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Different lights and different angles, combover !! nooooooo i'm jokiiiiiing ! so good your results ! your are now a god of hair !
Exploring The Hormonal Route. Hair=life.
- Thread starter bridgeburn
- Start date
Different lights and different angles, combover !! nooooooo i'm jokiiiiiing ! so good your results ! your are now a god of hair !
- Reaction score
- 98
Cheers mate. I am excited to just get started. I just want some regrowth. This is the best hrt drug for me because it doesn’t effect androgens like the others. I want to be on this long term so fingers crossed it works for me.
Dutasteride + Bicalutamide + Oral Minoxidil; will that be your regimen?
This is the regimen I've been advocating for a month now. That is the best regimen with minimal sides vis-a-vis benefits.
- DHT blocker - check
- Test and other androgens blocker - check (I know bica doesn't directly block it)
- Growth stimulant - check. Pretty powerful one.
- Reaction score
- 98
Yes. I have a years supply of spironolactone to haha.
At least the spironolactone can be used just incase water retention occurs due to the oral minoxidil. Although, that trio (bicalutamide/dutasteride/minoxidil) will be greatly effective...
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- 178
So youre one of the few who doesn't get side effects (lethargy, etc) from spironolactone?
I agree, when it comes to minimal side effects. For transgender individuals, or those who don't mind the effects of estrogen, then bicalutamide/dutasteride/estradiol will be the best option. It will make bicalutamides job easier, since the amount of T to block is significantly reduced, and there is a synergetic effect between bicalutamide and estradiol. It will also make an orchiectomy in the future possible, since your T won't raise if you stop bicalutamide.
So for somebody like me who will never take any form of estrogen directly, will Cypro 12.5/25mg or metformin (not much evidence but sufficient studies available) or sth like SARM would do - to lower test levels? Just in case I may have to go this route and think of 25mg bicalutamide.
It would work, but you would have to use it along with oral minoxidil since CPA additionally lowers E. Although, you shouldn't use an NSAA with an SAA as @DHTcel explained.
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The only side effects I got on spironolactone was gyno and loss of libido. But my testosterone was nuked on spironolactone.
I brought more because I thought if 200mg nuked my testosterone so much maybe a lower dosage would be better for me. But the I heard about bica and that sounds like a much more suitable treatment for me as I have a girlfriend haha.
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- 178
I'm having a slightly more difficult job getting bica from my Doctor, but do have spironolactone on hand. I'm hoping that with dutas and and small amount of topical estro (0.2-0.3 mg), I might be able to see regrowth with as low as 50 mg of spironolactone? Or is that just a fantasy lol
How was your experience with RU?
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- 1,717
lol i like that your profile pic is of the Vegetable Police
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Is this still the current regimen @bridgeburn and do you split the 25mg cypro into 2 doses of 12.5mg /day or do you just take it all at once.
i know youre on Spironolactone and CPA together.
@DHTcel says taking NSAA's & SAA's together is pointless what do you think ?
I'm on CPA 12.5mg x2 daily 12 hours apart. with 2.25mg oestrogel circulating in my blood consistently. and soon to be on Bicalutamide 50mg x1 daily.
i read a study that said 25mg CPA vs 1mg Finasteride had same effect on lowering DHT with the additional lowering of T, A & DHEAS from CPA. (obviously youre on 5AR inhibitors aswell as CPA) but would it be pointless to take all CPA & Bical with Dutasteride together.
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He asked me to show this thread: https://www.hairlosstalk.com/intera...ess-beneficial-for-treating-hair-loss.123271/
- Reaction score
- 679
[QUOTE = "LEXUS, сообщение: 1809635, участник: 139951"] вы не читаете внимательно. Я принимаю только 16 мг ципротерона. Единственная проблема с ципротероном заключается в том, что он разрушает эстрадиол. [/ QUOTE]
[QUOTE = "LEXUS, post: 1809635, member: 139951"] вы не читаете внимательно. Я написал, что сейчас я принимаю только 16 мг ципротерона. Единственная проблема с ципротероном заключается в том, что он разрушает эстрадиол. [/ QUOTE]
[QUOTE = "LEXUS, post: 1809635, member: 139951"] вы не читаете внимательно. Я написал, что сейчас я принимаю только 16 мг ципротерона. Единственная проблема с ципротероном заключается в том, что он разрушает эстрадиол. [/ QUOTE]
Gels are more convenient, it immediately enters the blood.
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- 1,717
So according to the article i will only need Bicaludamide and estrogen, and that alone will reverse and inhibit DHT with the other androgens from having an effect in my body without needing a 5AR inhibitor?
He said:
“1)1mg bicalutamide blocks 10ng/dl of testosterone if DHT is not being blocked and 16ng/dl if someone is using dutasteride because DHT has a 0.25nM Kd and T has a 0.4nM Kd (Kd=binding affinity) progesterone and progesterone derivatives (SAAs) have a higher affinity than NSAAs and therefore break their bonds and render the NSAAs useless
2)tell him if he uses estrogen then he can get away with 12.5mg bicalutamide because at that dose 125ng/dl would be blocked and oral E2 usually drops T to around 50ng/dl anyways
3)if he doesnt use estrogen he can use 50mg bicalutamide with dutasteride and that in theory would block around 800ng/dl of T and there would be no DHT left
4)tell him i recommend he does 75mg bicalutamide with 0.5mg dutasteride since that should block around 1200ng/dl and bicalutamide should put T levels around there and he has agressive hair loss anyways”