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But in this case hope Medicine has IND Approval For Phase II studies in US. So they should move in this fuc.king Phase II Trial as planned
Bayer Prolactin Receptor Antibody For Male And Female Pattern Hair Loss
- Thread starter Ollie
- Start date
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- 342
The subreddit r/HairlossResearch has introduced Professor Rodney Sinclair as a resident expert (announcement). He is on the team of Sinclair Dermatology which is the outfit recruiting for the HMI trial in Australia. Perhaps we could get some info out of him. Thanks to TrichoSearch on Reddit for the tipoff!
Shouldn't even post that here, he's going to get spammed by trolls and quit reddit.
If the trial renders positive results, just hoping that the next step towards market goes through the mRNA pathway. Creating monoclonal antibodies is a expensive process, but the antibody sequence could be translated into mRNA for its production inside the body.
(https) pubmed.ncbi.nlm.nih.gov/30795778/
(https) pubmed.ncbi.nlm.nih.gov/30795778/
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- 985
So in the mRNA pathway When the product could be commercialized?
Couldn't tell really, but if the monoclonal antibody demonstrates efficacy (phase 3), then the mRNA version should undergo all the testing and trial phases since it would be a different product... Realistically, I guess that we would all be slick bald when a supposed release of an mRNA BAY/HMI-115 reached the market.
My wish concerns only money and logistics only.
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How would an mRNA approach work here? Doesn't mRNA tell cells to produce proteins? Or is an antibody a protein - pardon my ignorance.
Also, I wonder if Bayer's patent would permit someone to go down the mRNA route.
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It is all nonsense we Are discussing about. Phase 1 just started in Australia. We will hear about the results in Fall/winter of 2023 and See whether they start a Phase 2 in US in 2024.
until then we won‘t hear anything of Hope Medicine so there is Nothing to discuss unfortunately until end of 2023. See you Next Year!
until then we won‘t hear anything of Hope Medicine so there is Nothing to discuss unfortunately until end of 2023. See you Next Year!
I hope this is not the case and phase 2 starts this year. this industry is cursed or just sucks. it is impossible to think that ineffective and probably harmful vaccines have passed in a year and that for these things the fda and the financiers make so many problems.
yes of course in 25 years new things have been discovered but always only the hormonal side is targeted.
if this is long delayed, fails or has too dangerous side effects, it will be easier to imagine the end of industrial society rather than the end of baldness.
yes of course in 25 years new things have been discovered but always only the hormonal side is targeted.
if this is long delayed, fails or has too dangerous side effects, it will be easier to imagine the end of industrial society rather than the end of baldness.
The trial is already recruiting. It's only 6 months. What makes you think it will take 18 months to get results?
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The Status of the trial is „Not yet recruiting“.
We could be happy If we hear something und end of 2023. The study completion is in March 2024 so Maybe we will get the results in Summer 2024…
These Are the Dates For the Phase I Trial:
| Estimated Study Start Date : | April 2022 |
| Estimated Primary Completion Date : | July 2023 |
| Estimated Study Completion Date : | March 2024 |
There is No reason to believe we get the results earlier then it is officially announced on clinicaltrials.gov unfortunately
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the Point i made was about getting the product For yourself. Yes, it would be Good to hear about brilliant results of reddit Users who Are in this Trial But i don’t Want to jerk off on their pictures i Want to get this treatment this year and my Full Head of hair Back
Those dates don't mean anything. They're just there because they have to put something, and they'd rather give themselves extra time than not enough. Dr. Sinclair who is conducting the trial has stated that it is already recruiting. Anyone who lives in Victoria should apply www.sinclairdermatology.com.au There is no placebo arm, so you're guaranteed to get the antibody if you get in.
That was never going to happen. Their optimistic target for commercialization was 2024 before they had a 6+ month delay getting a phase 2 trial going
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If they had started Phase II trials in Europe i would have Good chances to get my hair back this Year.
Can you please Tell me Why they don’t have a Placebo? Isnt that Duty to do that?
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You don't need placebo when you're checking only for adverse events, which is what Phase 1 trials do.
So what is the overall sentiment on this then? I am really thinking about getting a hair transplant now and then to thicken up/maintain with HMI-115 in the future (even if it will be available later than 2025) as I am not going to take finasteride.