Bayer Prolactin Receptor Antibody For Male And Female Pattern Hair Loss

R_gesus

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So what is the overall sentiment on this then? I am really thinking about getting a hair transplant now and then to thicken up/maintain with HMI-115 in the future (even if it will be available later than 2025) as I am not going to take finasteride.
You should wait until at least phase 2 is over to make plans that concrete. People can tell you a lot of things now, but only hard data in humans will give you the information you need to make a decision like that.
 

-specter-

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so wait for the publication of phase two data before deciding whether to have a transplant or wait for this therapy to be commercialized?
 

coolio

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Baldness cures generally sink or swim in phase 2.

Phase 1 just proves that a drug won't harm you.

Phase 2 is when they start proving it can grow hair.
 

pegasus2

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The phase 1 in Australia is as good as a phase 2. It's 6 months long. That's long enough to confirm that it works. Should have results first quarter next year
 

LuckyLuke1

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Sorry if I intrude but I still don't quite understand. Have they gotten approval for phase 2 in the usa, will they start it concurrently with phase 1 in australia or will they wait for the latter?
 

pegasus2

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Sorry if I intrude but I still don't quite understand. Have they gotten approval for phase 2 in the usa, will they start it concurrently with phase 1 in australia or will they wait for the latter?
They do have approval to run a phase 2 in the US. No one knows if they will wait or not.
 

pegasus2

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Zon Ama

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Even $60,000 or $80,000 is still a lot of money, especially for young people.

Where do you get those numbers from? Stop being so pessimistic. Not a single cosmetic chirurgical procedure costs that much.
 

JohnDoe5

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This very thread is where I was first informed that prolactin is involved in hair loss. I'm starting to surf the web about prolactin & hair loss and the link I provide below is the first thing I came across about this issue. I always thought hair loss was only about androgens + genetics but according to the article below it would appear that prolactin is involved in hair loss as well. However, the below article seems to indicate that prolactin's involvement in hair loss comes from its effect on testosterone, and testosterone is an androgen. Hence, since prolactin might grow hair via prolactin's effect on androgens, couldn't that mean prolactin *might* cause unwanted androgenic side effects the same as anti-androgens do?

 
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ppma

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Right now HMI 115 is just a monoclonal antibody, with all its drawbacks. However, if it sees the market, it is not going to be in such a form, but more likely as a mRNA serum. mRNA has experienced a boost in development "thanks" to Covid-19, and is viable to produce not only antigenic proteins but also it should be able to produce complex antibodies.

This would be a logical step for commercialization, as reducing costs and increasing the market are two variables that are not related linearly. Meaning, at a cost of 20k$ (as estimated by pegasus2), decreasing it to 5k$ (1/4), the demand would not increase by 300%, but maybe to 3000%. Yet it's all logical speculation and the trials in the US and Australia should prove positive results before thinking about putting it into the market.
 

Hope111

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but would it be a treatment that would have to be repeated every so often? for example 4 years?
 

pegasus2

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Right now HMI 115 is just a monoclonal antibody, with all its drawbacks. However, if it sees the market, it is not going to be in such a form, but more likely as a mRNA serum. mRNA has experienced a boost in development "thanks" to Covid-19, and is viable to produce not only antigenic proteins but also it should be able to produce complex antibodies.

This would be a logical step for commercialization, as reducing costs and increasing the market are two variables that are not related linearly. Meaning, at a cost of 20k$ (as estimated by pegasus2), decreasing it to 5k$ (1/4), the demand would not increase by 300%, but maybe to 3000%. Yet it's all logical speculation and the trials in the US and Australia should prove positive results before thinking about putting it into the market.
This is fantasy. They aren't wasting time trialing an antibody to start over with an mRNA drug. This company doesn't even work with mRNA. They don't have the expertise to develop it. They bought the rights to the antibody to commercialize it. There's zero chance they do what you're suggesting. Another company might do it long down the road. Also, 20k is not my estimate. I would estimate between 20-50k. 20k would be very cheap for a mAb.
 
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coolio

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Simple capitalism says it will be sold as cheaply as possible. A monoclonal-based hair fix is not in any danger of crossing the tipping point where they start to lose money by lowering the price farther.

If it's possible to do it for $20k, then it will come down to $20k within a few years.
 

froggy7

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Simple capitalism says it will be sold as cheaply as possible. A monoclonal-based hair fix is not in any danger of crossing the tipping point where they start to lose money by lowering the price farther.

If it's possible to do it for $20k, then it will come down to $20k within a few years.
the price is a bald man's dream, the reality will be different - beauty is for the rich, only
 

pegasus2

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Simple capitalism says it will be sold as cheaply as possible. A monoclonal-based hair fix is not in any danger of crossing the tipping point where they start to lose money by lowering the price farther.

If it's possible to do it for $20k, then it will come down to $20k within a few years.
It was possible to sell propecia for $1/mo, but it was a couple hundred until generics came out.
 
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