- Reaction score
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Unfortunately a MistakeYou're right. My mistake.
Unfortunately a MistakeYou're right. My mistake.
At least the US has authorized the company to go ahead with phase 2. If the company starts phase 2 in the US that means 2 good things for you.Unfortunately a Mistake
I have Zero Problem to Stay und US For months to get my hair Back.At least the US has authorized the company to go ahead with phase 2. If the company starts phase 2 in the US that means 2 good things for you.
1. If a US phase 2 study proves the treatment works then you might be able to get it early via blackmarket.
2. If a US phase 2 study proves the treatment works it would move to phase 3 in the US and once it completes phase 3 you could fly to America and get the treatment and then go home. Now, if you do it this way, rather than getting it blackmarket, then you would have to stay in America for months until you've used the treatment long enough that the recovery process will continue even after you go home and stop using the treatment.
I don't know if/when US trials will take place. I've only been speculating about stuff like everyone else. That aside, I don't think that US trial managers will allow people from foreign countries to take part in US trials. IMO the people doing the trials would want to be sure that the participants live close to the study site.I have Zero Problem to Stay und US For months to get my hair Back.
do you think that Phase II trials will only be For US residents or will it also be possible For european People of they Stay in the US For the duration of the trial?
Is this plausible? Can random labs manufacture this antibody or is it too technically difficult?At least the US has authorized the company to go ahead with phase 2. If the company starts phase 2 in the US that means 2 good things for you.
1. If a US phase 2 study proves the treatment works then you might be able to get it early via blackmarket.
2. If a US phase 2 study proves the treatment works it would move to phase 3 in the US and once it completes phase 3 you could fly to America and get the treatment and then go home. Now, if you do it this way, rather than getting it blackmarket, then you would have to stay in America for months until you've used the treatment long enough that the recovery process will continue even after you go home and stop using the treatment.
iirc they have contacted labs regarding HMI but were quoted an amount which was not affordable + it had to be stored in -20CIs this plausible? Can random labs manufacture this antibody or is it too technically difficult?
the same conditions than actual Covid vaccine, treatment is similariirc they have contacted labs regarding HMI but were quoted an amount which was not affordable + it had to be stored in -20C
Oh, that's right. So then they CAN produce it, I guess the question then becomes can they produce it at some reasonable price. I mean we've come to terms now with the likelihood that it's gonna cost a lot of money, 10s of 1000s of $, so could the labs produce it at something like that kinda price is the question now.iirc they have contacted labs regarding HMI but were quoted an amount which was not affordable + it had to be stored in -20C
I would think the blackmarket price would be cheaper because a lot of the blackmarket chemicals come from countries where labor is less expensive, such as India and China.Oh, that's right. So then they CAN produce it, I guess the question then becomes can they produce it at some reasonable price. I mean we've come to terms now with the likelihood that it's gonna cost a lot of money, 10s of 1000s of $, so could the labs produce it at something like that kinda price is the question now.
86 pages… Can someone summarize for me; is high prolactin good or bad? What is Bayern trying to achieve with this antibody?
If you wanted to know that all you had to do is look up the definition of antibody.86 pages… Can someone summarize for me; is high prolactin good or bad? What is Bayern trying to achieve with this antibody?
86 pages… Can someone summarize for me; is high prolactin good or bad? What is Bayern trying to achieve with this antibody?
Is this definite? Dr. Rassman said this yesterday:Virtually all humans regrow hair with oral minoxidil. Many don't regrow hair with topical minoxidil because they lack the enzyme in the skin which converts minoxidil into its active form. Taking it orally converts it in the liver where the enzyme is present in all humans, so that's why all of them respond to oral minoxidil even though they don't respond to topical. Apparently all macaques have the sulfotransferase enzyme in their skin.
Response rate is around that for topical, but studies have found a response rate near 100 for oral minoxidilIs this definite? Dr. Rassman said this yesterday:
Do you prefer to prescribe oral or topical minoxidil?
Jun 6, 2022/by William Rassman, M.D./Hair Loss Causes
I have no preference. Only about 40% of men are minoxidil responders and when they do respond, they respond to both the topical and the oral. The topical keeps it local
This is great stuff. But here’s what doesn’t make any sense. Hdac4 apparently inhibits runx2. From my understanding runx2 is needed for hair growth.Acetylation modulates prolactin receptor dimerization
Prolactin receptors: New mechanism may play role in cancer
If women had no prolactin receptors on cells in their mammary glands, they would not produce milk when they were nursing. Prolactin receptors are also found in other organs including the lung and the colon. The only problem is that these receptors are sort of like cellular wiring, and when the...www.sciencedaily.com
HDAC4/9 are present in healthy hair follicles and this study reveals they are strongly associated with Androgenetic Alopecia. It was always assumed that this association was due to them being corepressors of the AR, but they are also corepressors of the PRLR.
