Many of you have heard of this drug before. Famous hair loss researcher Angela Christiano has said that it cured hair loss, but caused skin cancer. The drug in question is a variation of SAG (smoothened agonist). It seems much information on this project has been lost over time. I hope we can piece it together in this thread. People lost interest in it due to the risk of cancer, but if there is ever going to be a pharmacological cure I believe it's going to come from finding a way to safely manipulate this pathway. The role of the sonic hedgehog (shh) pathway in hair follicle cycling and morphogenesis was revealed in the late 90s. Then in 2005 Curis published this paper that set the hair loss world abuzz: https://www.sciencedirect.com/science/article/pii/S0022202X15324830 Shortly after publishing that paper Curis partnered with Proctor & Gamble to develop an shh agonist for treating male pattern baldness. They successfully cleared the first of two preclinical milestones with P&G before the partnership was terminated because, "the Hedgehog agonist compounds under development pursuant to the collaboration did not demonstrate an acceptable safety profile". Curis announced that they would seek out another partner for developing the drug, but they either abandoned that idea or were unsuccessful in finding a new partner. https://www.businesswire.com/news/h...hes-Preclinical-Milestone-Hair-Growth-Program Now this study has recently come out showing that tumors regress considerably with one week treatment of shh inhibitor vismodegib while new hair follicles remain intact: https://elifesciences.org/articles/46756 What if the shh pathway was activated just long enough for HF morphogenesis to begin, and then vismodegib was applied for a week. Would that be early enough to prevent any tumors from forming in the first place? I found some interesting posts from a member on this site with the handle "hedgehog_info" who seems to have been connected with Curis. He joined the forum when the partnership with P&G was announced, and then left when the partnership was terminated. His final post: Here are some other interesting posts that I found: This drug was apparently tried by four members of one of the private forums more than five years ago. Reportedly they all regrew hair, but I don't know how much. I wonder if anyone here has seen the pictures, or can get in touch with these people? It's been over 5 years now. It would be nice to know if any of them ever developed any tumors. Maybe they are all dead now? As far as I know nobody else has ever tried this drug for hair loss, and for good reason.