dl of Androgens when DHT is not being blocked.
Thats why the guy who used 50mg Bica, 1mg finasteride, 60mg Ralox was unsuccessful (his PSA was 0.2ng/ml) since his Testosterone was 1476ng/dl.
Finasteride reduces DHT by 66% so we will say in this scenario 14ng/dl of T is being blocked per mg of his Bica.
50*14=700ng/dl of T is being blocked. 1476-700 = 776 free nanograms of T not being blocked by Bica.
hope this helped
