Dexpanthenol May Be A Novel Treatment For Male Androgenetic Alopecia: Analysis Of Nine Cases

pegasus2

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@pegasus2 I cant find your rely on AKG and AKB topical dosage.

My concern with AKG is that it's highly acidic. My skin started shedding majorly and hair with it when I applied .5%. I had literally lumps of skin coming out when I was massaging.

.3% at the most. You can try .1% and see if that alleviates the issue, or just stick with oral. Up to 12g a day for ten days followed by 2-4g a day.
 

Squeegee 2.0

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Dexpanthenol (B5) is a molecule found in the structure of the coenzyme A. It has anti-inflammatory effects including reducing the release of myeloperoxidase from granulocytes. It also has a strong antioxidative effect that increases the synthesis of glutathione, coenzyme A, and adenosine triphosphate.
https://sci-hub.tw/https://onlinelibrary.wiley.com/doi/abs/10.1111/dth.13381

Acetyl-CoA Synthetase Is a Conserved Regulator of Autophagy and Life Span.
https://www.sciencedirect.com/science/article/pii/S1550413114001260

Interesting that Coenzyme A plays a huge part in Krebs cycle.


There was a popular supplement available back then boosting CoA :

x7GwJQX.jpg


 

dgadgdea

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.3% at the most. You can try .1% and see if that alleviates the issue, or just stick with oral. Up to 12g a day for ten days followed by 2-4g a day.

Does this mean taking 12g of AKG orally a day for ten days then following with 2-4g a day? Where did you come across the dosing info pointing to this? or did you mean applying that much topically?
 

John Difool

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The taste is absolutely awful. I tried juices water coffee it's just makes me want to puke.
 

dgadgdea

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I've been adding ~600mg of the Simplesa AKG supplement to my daily shake. Maybe I'll up the dosage. Then again I also do ~5mg of rapamycin weekly which sounds like it covers a similar pathway. I'll stick with some amount of AKG orally daily due to some of recent studies. Hell maybe I'll reverse some gray hairs like those mice.

this is the supplement I've been taking, has some added flavor and doesn't taste too bad:

https://www.amazon.com/gp/product/B00HBZEUTE/ref=ppx_yo_dt_b_search_asin_title?ie=UTF8&psc=1
 
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