i understand what you mean but i have 2 objections:first one...androcur flutamide and anti androgens of that class especially androcur have created not to be gentle or easily bypassed by androgen receptors..androcur for example what it does is that it supress the production of t before it converts to dht...plus it was built for long term commitment for cancer and hrt..think about it....you cant easily mess with that strong medicine...you cant become tolerant on these drugs especially in doses of topical administration which are less than 1mg..
If i developed some kind of tolerance just from topical use and in such a short period (8 months) then anty or transgender people should change their regimen weekly in order to not get used to it.
secondly dht blockers like avodart or fina are not antiandrogens...they just block dht from getting to the ARs...this is why the balding case isnt closed yet...DHT is not THE proble DHT is just one part of the problems when it comes to hormones..DHT the most powerfiul substance BUT is not the only one that contribute in baldness.t binds to androgen receptors too might be not strong as dht but is present...
Now what im going to do is to take orally diane 35 twice a week....should be enough for maintaince..now if your theory is true if i developed some kind of immunity to these drugs they shoyld do nothing...but i dont see that happening
i ll give it a break for a month depending on the results and the i ll see fluta lotion...hate receding temples man...
I read all of Anty's thread, he got amazing, incredible regrowth but later his scalp got super dry and he lost much again, I can't say it's because he developed resistance or increased sensitivity from decreasing androgens because it's possible his scalp was just too dry and experienced a shock loss because inhibiting adrogens decreased sebum and too much topical 16% minoxidil, he then used some oils on his scalp, switched to oral minoxidil and started a even stronger adrogen suppression and was regrowing again! I'm still waiting for an update and hoping he can restore his former ridiculously low hairline again.
Of course, building tolerance is something that can only be pushed to a certain extant, nobody is ever to be able to drink close to their bodyweight in alcohol or run as fast as a car no matter how much they train. I don't mean just being tolerant to the drugs, which may be blocking androgens just as great and strong as they had before but the scalp gets more sensitive to adrogens from the lack of exposure to them. At least this is the theory. And for transgenders, they have more estrogen than testosterone and continuously keep it high. I fear that while blocking/reducing adrogens combined with estrogen is going in the right direction, anything less than a full trans regime could potentially lead to a loss of gains after reaching a peak. Maybe it takes years of continued high amounts of estrogen in the scalp to undo the damage of years of DHT. I do hope sincerely I'm wrong and that your topical just needs to have more absorption. Your right, Cypro isn't the same as finasteride or dutasteride. DHT is a powerful b**ch and it's not the only thing that can be bad for hair but yes, androgens are the problem of Adrogenetic Alopecia. If you had your testicles cut off before puberty, you would not suffer Male Pattern Baldness! So, those other parts of the problem are/were caused by Male hormones. Otherwise, it would be telogen effluvium.
I also think about this, Androgens are necessary to develope facial hair, but old men who have decreasing testosterone levels, don't lose the ability grow facial hair. The test/DHT may not directly make it grow but activate genes to allow it to grow. their beards don't reflect their hormonal profile right now, but that they did have higher androgens than estrogens for years in the past. Anty still has facial hair but he did say it's growth slowed down, perhaps estrogen is part of the reason. I see test/DHT to being opposite of estrogen or like yin and yang. And perhaps E is pretty neccesary to have a chance of maintaining dramatic temple regrowth. Especially, if it's been slick bald and ravashed by androgens for years.
Anyway, There must be some truth to my theory.. Resistance/ tolerance and sensitivity happens to a
certain limit in almost every other way in life.
Here's the evidence..
-drink coffee or energy drinks every day, it can give a short term boost of energy, but if you drink alot frequently, you develope a dependency to it and feel drained of energy or headaches when you don't drink it..
-Drug addicts going through withdraws.
-Steroid users who take them to increase androgen activity, do indeed succeed at first but if they take them regularly the body lessens its own production of testerone because the body starts expecting it to come externally. and if they stop taking steriods then they get lower testerone than before they started, I heard that this is why some users/ bodybuilders cycle it.
-If someone who doesn't exercise regularly starts doing strength training, studies show a drop in blood levels of testosterone(probably from it being used on the muscle cells) at first but if they exercise regularly enough, they get higher levels of baseline testosterone at rest than before they started working out.
-The Immune system, (a person who gets sick often may later get sick less often, compared to someone who didn't ever get sick often.)
-Say someone masturbates everyday, it will feel good but eventually his orgasms will feel better if he abstained for a few days before jacking it.
On that topic, this is completely anecdotal and i don't know how true but from what I've read about Nofap (abstaining from p**rn, masturbation and orgasm) people report hairgrowth even for a few months, but then often lose ground again. sensitivity to androgens?
-This may be a shitty analogy and not exactly the same thing but I think its similar enough to understand my point: Lets say someone wants to avoid sun damage to the skin and decides to stay inside all the time or almost all the time for the rest of their life. This is how I kinda view the transgender thing and not needing frequent switching of regimes. If they really did that they're entire lives, getting very low amounts of sun then they would be successful. I doubt getting a little indirect sunlight through the windows would make much difference or cause their skin to become any darker. BUT if something happens and they can't maintain that lifestyle and need to be exposed to alot more sunlight to be able to survive, then they will get burned by the sun, and be more easily damaged/ and weaker to the sun compared to someone who gets a moderate amount but not too much at one time or too frequently but gradual enough to get a little tan will have the better skin health in the end. Cause it's pretty damn hard to avoid forever.
the list could go on and on.. but I've made my point and probably annoyed you with this lengthy reply and I'm sorry if I have. Actually, I have quite a bit more to say and will post that later.
