Diclofenac Now Available Over The Counter

[alscarmuzza]

In case you ever wanted to give this a go. https://njbiz.com/fda-approves-gsks-voltaren-arthritis-pain-counter-use-us/

There was a study a while back about combining this with minoxidil for a synergistic effect.

 

[Mr White]

In case you ever wanted to give this a go. https://njbiz.com/fda-approves-gsks-voltaren-arthritis-pain-counter-use-us/

There was a study a while back about combining this with minoxidil for a synergistic effect.

It's a topical gel for the treatment of arthritis, why do you say it also treats male pattern baldness?

 

[badhabiz]

It's a topical gel for the treatment of arthritis, why do you say it also treats male pattern baldness?

https://www.researchgate.net/public...Androgenetic_Alopecia_A_Report_of_Three_Cases
And also
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686323/

My concerns are for long term use

 

[Topher]

https://www.researchgate.net/public...Androgenetic_Alopecia_A_Report_of_Three_Cases
And also
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686323/

My concerns are for long term use

I would think that he would of been applying it on his wrists or another body part if that's the case he did get good gains, also considering how old he is it also looks promising.

 

[FilthyFrancis]

Interesting topic

 

[HairCook]

The 3 cases were on 3% btw.

That being said, it has been OTC in Germany for ages and there used to be even a spray version you could perfectly mix with minoxidil which then got replaced with some roll-on version. Some germans are probably still using it, but never heard/saw any big success.

If you look at the mechanism of action, it inhibits cox as most NSAIDs. Means it lowers also the beneficial pge1, pge2 and pgf2a. However bald scalp mostly expresses pgd2 and low pge2, makes sense that there is overall a beneficial effect. Story changes probably once you want actual regrowth, and are already taking finasteride/dutasteride/ru etc and also start more targeting of that pathway (crth2 inhibitors, pge2, pgf2a analogues...). I guess one could in fact try diclo plus topical pge analgues (you probably at least want pge2 analogue plus castor oil and in addition some potent pgf2a like chloprostenol) to avoid this issue and save some money on seti etc (and avoid the non-responder issue with crth2i therapy). I also would avoid diclo while woundling, as inflammation triggers the growthfactors which makes it even less practical as pgd2 and crth2 inhibit wound induced hf neogenesis.

 

[INT]

Interesting. Good find.

 

[ZenHead]

Any links to a 3% gel? Might try this

 

[Hangin'on Hair]

Is this a different voltaren? I've been buying this stuff off the shelf for years.

 

[paul1988]

Interesting. Will keep an eye on this thread and hopefully see some users reports

 

[otis]

In case you ever wanted to give this a go. https://njbiz.com/fda-approves-gsks-voltaren-arthritis-pain-counter-use-us/

There was a study a while back about combining this with minoxidil for a synergistic effect.

Can you post a link on the study or any other info

 

[HairCook]

Can you post a link on the study or any other info

The study was already posted a trillion times in the past, and you can find it with google/pubmed. The solution also included tea tree oil.

 

[HairCook]

It's worth trying.


I think as long as you don't use it the day of wounding, and wait 24 hours after to let the inflammation response begin then it's probably not an issue.

You probably want to stop 24 before and then wait a few days. Cause PGE2 release is going to be increase which you do not want to affect. Generally skin is going to be tilted towards proliferation, nothing you want to mess with. Diclo can be interesting for maintenance, but I would expect it to negatively affect a regrowth regimen.

Sulfasalazine is more promising in this regard.

 

[Pephair]

I've been using Voltarol 2.5% for a couple of months it's working wonders. I also use cetirizine as a PGD2 blocker.

Personally I think anti-inflammatories / anti-histamines / PGD2 blockers are vital for male pattern baldness prevention.

I think in the end it's the inflammatory and/or auto-immune response that causes the hair loss. From what I remember DHT causes perifollicular inflammation.

These are worth a read if you want to learn more:

https://www.ncbi.nlm.nih.gov/pubmed/10217742

https://www.nicehair.org/exactly-why-how-does-dht-cause-hair-loss/

Got any before/after photos?

 

[lawyeah]

I've been using Voltarol 2.5% for a couple of months it's working wonders. I also use cetirizine as a PGD2 blocker.

Personally I think anti-inflammatories / anti-histamines / PGD2 blockers are vital for male pattern baldness prevention.

I think in the end it's the inflammatory and/or auto-immune response that causes the hair loss. From what I remember DHT causes perifollicular inflammation.

These are worth a read if you want to learn more:

https://www.ncbi.nlm.nih.gov/pubmed/10217742

https://www.nicehair.org/exactly-why-how-does-dht-cause-hair-loss/

how do you use cetirizine ? is it expensive like the other anti stahaminics ( fevi, seti etc... ) ?

 

[itsjustsimon]

I've been using Voltarol 2.5% for a couple of months it's working wonders. I also use cetirizine as a PGD2 blocker.

Personally I think anti-inflammatories / anti-histamines / PGD2 blockers are vital for male pattern baldness prevention.

I think in the end it's the inflammatory and/or auto-immune response that causes the hair loss. From what I remember DHT causes perifollicular inflammation.

These are worth a read if you want to learn more:

https://www.ncbi.nlm.nih.gov/pubmed/10217742

https://www.nicehair.org/exactly-why-how-does-dht-cause-hair-loss/

How is it working wonders?

 

[lawyeah]

thank you for answering ! what do u use as vehicule with cetrizine ?

 

[polishkickbuttowski]

I use 10mg cetirizine per 100ml bottle of mixture. I just grind up one of these:

https://www.amazon.co.uk/Allacan-Ce...1_1?keywords=cetirizine&qid=1582581003&sr=8-1

I stole the idea from here:

https://www.nicehair.org/cetrizine-for-hair-loss-reduce-scalp-pgd2/

The authors evaluated the efficacy of topical cetirizine for treatment of androgenetic alopecia in 85 male and female study participants. Overall, 67 participants applied cetirizine 1% daily on the scalp, and 18 applied vehicle as controls. The treatment group showed increased total density, increased terminal density, and decreased vellus density after 6 months of use. Prostaglandin D2 has been implicated in baldness, and the mechanism of action is thought to relate to the anti-PGD2 effect of cetirizine.​

The study says it has no negative sides.

Must be worth a go? A PGD2 inhibitor that costs about 0.0000003 cents per use and has no sides.

I got dry/ red eyes and sometimes a bloody nose from cetirizine. If i recall it has the effect of drying out your mucous membranes. That being said i think its a good idea for a first line of defense treatment and is pretty safe overall. Theres some cetirizine threads you can dig up on this site if you want more info.

 

[badhabiz]

I got dry/ red eyes and sometimes a bloody nose from cetirizine. If i recall it has the effect of drying out your mucous membranes. That being said i think its a good idea for a first line of defense treatment and is pretty safe overall. Theres some cetirizine threads you can dig up on this site if you want more info.

how long have you been taking it? dosage?

 

[badhabiz]

italian study on 1% topical cetirizine
https://calvizie.net/studio-italiano-cetirizina-efficace-la-calvizie/

english v:


https://www.ncbi.nlm.nih.gov/pubmed/28604133