Dexpanthenol May Be A Novel Treatment For Male Androgenetic Alopecia: Analysis Of Nine Cases | Page 2 | HairLossTalk Forums
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Dexpanthenol May Be A Novel Treatment For Male Androgenetic Alopecia: Analysis Of Nine Cases

Discussion in 'Hair Loss and Alopecia Published Studies' started by whatevr, Apr 19, 2020.

  1. 2young2retire

    2young2retire Experienced Member

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    Why did this happen?
     
  2. Squeegee 2.0

    Squeegee 2.0 Established Member My Regimen

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    LOL Monty unplugged the Matrix.
     
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  3. 2young2retire

    2young2retire Experienced Member

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    LooooooooL
    Is he here?
     
  4. Squeegee 2.0

    Squeegee 2.0 Established Member My Regimen

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    I haven't see him yet.. He used to be a member on here. He got an hair transplant and probably carried on with his own life lol
     
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  5. 2young2retire

    2young2retire Experienced Member

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    2young2retire 2014: tries Dhurat protocol, gets more hair.
    2young2retire 2020: becomes a click byte thumbnail
    2young2retire 2020: clicks on thumbnail as it looks promising for regrowth
    LOL LOL LOL
     
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  6. polishkickbuttowski

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    It's been 4 days since I started taking Pantethine and today my skin looks less oily then usual. It's still oily to the touch but the oil seems less viscous than it normally is. I'm adding in l-cysteine soon at 500 mg so I'll see if that has an effect. Obviously no hair differences yet because hair is much less reactive than skin is.
     
  7. Dat5Years

    Dat5Years Established Member My Regimen

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    What’s the recommended dosage?
     
  8. polishkickbuttowski

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    Depends on what form of b5 you take. I'm taking 900 mg of Pantethine because it's a common acne dose but no one here knows how much it would take to replicate the study.
     
  9. Squeegee 2.0

    Squeegee 2.0 Established Member My Regimen

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    I am taking Panthetine 950mg a day with L-cysteine 500mg + panthetonic acid 900mg.
     
  10. Squeegee 2.0

    Squeegee 2.0 Established Member My Regimen

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    #30 Squeegee 2.0, May 3, 2020
    Last edited: May 3, 2020
  11. Squeegee 2.0

    Squeegee 2.0 Established Member My Regimen

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    Acetyl-CoA synthetase is a conserved regulator of autophagy and lifespan.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036695/


    Autophagy is essential for maintaining the growth of a human (mini-)organ: Evidence from scalp hair follicle organ culture
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891029/



    Stimulation of Hair Growth by Small Molecules that Activate Autophagy
    https://www.sciencedirect.com/science/article/pii/S2211124719306990


    Hydroxytyrosol prevents dermal papilla cells inflammation under oxidative stress by inducing autophagy

    https://onlinelibrary.wiley.com/doi/abs/10.1002/jbt.22377



     
  12. Squeegee 2.0

    Squeegee 2.0 Established Member My Regimen

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    Derek from More plates more dates is a cool dude too!
     
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  13. Balding curse

    Balding curse Established Member My Regimen

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    Do you really see any improvement at least the oily scalp?
     
  14. Squeegee 2.0

    Squeegee 2.0 Established Member My Regimen

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    Never had an oily scalp.. I can't tell.
     
  15. Alex Contee

    Alex Contee Established Member My Regimen

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    Any updates?
     
  16. Dimitri001

    Dimitri001 Established Member My Regimen

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    From one of Squeegee's studies

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891029/

    "Taken together, our data support a scenario in which intrafollicular autophagy is eminently targetable for the therapeutic modulation of human hair growth. In line with this concept, another agent that positively regulates autophagy, caffeine [49,50], is sold as a hair growth–promoting cosmeceutical and has been shown to also prolong anagen and stimulate the proliferation of hair MK [51]. Autophagy inducers, which are the focus of intense ongoing research efforts [5255], are therefore promising agents for the treatment of hair growth disorders and drug-induced hair loss phenomena characterized by premature catagen induction [56]."

    So, I guess the good news is that this autophagy thing may be used to treat hair loss and it is being intensely studied, but are there any autophagy inducers (besides caffeine) that we could use now?
     
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  17. dgadgdea

    dgadgdea New Member My Regimen

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    Rapamycin has been getting press for inducing authophagy. The anti-aging folks are all geeked about. You can read about it around those forums. Have also heard that dude Peter Attia talking about it on some podcasts.

    This mouse study squeegee posted shows results from applying rapamycin topically. I've though about trying to get some rapamycin powder and mixing in a topical once a week (seems like consensus is you want to apply a single dose ~weekly of rapamycin). I'm currently trying to figure out the world of ordering molecules from China.... alternatively you can get a prescription for pills of it, it was originally approved as a organ transplant drug

    https://www.sciencedirect.com/science/article/pii/S2211124719306990
     
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  18. Capone

    Capone Senior Member

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    Rapamycin, a drug that suppress the immune system.. hmmm given the current state of affairs, I’ll pass.
     
  19. John Difool

    John Difool Experienced Member My Regimen

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    I think you are reading it wrong on Rapamycin.
     

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