source:
(2013)
https://www.sciencedirect.com/science/article/pii/S0022202X15364265#s0225
490
The efficacy and safety of minoxidil 5% combination with azelaic acid 1/5% and caffeine 1% solution on male pattern hair loss
H Pazoki-Toroudi, 1,4 R Mobasher Moghadam,2 M Ajami,3,4 M Nassiri-Kashani,1 A Ehsani,2 H Tabatabaie,1 S Khani,2 Z Abbasi,1 M Shizarpour,1 A Firooz1 and Y Dowlati1 1 Center for Research and Training in Skin Diseases and Leprosy, Tehran University, Tehran, Islamic Republic of Iran, 2 Razi Dermatology Hospital,Tehran University, Tehran, Islamic Republic of Iran, 3 Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University, Tehran, Islamic Republic of Iran and 4 Nano Vichar Pharmaceutical Ltd, Tehran, Islamic Republic of Iran
Androgenetic alopecia is a common pattern of hair loss.current therapies like topical minoxidil and oral finasteride have shortcomings like delayed responses and limited hair growth.In this study we evaluated the efficacy of a combined topical solution (5% Minoxidil, 1.5% Azelaic acid, and
1% Caffeine) on hair growth in comparison to a 5% Minoxidil solution or a placebo solution. The study design was as a double blinded randomized controlled trial. 71 Iranian men aged 23 years or more, with a diagnosis of androgenetic alopecia were divided into three groups. They were treated with combined solution (n= 40), 5% Minoxidil (n= 20), or placebo (n= 11) for a total period of 32 weeks. The efficacy of the treatment was evaluated every 6 weeks by Wash Test (number of hairs shed), subjective patient self-assessment, and objective dermatologist assessment. At 12th week of treatment, both combined topical and 5% Minoxidil solutions significantly reduced hair shedding in comparison to the placebo group (p<0.05). Also the efficacy of the combined topical solution at 12th week was as good as the efficacy of 5% Minoxidil solution at 32nd week (p<0.05). In both dermatologist objective assessment and patient subjective self-assessment of the combined topical solution group, moderate and marked response rates were significantly higher than two other groups(p<0.001 vs. placebo and p<0.05 vs. Minoxidil 5%). Our study shows that the combined topical solution results in a faster and better clinical result in comparison to 5% Minoxidill solution or Placebo. Also the combined topical solution has the same side effect profile as 5% Minoxidil solution. We recommend using this combined solution as a treatment option in daily clinical practice