I think the balance of HDACs and HATs is skewed in Androgenetic Alopecia creating upregulation of AR and PRLR, which ultimately represses canonical Wnt signaling, causing a progressively shorter anagen phase. From the top SNPs in this study there is the AR of course, then genes that regulate AR and PRLR transactivation, PAX1 and TWIST which are involved in Wnt signaling and upregulated by PRLR. It certainly seems like Androgenetic Alopecia is driven by coactivation of the AR and PRLR. AR activation itself recruits histone acetyltransferases, which upregulate PRLR. Crosstalk between the two then takes place.
ASC-J9 may be an ideal AR antagonist to use with HMI-115, as curcumin inhibits HATs.
HAT inhibitors have shown success in prostate cancer.
"A limited number of HAT inhibitors are in preclinical or clinical trials, with p300/CBP and P/CAF-specific inhibitors showing the most promising effects"
Androgen Receptor Signalling in Prostate Cancer: The Functional Consequences of Acetylation
The androgen receptor (AR) is a ligand activated transcription factor and member of the steroid hormone receptor (SHR) subfamily of nuclear receptors. In the early stages of prostate carcinogenesis, tumour growth is dependent on androgens, and AR directly ...www.ncbi.nlm.nih.gov
Estradiol promotes prolactin transactivation by inducing histone acetylation through ERα, but the predominant estrogen receptor in the scalp is ERβ and it silences ERα. So estradiol does not upregulate prolactin signaling in the hair follicle, despite upregulating it in other tissues.
Epigenetic Mechanisms in the Dopamine D2 Receptor-Dependent Inhibition of the Prolactin Gene
Abstract. Transcription of the prolactin gene is dynamically controlled by positive and negative hormone signals that target the regulatory promoter region. Basacademic.oup.com
HDAC inhibitors also work for prostate cancer, through inhibiting HSP90.
Androgen Receptor Signalling in Prostate Cancer: The Functional Consequences of Acetylation
The androgen receptor (AR) is a ligand activated transcription factor and member of the steroid hormone receptor (SHR) subfamily of nuclear receptors. In the early stages of prostate carcinogenesis, tumour growth is dependent on androgens, and AR directly ...www.ncbi.nlm.nih.gov
Prolactin actually upregulates HSP90
ATM Is Required for the Prolactin-Induced HSP90-Mediated Increase in Cellular Viability and Clonogenic Growth After DNA Damage | Request PDF
Request PDF | ATM Is Required for the Prolactin-Induced HSP90-Mediated Increase in Cellular Viability and Clonogenic Growth After DNA Damage | Prolactin acts as a survival factor for breast cancer cells, but the prolactin signaling pathway and the mechanism is unknown. Previously, we... | Find...www.researchgate.net
It is theorized that in castration resistant prostate cancer AR activation is continued in part by "mechanisms including activation of kinase pathways that can both stabilize AR and enhance its transcriptional activity and upregulations of AR coactivators that increase AR mediated transcription. These sensitize AR to lower levels of ligand."
Targeting the androgen receptor pathway in prostate cancer
When prostate cancers progress following androgen depletion therapy, there are currently few treatment options with only one, docetaxel, that has been shown to prolong life. Recent work has shown that castration resistant prostate cancers (CRPC) continue ...www.ncbi.nlm.nih.gov
Prolactin upregulates all of these pathways that hypersensitize the AR.
Also of importance, HSP90 promotes transcription of Twist1. Twist1 ablation results in perpetual anagen phase in mice.
Inhibition of Heat Shock Protein 90 suppresses TWIST1 Transcription - PubMed
Molecular chaperone heat shock protein 90 (HSP90) is involved in oncogenic signaling pathways including epithelial-mesenchymal transition (EMT), a key process in tumor initiation, progression, metastasis, and chemoresistance. The molecular mechanisms underlying the involvement of HSP90 in EMT...pubmed.ncbi.nlm.nih.gov
You can see from all this that the AR and PRLR are very interconnected. It's not hard to imagine that silencing the PRLR would stop the positive feedback loop between the two receptors and reverse male pattern baldness in a more potent and lasting way than current treatments, which is what was observed in stump-tailed macaques. Returning AR sensitivity to normal and restoring homeostasis could give lasting results that simple DHT inhibition does not.
Ultimate hair loss stack?: HMI-115, ASC-J9, Estriol. Nothing else needed for full reversal?