Cb 03-01 Aka Breezula Update 28.02.2018 | HairLossTalk Forums

Cb 03-01 Aka Breezula Update 28.02.2018

Discussion in 'New Research, Studies, and Technologies' started by kuba197, Feb 28, 2018.

  1. kuba197

    kuba197 Established Member My Regimen

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    Some update guys. Breezzula for hair. Winlevi for acne (same compound)

    'Operational Highlights

    • Enrollment was completed on the two phase III pivotal trials for Winlevi in acne. Top line results are expected in H1 2018
    • Enrollment was completed in the phase II dose ranging trial for Breezula in alopecia. A planned 6 month interim analysis will be conducted and top line results will be available June/July'

    'Key strategic events

    • Winlevi®: By the end of 2017, the enrollment for the entire Phase 3 Program for Winlevi was nearly complete. The two Phase 3 pivotal trials had enrolled a total of 1439 subjects in trials in 112 sites in the US and Europe. The long-term open label safety trial had enrolled approximately 604 patients and the pediatric trial is ongoing. The top line phase 3 data will be announced H1 2018.
    • Breezula®: The Breezula androgenic alopecia Dose Ranging Study is being conducted in 6 centers in Germany. The first subject was enrolled in June 2017 and the study closed at the beginning of December with 404 subjects enrolled in this five-arm trial. An interim analysis will be performed after 6 months to get an early view of the best dosing regimen. Top line 12 month results can be expected towards the end of 2018 / early 2019.'
    http://www.cassiopea.com/news-and-media/press-releases/yr-2018/ar-18-02-28.aspx

    FYI: E-mail: info@cassiopea.com
    Telephone: +39 0286891124
    But they don't answer. ( I asked if we can use Winlevi for hair)

    I uploaded product pipline.
     

    Attached Files:

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  2. HairCook

    HairCook Established Member My Regimen

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    Always sad to see things taking this long, when ppl with money have been using it already for years successfully by now.
     
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  3. kuba197

    kuba197 Established Member My Regimen

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    At least they go forward.
     
  4. jomasi08

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  5. Iah11

    Iah11 Established Member My Regimen

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    How different will concentrations be for acne and male pattern baldness? If its the same compound in both, could be that some would still derive benefit from Winlevi, rather than wait two years for Breezula. Pure speculation though.
     
  6. Iah11

    Iah11 Established Member My Regimen

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    Had a look and breezula is going to be released most likely at 5%, whereas acne will be 1%. They claim one reason for this is the thickness of scalp, is greater than skin. Im sure dermarolling before application will give an increased absorption anyway.

    Also interestingly, apart from the receptor blocking function, they claim that the compound reduces skin PGD2. They dont mention whether its a direct inhibition or a knockon effect of reduced DHT binding.
     
  7. Rolandconil

    Rolandconil Established Member My Regimen

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    it looks like skinoren gel against acne and seborrhea. The active substance is azelaic acid. many use it as an anti-androgen. I too think to start to smear this shit.
    only there is one problem, for some reason it seems to me that I have a low dht, and hair falls out due to seborrhea. stress + fatty foods . finasteride did not help me
     

    Attached Files:

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  8. Rolandconil

    Rolandconil Established Member My Regimen

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  9. Afro_Vacancy

    Afro_Vacancy Senior Member My Regimen

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  10. worm

    worm Senior Member My Regimen

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    That's fine, it means they'll capture more market share in aggregate, especially if any competitors come into the space.

    That said, Breezula - what are the results from the initial studies??? What kind of regrowth was achieved?
     
  11. kiwipilu

    kiwipilu Experienced Member My Regimen

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    Very optimistic for this. ... but we know how fast this can go either way..
    Anyway at this point, for me maintenance would be like regrowth. Then little hair transplant to make it good . :
     
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  12. Afro_Vacancy

    Afro_Vacancy Senior Member My Regimen

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    Similar to minoxidil in the proof of concept study. I don't remember if that was 12 or 24 weeks .
     
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  13. worm

    worm Senior Member My Regimen

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    but also an anti androgen right? So potentially more potent and long lasting results right? Also, any sides? What's the estimated time to market, and please dont say 5 years.... :)
     
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  14. dermrafok

    dermrafok Established Member My Regimen

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    Yes. 2022. 4 or 5 years. And yes...pathetic and it's a shame...
     
  15. Afro_Vacancy

    Afro_Vacancy Senior Member My Regimen

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    My impression is that the anti-acne prescription will be out sooner, you can just use that.
     
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  16. Timii

    Timii Established Member My Regimen

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    Provided they stop delaying everything
     
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  17. champpy

    champpy Experienced Member

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    Im not very informed on this product. Who has been using this for years already whrn its still in testing phase? Thanks
     
  18. kuba197

    kuba197 Established Member My Regimen

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    Black market. China. @bryan2003 is using this with success. Currently he starts GB.
     
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  19. worm

    worm Senior Member My Regimen

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    Thanks, did he post any pics? Do you have a link to the thread?
     
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  20. kuba197

    kuba197 Established Member My Regimen

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    stopaga.com
     
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